Rhodiola
This article provides general nutrition information only and is not medical advice.

Overview
Rhodiola is a plant. The root has a long history of use as medicine, especially in Arctic and Northern European regions.
Rhodiola is used as a so-called "adaptogen", to help the body adapt to and resist physical, chemical, and environmental stress, and for many other uses, but there is no good scientific evidence to support these uses.
Some people use the term "arctic root" as the general name for this product; however, arctic root is actually a trademarked name for a specific commercial extract.
Classification
Is a Form of:
Plant
Primary Functions:
Help the body adapt to and resist physical, chemical, and environment stress
Also Known As:
Racine de Rhadiola, Rhodiola rosea, Rhodiole
How Does It Work?
Rhodiola extracts might help protect cells from damage, regulate heartbeat, and have the potential for improving learning and memory.
Uses
- Altitude sickness. Early research shows that taking rhodiola four times per day for 7 days doesn't improve blood oxygen or oxidative stress in people in high-altitude conditions.
- Heart damage caused by certain cancer drugs (anthracycline cardiotoxicity). Early research shows that taking a chemical found in rhodiola called salidroside, starting one week before chemoroutine and continuing throughout chemoroutine, reduces heart damage caused by the chemoroutine drug epirubicin.
- Stress. Early research shows that taking a specific rhodiola extract twice daily for 14 days can improve stress levels and reduce feelings of anger, confusion, and poor mood in college students with stress.
- Athletic performance. There is conflicting evidence on the effectiveness of rhodiola for improving athletic performance. Overall, it seems that short-term use of some types of rhodiola products might improve measurements of athletic performance. However, neither short-term nor long-term doses seem to improve muscle function or reduce muscle damage due to exercise.
- Low mood. Early research shows that taking rhodiola might improve concerns of low mood after 6-12 weeks of nutritional support in people with mild-to-moderate low mood.
- Fatigue. Early research suggests that rhodiola might decrease fatigue in stressful situations. A specific rhodiola extract seems to decrease fatigue and increase a sense of well-being in students taking exams, night-shift workers, and sleep-deprived military cadets. Other rhodiola extracts also seem to reduce mental fatigue in first-year college students and adults experiencing burnout. There is conflicting evidence regarding a combination product containing rhodiola extract, schisandra berry extract, and Siberian ginseng extract. Some research shows it improves mental performance in tired individuals performing mental tasks. Other research shows it doesn't work.
- A type of persistent stress marked by exaggerated worry and tension (generalized stress imbalance or GAD). Early evidence suggests that specific rhodiola extract might lower stress and low mood in people with a condition called generalized stress imbalance.
- Early orgasm in men (premature ejaculation). Early research suggests that taking a specific product containing rhodiola with other ingredients might slightly increase how long it takes to ejaculate and improve a man's control over ejaculation. But higher quality research is needed to confirm.
- Stress. Early research shows that taking a specific rhodiola extract before breakfast and lunch can improve stress concerns in people with life-stress, college students with stress, and people experiencing burnout.
- Aging.
- Cancer.
- Diabetes.
- Hearing loss.
- High lipid balance.
- Increasing energy.
- Irregular heartbeat.
- Stress-associated heart imbalances.
- Other conditions.
Recommended Dosing
The appropriate dose of rhodiola depends on several factors such as the user's age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for rhodiola. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Rhodiola Supplements Frequently Asked Questions
Can Rhodiola cause weight gain?
In human clinical studies, administration of rhodiola rosea extract, in combination with moderate exercise, produced significant weight loss. Extracts of rhodiola rosea, standardized to a specific level of rosavin, in combination with regular exercise, can accelerate weight loss.
Does Rhodiola interact with any medications?
Rhodiola may alter cardiovascular health and is not recommended for patients taking ACE inhibitors. Rhodiola can also increase the risk of bleeding when it's taken with aspirin or prescription anticoagulants such as warfarin (Coumadin®) or heparin. It is not proven safe with anti-platelet drugs such as clopidogrel (Plavix®).
What is Rhodiola supplement used for?
Today, people use rhodiola as a dietary supplement to increase energy, stamina, and strength, to improve attention and memory, and to enhance the ability to cope with stress. Rhodiola root extracts are also available in capsule or tablet form.
When should I take Rhodiola?
As it has a mild stimulant-type effect, Rhodiola rosea is not recommended for people who have bipolar imbalance or who are taking other stimulants. One article suggests that people can take the herb on an empty stomach 30 minutes before breakfast and lunch.
Can you take Rhodiola every day?
When taken by mouth: Rhodiola is POSSIBLY SAFE when taken short-term. Twice daily doses of rhodiola extract have been used safely for 6-12 weeks. Rhodiola might cause dizziness, dry mouth, or excessive saliva production. There isn't enough reliable information to know if rhodiola is safe to use long-term.
Does Rhodiola raise estrogen levels?
Researchers from the University of Pittsburgh Cancer Institute offer new evidence that herbs such as red clover and motherwort -- traditionally used for gynecological complaints -- as well as saw palmetto and rhodiola rosea root can have such a strong estrogenic effect they could increase the risk of estrogen-related .
Does Rhodiola increase serotonin?
Rhodiola rosea has been classified by some researchers as an adaptogen, meaning that it helps to make you less prone to physical and emotional stress. Limited research has shown that this natural medicine may stimulate serotonin, norepinephrine and dopamine activity.
Does Rhodiola affect hormones?
Rhodiola is also promised to improve memory, help with weight loss, increase energy levels, and boost immunity. It is not safe to take with birth control pills and thyroid medication because rhodiola may contain estrogen receptor-interacting chemicals. Rhodiola rosea is considered an adaptogen.
How quickly does Rhodiola work?
Brain Energy
Some researchers have suggested that Rhodiola's stimulating effects may commence within 30 minutes of taking the herb, and may continue for up to 6 hours. The herb's stress-resistance benefits and stimulating benefits combine to promote energized mental clarity.
Will Rhodiola help me lose weight?
Rhodiola has been proven to help people with all the factors they need to lose weight. It boosts energy. It reduces stress-related mental fatigue. It burns fat.
Can Rhodiola cause hair loss?
Rhodiola enhances the mood through its attempts to normalize levels of important "happy" brain chemicals such as serotonin, norepinephrine and dopamine. Please realize that rhodiola does not make hair grow.
Does Rhodiola make you sleepy?
Folks are commonly encouraged to increase their dose of rhodiola until they achieve the desired effect. Many sources claim it is a safe herb with very little side effects. Most common side effects are difficulty sleeping, drowsiness, gastrointestinal distress, headache, and dizziness.
Is it OK to take Ashwagandha and Rhodiola together?
Ashwagandha and rhodiola are two “must-have” herbal adaptogens that help you thrive during times of mental and physical stress. Together, these amazing botanicals: Sustain your mental and physical energy – without jitteriness. Help you stay focused, even with demanding schedules.
Is Rhodiola a banned substance?
Because Rhodiola is more moderate and isn't on any lists of banned substances, it continues to intrigue modern researchers and athletes around the world. Rhodiola-based products are still widely sold in Eastern European and Asian pharmacies as a remedy for low mood and fatigue.
Does Rhodiola affect the liver?
A Rhodiola extract protected the liver from oxidative-stress-induced damage while a methanolic extract of R. crenulata root extract increased glycogen synthesis and the expression of regulatory enzymes in HepG2 cells and suppressed fat accumulation in hepatic cells under high-glucose conditions.
Does Rhodiola lower cortisol?
Rhodiola suppresses the production of cortisol and increases levels of stress-resistant proteins. Rhodiola also protects the heart and liver, increases use of oxygen, improves memory, and may even extend longevity. Also, new research proves it's effective as a weight loss agent.
Is Rhodiola the same as Ashwagandha?
Both in the case of ashwagandha and rhodiola, it is the root that is used to make medicines. Both herbs are used by herbalists in the fight against stress and fatigue, support the nervous system, increase endurance and solve the problem of infertility.
Is Rhodiola a stimulant?
As it has a mild stimulant-type effect, Rhodiola rosea is not recommended for people who have bipolar imbalance or who are taking other stimulants.
How much Rhodiola should I take for stress?
Some guidance about the adequate dose of Rhodiola rosea for GAD can be extrapolated from clinical trials using specific extracts. A range of doses is seen in such trials, from 100-170 milligrams daily. One author recommends basing dosage recommendations on the content of rosavin, aiming for 3.6-6 milligrams daily.
Clinical Studies
- ^ a b c Colson SN, et al. Cordyceps sinensis- and Rhodiola rosea-based supplementation in male cyclists and its effect on muscle tissue oxygen saturation. J Strength Cond Res. (2005)
- ^ a b Earnest CP, et al. Effects of a commercial herbal-based formula on exercise performance in cyclists. Med Sci Sports Exerc. (2004)
- ^ a b c Skarpanska-Stejnborn A, et al. The influence of supplementation with Rhodiola rosea L. extract on selected redox parameters in professional rowers. Int J Sport Nutr Exerc Metab. (2009)
- ^ Bangratz M, et al. A preliminary assessment of a combination of rhodiola and saffron in the management of mild-moderate low mood. Neuropsychiatr Dis support. (2018)
- ^ a b c d e f g h Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rodakson on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol. (2000)
- ^ Ha Z, et al. The effect of rhodiola and acetazolamide on the sleep architecture and blood oxygen saturation in men living at high altitude. Zhonghua Jie He He Hu Xi Za Zhi. (2002)
- ^ Yu HL, et al. Effects of rhodiola rosea on oxidative stress and negative emotional states in patients with obstructive sleep apnea. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. (2019)
- ^ Shi ZF, et al. Three preparations of compound Chinese herbal medicines for de-adaptation to high altitude: a randomized, placebo-controlled trial. Zhong Xi Yi Jie He Xue Bao. (2011)
- ^ Xu KJ, Zhang SF, Li QX. Preventive and nutritional support effect of composite Rhodiolae on acute lung injury in patients with severe pulmonary hypertension during extracorporeal circulation. Zhongguo Zhong Xi Yi Jie He Za Zhi. (2003)
- ^ Zhang S, et al. Early use of Chinese drug rhodiola compound for patients with post-trauma and physical strain in prevention of ALI/ARDS. Zhonghua Wai Ke Za Zhi. (1999)
- ^ Shen WS, Gao CH, Zhang H. Effect of rhodiola on serum troponin 1, cardiac integral backscatter and left ventricle ejective fraction of patients who received epirubicin-contained chemoroutine. Zhongguo Zhong Xi Yi Jie He Za Zhi. (2010)
- ^ Ballmann CG, et al. Effects of short-term Rhodiola Rosea (Golden Root Extract) supplementation on anaerobic exercise performance. J Sports Sci. (2019)
- ^ Mao Jun, et al. A Randomized Placebo Controlled Trial of Rhodiola Rosea and Sertraline for Major Depressive imbalance.
- ^ a b c d e f g h i j k l m n o p q r s t Rohloff J. Volatiles from rhizomes of Rhodiola rosea L. Phytochemistry. (2002)
- ^ a b c d Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine. (2010)
- ^ a b c Jafari M, et al. Rhodiola: a promising anti-aging Chinese herb. Rejuvenation Res. (2007)
- ^ a b c d e f g h Yousef GG, et al. Comparative phytochemical characterization of three Rhodiola species. Phytochemistry. (2006)
- ^ Effects of Adaptogens on the Central Nervous System and the Molecular Mechanisms associated with their Stress - Protective Activity.
- ^ a b c d Mudge E, et al. Purification of Phenylalkanoids and monoterpene glycosides from rhodiola rosea L. roots by high-speed counter-current chromatography. Phytochem Anal. (2013)
- ^ a b c d Akgul Y, et al. Lotaustralin from Rhodiola rosea roots. Fitoterapia. (2004)
- ^ a b c d Ming DS, et al. Bioactive compounds from Rhodiola rosea (Crassulaceae). Phytother Res. (2005)
- ^ a b Study on separation and purification of oligomeric proanthocyanidin from Rhodiola rosea.
- ^ Extraction and purification of proanthocyanidins from R.Roaea.
- ^ Glycosides of cinnamyl alcohol from the rhizomes of Rhodiola rosea.
- ^ a b c d Guo N, et al. Simultaneous determination of salidroside and its aglycone metabolite p-tyrosol in rat plasma by liquid chromatography-tandem mass spectrometry. Molecules. (2012)
- ^ a b c Panossian A, et al. Adaptogens stimulate neuropeptide y and hsp72 expression and release in neuroglia cells. Front Neurosci. (2012)
- ^ a b Darbinyan V, et al. Clinical trial of Rhodiola rosea L. extract SHR-5 in the nutritional support of mild to moderate low mood. Nord J Psychiatry. (2007)
- ^ a b c Olsson EM, von Schéele B, Panossian AG. A randomised, double-blind, placebo-controlled, parallel-group study of the standardised extract shr-5 of the roots of Rhodiola rosea in the nutritional support of subjects with stress-related fatigue. Planta Med. (2009)
- ^ a b Aslanyan G, et al. Double-blind, placebo-controlled, randomised study of single dose effects of ADAPT-232 on cognitive functions. Phytomedicine. (2010)
- ^ a b c d Sodium-dependent Glucose Transporter Was Involved in Salidroside Absorption in Intestine of Rats.
- ^ Mizuma T, et al. Intestinal active absorption of sugar-conjugated compounds by glucose transport system: implication of improvement of poorly absorbable drugs. Biochem Pharmacol. (1992)
- ^ Morand C, et al. Quercetin 3-O-beta-glucoside is better absorbed than other quercetin forms and is not present in rat plasma. Free Radic Res. (2000)
- ^ Yu S, et al. Development and validation of a liquid chromatographic/electrospray ionization mass spectrometric method for the determination of salidroside in rat plasma: application to the pharmacokinetics study. J Chromatogr B Analyt Technol Biomed Life Sci. (2008)
- ^ Chang YW, et al. Quantitative determination of salidroside in rat plasma by on-line solid-phase extraction integrated with high-performance liquid chromatography/electrospray ionization tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci. (2007)
- ^ Hellum BH, et al. Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta Med. (2010)
- ^ Panossian A, et al. Pharmacokinetic and pharmacodynamic study of interaction of Rhodiola rosea SHR-5 extract with warfarin and theophylline in rats. Phytother Res. (2009)
- ^ a b c d Wiegant FA, et al. Plant adaptogens increase lifespan and stress resistance in C. elegans. Biogerontology. (2009)
- ^ Hormesis and aging in Caenorhabditis elegans.
- ^ McElwee JJ, et al. Evolutionary conservation of regulated longevity assurance mechanisms. Genome Biol. (2007)
- ^ Partridge L, Gems D. Mechanisms of ageing: public or private. Nat Rev Genet. (2002)
- ^ Panossian A, Wikman G. Evidence-based efficacy of adaptogens in fatigue, and molecular mechanisms related to their stress-protective activity. Curr Clin Pharmacol. (2009)
- ^ a b Schriner SE, et al. Decreased mitochondrial superoxide levels and enhanced protection against paraquat in Drosophila melanogaster supplemented with Rhodiola rosea. Free Radic Res. (2009)
- ^ Schriner SE, et al. Extension of Drosophila Lifespan by Rhodiola rosea through a Mechanism Independent from Dietary Restriction. PLoS One. (2013)
- ^ Bayliak MM, Lushchak VI. The golden root, Rhodiola rosea, prolongs lifespan but decreases oxidative stress resistance in yeast Saccharomyces cerevisiae. Phytomedicine. (2011)
- ^ a b van Diermen D, et al. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol. (2009)
- ^ Inhibition of monoamine oxidase and acetylcholinesterase by Rhodiola rosea L.
- ^ a b c d e f