Red Clover
This article provides general nutrition information only and is not medical advice.

Overview
Red clover is a plant. The flower tops are used to make medicine.
Red clover is used for many conditions, but so far, there isn’t enough scientific evidence to determine whether it is effective for any of them. It doesn’t seem to work, though, for lowering lipid balance or controlling hot flashes in women.
Some women use red clover for concerns of life stage such as hot flashes; for breast pain or tenderness (mastalgia); and for premenstrual syndrome (PMS).
In foods and beverages, the solid extract of red clover is used as a flavoring ingredient.
Red clover contains hormone-like chemicals called isoflavones that seem to cause reproductive problems in certain animals. Experts think a diet high in isoflavones may have been responsible for reports of reproductive failure and liver condition in cheetahs living in zoos. In large quantities, red clover can cause sterility in livestock.
Classification
Is a Form of:
Plant
Primary Functions:
Cancer prevention, indigestion, high lipid balance
Also Known As:
Beebread, Clovone, Cow Clover, Daidzein, Genistein, Isoflavone, Meadow Clover
How Does It Work?
Red clover contains “isoflavones” which are changed in the body to “phytoestrogens” that are similar to the hormone estrogen.
Uses
- High lipid balance in women. Research shows that taking red clover extracts by mouth for 3 months to a year does not seem reduce low-density lipoprotein (LDL or “bad”) lipid balance or increase high-density lipoprotein (HDL or “good”) lipid balance in women who have moderately elevated lipid balance levels.
- Weak bones (osteoporosis). Some early research suggests that taking red clover daily for 6 months increased bone mineral density and healthy postmenopausal women. However, most evidence suggests that taking red clover does not improve osteoporosis.
Recommended Dosing
The appropriate dose of red clover depends on several factors such as the user’s age, health, and several other conditions. At this time there is not enough scientific information to determine an appropriate range of doses for red clover. Keep in mind that natural products are not always necessarily safe and dosages can be important. Be sure to follow relevant directions on product labels and consult your pharmacist or physician or other healthcare professional before using.
Red Clover Supplements Frequently Asked Questions
What are the benefits of red clover?
Red clover is used for cancer prevention, indigestion, high lipid balance, whooping cough, cough, asthma, bronchitis, and sexually transmitted conditions (STDs). Some women use red clover for concerns of life stage such as hot flashes; for breast pain or tenderness (mastalgia); and for premenstrual syndrome (PMS).
Does red clover increase estrogen?
Modern scientific tests have shown that red clover contains isoflavones, plant-based chemicals that produce estrogen-like effects in the body. Isoflavones have shown potential in the nutritional support of several conditions associated with life stage, such as hot flashes, cardiovascular health, and osteoporosis.
Does Red Clover make you gain weight?
(Reuters Health) - Plant-derived estrogens, such as those from soy and red clover, might contribute to unwanted weight gain in some postmenopausal women, according to a new review of previous clinical trials. Known as phytoestrogens, these natural compounds mimic the effects of estrogen in the body.
Is red clover good for hair growth?
"The biochanin A found in the red clover extract inhibits the 5-alpha reductase activity responsible for androgenic alopecia." The combined effect of the two active ingredients is to inhibit hair-follicle shrinkage and improve hair anchoring.
How long does it take for red clover to work?
It's effectiveness for treating hot flashes, or hot flushes, was established based on two randomized clinical trials with a total of 1174 women over the course of 12 weeks and 24 weeks.
Is red clover safe to take?
Side Effects & Safety
Red clover is LIKELY SAFE for most people when used in the amounts found in food. It is POSSIBLY SAFE when used in medicinal amounts by mouth or applied to the skin. Red clover can cause rash-like reactions, muscle ache, headache, nausea, and vaginal bleeding (spotting) in some women.
Does Red Clover balance hormones?
Pregnancy and breast-feeding: Red clover is LIKELY SAFE when taken by mouth in amounts commonly found in food. However, it is LIKELY UNSAFE when taken by mouth in medicinal amounts. Red clover acts like estrogen and might disturb important hormone balances during pregnancy or breast-feeding.
Which is better red clover or black cohosh?
The red clover group had a 57% reduction in hot flashes (from 58 to 25), and the black cohosh group had the smallest reduction in vasomotor concerns, 34% (from 65 to 43). Although this trial found a 57% reduction in vasomotor concerns with red clover, the effect was no better than that observed in women using placebo.
What are the side effects of taking red clover?
What Are Side Effects Associated with Using Red Clover?
- estrogen-like effects (bloating, breast tenderness, irregular menstrual periods, decreased sex drive, weight gain, mood changes)
- muscle ache.
- vaginal bleeding/spotting.
How often should you drink red clover tea?
hot water for 1/2 hour; drink 2 to 3 cups daily. Powdered herb (available in capsules): 40 to 160 mg per day, or 28 to 85 mg of red clover isoflavones. Tincture (1:5, 30% alcohol): 60 to 100 drops (3 to 5 mL), 3 times per day; may add to hot water as a tea.
Does Red Clover lower testosterone?
The effect of red clover on testosterone levels
To sum up, red clover may increase testosterone levels. Further studies are needed to clarify this effect of red clover on testosterone levels.
How do you get rid of red clover?
Red clover can be effectively killed by herbicide application, mechanical means or a combination of the two. Herbicides can be used to kill red clover in conservation and no-till tillage systems. A table of applicable herbicides in wheat has been compiled in Using Red Clover as a Cover Crop in Wheat.
Is red clover bad for your hair?
"The biochanin A found in the red clover extract inhibits the 5-alpha reductase activity responsible for androgenic alopecia." The combined effect of the two active ingredients is to inhibit hair-follicle shrinkage and improve hair anchoring.
How much red clover should I take?
Powdered herb (available in capsules): 40 to 160 mg per day, or 28 to 85 mg of red clover isoflavones. Tincture (1:5, 30% alcohol): 60 to 100 drops (3 to 5 mL), 3 times per day; may add to hot water as a tea. Fluid Extract (1:1): 1 mL, 3 times per day; may add to hot water as a tea.
Is crimson clover the same as red clover?
Crimson clover has taller flower stems, grows more quickly and has larger seeds than the more commonly used red clover. Crimson clover's primary advantages are rapid growth during cool weather, shade tolerance and a positive reseeding potential.
Is red clover good for skin?
Red clover is used for cancer prevention, indigestion, high lipid balance, whooping cough, cough, asthma, bronchitis, and sexually transmitted conditions (STDs). Red clover is applied to the skin for skin cancer, skin sores, burns, and chronic skin conditions including eczema and psoriasis.
How does red clover help fertility?
Red Clover: Red clover is estrogen's twin hormonally. Though not identical, they can both serve the same purpose, as red clover helps to thicken the uterine lining, which leads to better implantation and increases your fertility.
Is red clover good for the liver?
Red clover. Red clover is a wild plant belonging to the legume family. Health care practitioners believe that red clover "purified" the blood by acting as a diuretic (helping the body get rid of excess fluid) and expectorant (helping clear lungs of mucous), improving circulation, and helping cleanse the liver.
Does Red Clover cause liver damage?
Clover toxicity is caused by ingestion of alsike clover (Trifolium hybridum) or red clover (Trifolium pratense), resulting in signs of photosensitivity and liver failure.
Is red clover toxic?
More commonly known as black patch for the bronze to black spots it creates on the stems and leaves, the fungus is likely to be found on either white or red clover. The clover plants themselves are non-toxic and it is the fungus that contains the toxin slaframine that causes the undesirable concerns in horses.
Does Red Clover reduce estrogen?
Several studies of a proprietary extract of red clover isoflavones suggest that it may significantly reduce hot flashes in menopausal women. However, the largest study showed no effect. As estrogen levels drop during life stage, a woman's risk for developing osteoporosis (significant bone loss) goes up.
Is red clover good for life stage?
Theoretically, red clover is said to be beneficial for a number of menopausal concerns including hot flushes, night sweats, bone health, heart health, skin physical strain, and respiratory immune challenge, as well as breast pain, indigestion, sexually transmitted immune challenges, and hair loss.
Does red clover winter kill?
Ontario fertilizer recommendations for corn use a 60-73 lb N/ac credit following red clover seeded into winter wheat (the higher number were killed by tillage, the lower were killed by herbicide alone — both operations done in the fall). There is a shorter fall growth period than in Ontario.
Can I take red clover with HRT?
Women may wish to start a herbal remedy such as red clover tablets while taking the lowest dosage of HRT. Only red clover has an evidence base to show it reduces menopausal hot flushes, stress and low mood. A recent article summarised the lack of evidence of most alternative therapies.
Clinical Studies
- ^Loing E, et al. A new strategy to modulate alopecia using a combination of two specific and unique ingredients. J Cosmet Sci. (2013)
- ^ ab c Engelmann NJ, et al. In Vitro Production of Radiolabeled Red Clover (Trifolium pratense) Isoflavones. Plant Cell Tissue Organ Cult. (2009)
- ^Cassidy A, Bingham S, Setchell KD. Biological effects of a diet of soy protein rich in isoflavones on the menstrual cycle of premenopausal women. Am J Clin Nutr. (1994)
- ^ ab c d e Ko WC, et al. Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. Evid Based Complement Alternat Med. (2011)
- ^ ab c d e f g h i j k l m n o p q r Wu Q, Wang M, Simon JE. Determination of isoflavones in red clover and related species by high-performance liquid chromatography combined with ultraviolet and mass spectrometric detection. J Chromatogr A. (2003)
- ^ ab c d e f g h Atkinson C, et al. Red-clover-derived isoflavones and mammographic breast density: a double-blind, randomized, placebo-controlled trial {ISRCTN42940165}. Breast Cancer Res. (2004)
- ^ ab c d e van de Weijer PH, Barentsen R. Isoflavones from red clover (Promensil) significantly reduce menopausal hot flush concerns compared with placebo. Maturitas. (2002)
- ^ ab c d e f Baber RJ, et al. Randomized placebo-controlled trial of an isoflavone supplement and menopausal concerns in women. Climacteric. (1999)
- ^ ab c d e Knight DC, Howes JB, Eden JA. The effect of Promensil, an isoflavone extract, on menopausal concerns. Climacteric. (1999)
- ^ ab c Vrieling A, et al. Isolated isoflavones do not affect the circulating insulin-like growth factor system in men at increased colorectal cancer risk. J Nutr. (2007)
- ^ ab c Vrieling A, et al. No effect of red clover-derived isoflavone intervention on the insulin-like growth factor system in women at increased risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev. (2008)
- ^ ab c d e f g Schult TM, et al. Effect of isoflavones on lipids and bone turnover markers in menopausal women. Maturitas. (2004)
- ^ ab c Nestel PJ, et al. Isoflavones from red clover improve systemic arterial compliance but not plasma lipids in menopausal women. J Clin Endocrinol Metab. (1999)
- ^ ab c d e Teede HJ, et al. Isoflavones reduce arterial stiffness: a placebo-controlled study in men and postmenopausal women. Arterioscler Thromb Vasc Biol. (2003)
- ^ ab c Chedraui P, et al. Red clover extract (MF11RCE) supplementation and postmenopausal vaginal and sexual health. Int J Gynaecol Obstet. (2006)
- ^ ab c Wang Y, et al. The red clover (Trifolium pratense) isoflavone biochanin A inhibits aromatase activity and expression. Br J Nutr. (2008)
- ^ ab c d Tolleson WH, et al. Metabolism of biochanin A and formononetin by human liver microsomes in vitro. J Agric Food Chem. (2002)
- ^ ab Roberts DW, et al. Inhibition of extrahepatic human cytochromes P450 1A1 and 1B1 by metabolism of isoflavones found in Trifolium pratense (red clover). J Agric Food Chem. (2004)
- ^ ab c d e Nestel P, et al. A biochanin-enriched isoflavone from red clover lowers LDL lipid balance in men. Eur J Clin Nutr. (2004)
- ^ ab van Meeuwen JA, et al. (Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture. Toxicol Appl Pharmacol. (2007)
- ^Jeong HJ, et al. Inhibition of aromatase activity by flavonoids. Arch Pharm Res. (1999)
- ^Kao YC, et al. Molecular basis of the inhibition of human aromatase (estrogen synthetase) by flavone and isoflavone phytoestrogens: A site-directed mutagenesis study. Environ Health Perspect. (1998)
- ^Orr A, Parker R. Red clover causing concerns suggestive of methotrexate toxicity in a patient on high-dose methotrexate. life stage Int. (2013)
- ^VanWert AL, Sweet DH. Impaired clearance of methotrexate in organic anion transporter 3 (Slc22a8) knockout mice: a gender specific impact of reduced folates. Pharm Res. (2008)
- ^Vlaming ML, et al. Impact of abcc2 {multidrug resistance-associated protein (MRP) 2}, abcc3 (MRP3), and abcg2 (breast cancer resistance protein) on the oral pharmacokinetics of methotrexate and its main metabolite 7-hydroxymethotrexate. Drug Metab Dispos. (2011)
- ^Breedveld P, et al. Mechanism of the pharmacokinetic interaction between methotrexate and benzimidazoles: potential role for breast cancer resistance protein in clinical drug-drug interactions. Cancer Res. (2004)
- ^Barnhart K, Coutifaris C, Esposito M. The pharmacology of methotrexate. Expert Opin Pharmacother. (2001)
- ^ ab Geller SE, et al. Safety and efficacy of black cohosh and red clover for the management of vasomotor concerns: a randomized controlled trial. life stage. (2009)
- ^Lipovac M, et al. Improvement of postmenopausal depressive and stress concerns after nutritional support with isoflavones derived from red clover extracts. Maturitas. (2010)
- ^ ab c d e Lipovac M, et al. Effect of Red Clover Isoflavones over Skin, Appendages, and Mucosal Status in Postmenopausal Women. Obstet Gynecol Int. (2011)
- ^Ehsanpour S, et al. The effects of red clover on quality of life in post-menopausal women. Iran J Nurs Midwifery Res. (2012)
- ^ ab Howes JB, et al. The effects of dietary supplementation with isoflavones from red clover on cognitive function in postmenopausal women. Climacteric. (2004)
- ^ ab c d Howes JB, et al. Effects of dietary supplementation with isoflavones from red clover on ambulatory cardiovascular health and endothelial function in postmenopausal type 2 diabetes. Diabetes Obes Metab. (2003)
- ^Nagata C, et al. Soy product intake is inversely associated with serum homocysteine level in premenopausal Japanese women. J Nutr. (2003)
- ^Samman S, et al. Red clover (Trifolium pratense) isoflavones and serum homocysteine in premenopausal women: a pilot study. J Womens Health (Larchmt). (2009)
- ^ ab c d e f g h i j Hidalgo LA, et al. The effect of red clover isoflavones on menopausal concerns, lipids and vaginal cytology in menopausal women: a randomized, double-blind, placebo-controlled study. Gynecol Endocrinol. (2005)
- ^ ab c d Howes JB, et al. The effects of dietary supplementation with isoflavones from red clover on the lipoprotein profiles of post menopausal women with mild to moderate hyperlipid balanceaemia. Atherosclerosis. (2000)
- ^ ab c Atkinson C, et al. Modest protective effects of isoflavones from a red clover-derived dietary supplement on cardiovascular condition risk factors in perimenopausal women, and evidence of an interaction with ApoE genotype in 49-65 year-old women. J Nutr. (2004)
- ^ ab c Chedraui P, et al. Effect of Trifolium pratense-derived isoflavones on the lipid profile of postmenopausal women with increased body mass index. Gynecol Endocrinol. (2008)
- ^ ab c Blakesmith SJ, et al. Effects of supplementation with purified red clove