Licorice
Overview
Licorice is an herb that grows in parts of Europe and Asia. The root is used as medicine. Licorice root contains glycyrrhizic acid. Glycyrrhizic acid can cause complications when eaten in large quantities. Many "licorice" products manufactured in the U.S. actually don't contain any licorice. Instead, they contain anise oil, which has the characteristic smell and taste of "black licorice."
Licorice is used for eczema, swelling (inflammation) of the liver (hepatitis), mouth sores, and many other conditions, but there is no good scientific evidence to support most of these uses.
Licorice is also used to flavor foods, beverages, and tobacco products.
Classification
Is a Form of:
Herb
Primary Functions:
Eczema
Also Known As:
Can Cao, Chinese Licorice, Deglycyrrhized Licorice
How Does It Work?
The chemicals contained in licorice are thought to decrease swelling, thin mucus secretions, decrease cough, and increase the chemicals in our body that heal ulcers.
Uses
- Eczema (atopic dermatitis). There is some evidence that applying licorice to the skin can improve symptoms of eczema. Applying a gel containing licorice three times daily for 2 weeks seems to reduce redness, swelling, and itching.
- Side effects in people after breathing tube removal. Sucking on a licorice lozenge or gargling with a licorice fluid shortly before placement of a breathing tube seems to help prevent cough and sore throat from occurring when the tube is removed.
Recommended Dosing
The following doses have been studied in scientific research:
APPLIED TO THE SKIN:
- For eczema (atopic dermatitis): Gel products containing 1% or 2% licorice root extract have been applied three times daily for 2 weeks.
- For side effects in people after breathing tube removal: A lozenge containing 97 mg of licorice has been sucked for 30 minutes before anesthesia. Gargling with 30 mL of a fluid containing 0.5 grams of licorice for at least one minute beginning 5 minutes before placement of a breathing tube, has been used.
Licorice Supplements Frequently Asked Questions
What are the benefits of licorice?
Licorice root may have potent antioxidant, anti-inflammatory, and antimicrobial effects. Early research suggests that, as a result, it may ease upper respiratory infections, treat ulcers, and aid digestion, among other benefits.
It may:
- Aid diabetes.
- Reduce menopause symptoms.
- Boost weight loss.
- Help treat hepatitis C.
What are the side effects of licorice?
Common side effects of licorice include:
- Absence of a menstrual period.
- Congestive heart failure.
- Decreased sexual interest (libido)
- Erectile dysfunction.
- Excess fluid in the lungs (pulmonary edema)
- Fluid and sodium retention.
- High blood pressure (hypertension)
Why is licorice bad for you?
Yes, particularly if you're over 40 and have a history of heart disease or high blood pressure, or both. Eating more than 57g (2 ounces) of black liquorice a day for at least 2 weeks could lead to potentially serious health problems, such as an increase in blood pressure and an irregular heart rhythm (arrhythmia).
How much licorice is safe?
In 1994, Walker and Edwards demonstrated that a daily oral intake of 1–10 mg of glycyrrhizin, which corresponds to 1–5 g licorice, has been estimated to be a safe dose for most healthy adults [Walker and Edwards, 1994]. Two studies on healthy volunteers were published.
Does liquorice make you poop?
Liquorice has several varied uses in herbal medicine, such as acting as a mild laxative by increasing prostaglandins. Some people report that black liquorice confectionery causes their stools to become green, although this is probably due to the blue food colouring used by many manufacturers.
Is licorice bad for your heart?
Black licorice contains the sweetening compound glycyrrhizin, which can decrease potassium levels in the body, according to the US Food and Drug Administration. That temporary potassium deficiency can cause abnormal heart rhythms, high blood pressure, and even congestive heart failure.
Who should not eat licorice?
FDA says no one, young or old, should eat big quantities of black licorice at a time and advises anyone who has an irregular heart rhythm or muscle weakness to stop eating the candy immediately. Pregnant women should also avoid eating black licorice, the National Center for Complementary and Integrative Health advises.
Does licorice help you sleep?
But research conducted on mice in 2012 published in the journal Bioorganic Medicine and Chemistry found that the active ingredient in liquorice called gabrol, a flavonoid, could help bind to GABA receptors in the brain which stimulate relaxing alpha waves and led to the mice in the study getting deeper and longer sleep.
Is Panda Licorice real licorice?
Panda Made from All Natural Ingredients Soft Licorice. The real taste of Licorice, Fat free, No preservatives, No artificial colors, No artificial flavors. Made with real licorice root extract.
Is licorice a healthy snack?
Afternoon Snack: The Surprising Health Benefit of Black Licorice! If so, you're going to love this news: German researchers have found that the so-called "amorfrutins" in licorice root may reduce blood sugar and have anti-inflammatory properties, which could be great for diabetics.
Is licorice bad for kidneys?
Consumption of licorice (liquorice) can lead to dangerously high blood pressure and dangerously low potassium levels (hypokalemia). But cortisol is not part of the aldosterone/potassium feedback loop, so the ability of cortisol to act on the kidneys is a bad thing that could lead to abnormally low potassium.
Why is black licorice so nasty?
When we bite into a piece of licorice, we taste glycyrrhizin, a natural sweetener in licorice root, which can taste, to some, like saccharin, the artificial sweetener found in Sweet 'n' Low. With licorice, this sickly sweet lingers, causing some to wrinkle their noses in displeasure.
Do black Twizzlers have real licorice?
"It's just artificial flavoring. Thus, it contains no glycyrrhizin.” Twizzlers Black Licorice Twists, for example, gets its flavor from licorice extract, which is derived from licorice root as well as added natural and artificial flavors, according to Jeff Beckman, a spokesperson for Hershey which produces Twizzlers.
How much is too much licorice?
Yes, particularly if you're over 40 and have a history of heart disease or high blood pressure, or both. Eating more than 57g (2 ounces) of black liquorice a day for at least 2 weeks could lead to potentially serious health problems, such as an increase in blood pressure and an irregular heart rhythm (arrhythmia).
Is licorice an antiviral?
Licorice contains more than 20 triterpenoids and nearly 300 flavonoids. Among them, only two triterpenes, GL and GA have been reported to have antiviral effects. They can weaken virus activities by inhibiting virus gene expression and replication, reducing adhesion force and stress, and reducing HMGB1 binding to DNA.
Is licorice good for losing weight?
Vital Information: New research shows that eating licorice may reduce body fat without any side effects. Two proposed theories are that the strong taste of licorice suppresses the appetite, and that eating licorice makes people feel full, so they eat fewer calories.
Does black licorice have any health benefits?
Soothes your stomach
Licorice root is used to soothe gastrointestinal problems. In cases of food poisoning, stomach ulcers, and heartburn, licorice root extract can speed the repair of stomach lining and restore balance. This is due to the anti-inflammatory and immune-boosting properties of glycyrrhizic acid.
Does licorice lower BP?
Yes. Consumption of licorice (liquorice) can lead to dangerously high blood pressure and dangerously low potassium levels (hypokalemia). Licorice contains glycyrrhizinic acid, which sets off a well-understood chain reaction of biochemical events in the body resulting in high blood pressure.
Can you overdose on licorice?
As it turns out, you really can overdose on candy—or, more precisely, black licorice. If you're 40 or older, eating 2 ounces of black licorice a day for at least two weeks could land you in the hospital with an irregular heart rhythm or arrhythmia.
Can Licorice cause heart palpitations?
The ingredient is made from licorice root, consumption of which can prompt the kidneys to release too much potassium, disrupting cardiac function and sometimes causing palpitations. Shortly before Halloween 2011, the Food and Drug Administration cautioned consumers to avoid overconsumption of black licorice.
Is Twizzlers licorice bad for you?
The problem, experts say, is that the classic candy contains glycyrrhizin, a sweetening compound derived from licorice root, which can cause potassium levels in the body to fall. Any Twizzlers Black Licorice products that contain licorice extract lists this ingredient on the package,” Beckman said.
Is licorice good for acid reflux?
DGL for acid reflux. One such option is deglycyrrhizinated licorice (DGL). People believe that using this a few times per day will alleviate acid reflux symptoms. Acid reflux occurs when the lower esophageal sphincter (LES) fails to close completely.
Clinical Studies
- ^ ab The effect of an endogenous antioxidant glabridin on oxidized LDL.
- ^Combined extractives of red yeast rice, bitter gourd, chlorella, soy protein, and licorice improve total cholesterol, low-density lipoprotein cholesterol, and triglyceride in subjects with metabolic syndrome.
- ^Effects of two natural medicine formulations on irritable bowel syndrome symptoms: a pilot study.
- ^ ab Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity as evaluated by power spectral analysis of HRV and cardiac depolarization-repolarization process.
- ^ ab c Effect of the combination of ginseng, oriental bezoar and glycyrrhiza on autonomic nervous activity and immune system under mental arithmetic stress.
- ^ ab c d e f Clinical safety of licorice flavonoid oil (LFO) and pharmacokinetics of glabridin in healthy humans.
- ^ ab Treatment of polycystic ovary syndrome with spironolactone plus licorice.
- ^ ab Farag MA, Wessjohann LA. Volatiles Profiling in Medicinal Licorice Roots Using Steam Distillation and Solid-Phase Microextraction (SPME) Coupled to Chemometrics. J Food Sci. (2012)
- ^ ab c d e f g h Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol. (2006)
- ^ ab c Scientific Opinion on the safety of “Glavonoid®”, an extract derived from the roots or rootstock of Glycyrrhiza glabra L., as a Novel Food ingredient.
- ^ ab Ploeger B, et al. The pharmacokinetics of glycyrrhizic acid evaluated by physiologically based pharmacokinetic modeling. Drug Metab Rev. (2001)
- ^Das D, Agarwal SK, Chandola HM. Protective effect of Yashtimadhu (Glycyrrhiza glabra) against side effects of radiation/chemotherapy in head and neck malignancies. Ayu. (2011)
- ^Shen L, et al. Characterization using LC/MS of the absorption compounds and metabolites in rat plasma after oral administration of a single or mixed decoction of Shaoyao and Gancao. Chem Pharm Bull (Tokyo). (2012)
- ^ ab c d Sato Y, et al. Isoliquiritigenin, one of the antispasmodic principles of Glycyrrhiza ularensis roots, acts in the lower part of intestine. Biol Pharm Bull. (2007)
- ^ ab c d e Cao J, et al. Role of P-glycoprotein in the intestinal absorption of glabridin, an active flavonoid from the root of Glycyrrhiza glabra. Drug Metab Dispos. (2007)
- ^ ab Chinese Materia Medica: Chemistry, Pharmacology and Applications.
- ^ ab c Wang ZY, Nixon DW. Licorice and cancer. Nutr Cancer. (2001)
- ^Hu C, et al. Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. (2009)
- ^ ab Sabbioni C, et al. Simultaneous HPLC analysis, with isocratic elution, of glycyrrhizin and glycyrrhetic acid in liquorice roots and confectionery products. Phytochem Anal. (2006)
- ^ ab Wang YC, Yang YS. Simultaneous quantification of flavonoids and triterpenoids in licorice using HPLC. J Chromatogr B Analyt Technol Biomed Life Sci. (2007)
- ^Gantait A, et al. Quantification of glycyrrhizin in Glycyrrhiza glabra extract by validated HPTLC densitometry. J AOAC Int. (2010)
- ^Duval N, et al. Cell coupling and Cx43 expression in embryonic mouse neural progenitor cells. J Cell Sci. (2002)
- ^ ab Tian M, Yan H, Row KH. Extraction of glycyrrhizic acid and glabridin from licorice. Int J Mol Sci. (2008)
- ^Hayashi H, et al. Field survey of Glycyrrhiza plants in Central Asia (3). Chemical characterization of G. glabra collected in Uzbekistan. Chem Pharm Bull (Tokyo). (2003)
- ^ ab Vaya J, Belinky PA, Aviram M. Antioxidant constituents from licorice roots: isolation, structure elucidation and antioxidative capacity toward LDL oxidation. Free Radic Biol Med. (1997)
- ^ ab c d e f Cho S, et al. Hypnotic effects and GABAergic mechanism of licorice (Glycyrrhiza glabra) ethanol extract and its major flavonoid constituent glabrol. Bioorg Med Chem. (2012)
- ^Hong YH, et al. Phytoestrogenic compounds in alfalfa sprout (Medicago sativa) beyond coumestrol. J Agric Food Chem. (2011)
- ^ ab c Kusano A, et al. Inhibition of adenosine 3′,5′-cyclic monophosphate phosphodiesterase by flavonoids from licorice roots and 4-arylcoumarins. Chem Pharm Bull (Tokyo). (1991)
- ^ ab Hatano T, et al. Phenolic constituents of licorice. II. Structures of licopyranocoumarin, licoarylcoumarin and glisoflavone, and inhibitory effects of licorice phenolics on xanthine oxidase. Chem Pharm Bull (Tokyo). (1989)
- ^Shibano M, et al. Determination of flavonoids in licorice using acid hydrolysis and reversed-phase HPLC and evaluation of the chemical quality of cultivated licorice. Planta Med. (2010)
- ^ ab c d Seon MR, et al. Hexane/ethanol extract of Glycyrrhiza uralensis and its active compound isoangustone A induce G1 cycle arrest in DU145 human prostate and 4T1 murine mammary cancer cells. J Nutr Biochem. (2012)
- ^Kim SS, et al. Licochalcone E activates Nrf2/antioxidant response element signaling pathway in both neuronal and microglial cells: therapeutic relevance to neurodegenerative disease. J Nutr Biochem. (2012)
- ^Kolbe L, et al. Anti-inflammatory efficacy of Licochalcone A: correlation of clinical potency and in vitro effects. Arch Dermatol Res. (2006)
- ^Yo YT, et al. Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway. J Agric Food Chem. (2009)
- ^Franceschelli S, et al. Licocalchone-C extracted from Glycyrrhiza glabra inhibits lipopolysaccharide-interferon-γ inflammation by improving antioxidant conditions and regulating inducible nitric oxide synthase expression. Molecules. (2011)
- ^Zhang HC, et al. Up-regulation of licochalcone A biosynthesis and secretion by Tween 80 in hairy root cultures of Glycyrrhiza uralensis Fisch. Mol Biotechnol. (2011)
- ^Shimizu N, et al. A novel neutral polysaccharide having activity on the reticuloendothelial system from the root of Glycyrrhiza uralensis. Chem Pharm Bull (Tokyo). (1990)
- ^Tomoda M, et al. Characterization of two polysaccharides having activity on the reticuloendothelial system from the root of Glycyrrhiza uralensis. Chem Pharm Bull (Tokyo). (1990)
- ^Shimizu N, et al. The core structure and immunological activities of glycyrrhizan UA, the main polysaccharide from the root of Glycyrrhiza uralensis. Chem Pharm Bull (Tokyo). (1992)
- ^Zhao JF, et al. Heterogeneity and characterisation of mitogenic and anti-complementary pectic polysaccharides from the roots of Glycyrrhiza uralensis Fisch et D.C. Carbohydr Res. (1991)
- ^Takada K, Tomoda M, Shimizu N. Core structure of glycyrrhizan GA, the main polysaccharide from the stolon of Glycyrrhiza glabra var. glandulifera; anti-complementary and alkaline phosphatase-inducing activities of the polysaccharide and its degradation products. Chem Pharm Bull (Tokyo). (1992)
- ^Shimizu N, et al. Characterization of a polysaccharide having activity on the reticuloendothelial system from the stolon of Glycyrrhiza glabra var. glandulifera. Chem Pharm Bull (Tokyo). (1991)
- ^Yang G, Yu Y. Immunopotentiating effect of traditional Chinese drugs--ginsenoside and glycyrrhiza polysaccharide. Proc Chin Acad Med Sci Peking Union Med Coll. (1990)
- ^Ao M, et al. Factors influencing glabridin stability. Nat Prod Commun. (2010)
- ^ ab c Albermann ME, et al. Determination of glycyrrhetic acid after consumption of liquorice and application to a fatality. Forensic Sci Int. (2010)
- ^Interaction of licorice on glycyrrhizin pharmacokinetics.
- ^Licorice abuse: time to send a warning message.
- ^Recent progress in the consideration of flavoring ingredients under the food additives amendment III.
- ^ ab c Bell ZW, Canale RE, Bloomer RJ. A dual investigation of the effect of dietary supplementation with licorice flavonoid oil on anthropometric and biochemical markers of health and adiposity. Lipids Health Dis. (2011)
- ^ ab c d Choi HJ, et al. Hexane/ethanol extract of Glycyrrhiza uralensis licorice suppresses doxorubicin-induced apoptosis in H9c2 rat cardiac myoblasts. Exp Biol Med (Maywood). (2008)
- ^ ab c d Ito C, et al. Absorption of dietary licorice isoflavan glabridin to blood circulation in rats. J Nutr Sci Vitaminol (Tokyo). (2007)
- ^ ab c d e f Yu XY, et al. Role of P-glycoprotein in limiting the brain penetration of glabridin, an active isoflavan from the root of Glycyrrhiza glabra. Pharm Res. (2007)
- ^Yamamura Y, et al. Administration-route dependency of absorption of glycyrrhizin in rats: intraperitoneal administration dramatically enhanced bioavailability. Biol Pharm Bull. (1995)
- ^Wang Z, et al. Gastrointestinal absorption characteristics of glycyrrhizin from glycyrrhiza extract. Biol Pharm Bull. (1995)
- ^Gunnarsdóttir S, Jóhannesson T. Glycyrrhetic acid in human blood after ingestion of glycyrrhizic acid in licorice. Pharmacol Toxicol. (1997)
- ^Yamamura Y, et al. Pharmacokinetic profile of glycyrrhizin in healthy volunteers by a new high-performance liquid chromatographic method. J Pharm Sci. (1992)
- ^Raggi MA, et al. Bioavailability of glycyrrhizin and licorice extract in rat and human plasma as detected by a HPLC method. Pharmazie. (1994)
- ^Akao T, et al. Intestinal bacterial hydrolysis is indispensable to absorption of 18 beta-glycyrrhetic acid after oral administration of glycyrrhizin in rats. J Pharm Pharmacol. (1994)
- ^ ab Takeda S, et al. Bioavailability study of glycyrrhetic acid after oral administration of glycyrrhizin in rats; relevance to the intestinal bacterial hydrolysis. J Pharm Pharmacol. (1996)
- ^ ab Zhao WJ, et al. Determination of glycyrrhetic acid in human plasma by HPLC-MS method and investigation of its pharmacokinetics. J Clin Pharm Ther. (2008)
- ^ ab Aoki F, et al. Determination of glabridin in human plasma by solid-phase extraction and LC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. (2005)
- ^Monti S, et al. Licochalcone A bound to bovine serum albumin: a spectroscopic, photophysical and structural study. Photochem Photobiol Sci. (2009)
- ^Monti S, et al. Structure and properties of licochalcone A-human serum albumin complexes in solution: a spectroscopic, photophysical and computational approach to understand drug-protein interaction. Phys Chem Chem Phys. (2008)
- ^Akao T. Distribution of enzymes involved in the metabolism of glycyrrhizin in various organs of rat. Biol Pharm Bull. (1998)
- ^ ab Kato H, et al. 3-Monoglucuronyl-glycyrrhetinic acid is a major metabolite that causes licorice-induced pseudoaldosteronism. J Clin Endocrinol Metab. (1995)
- ^ ab c The Metabolism of Carbenoxolone in the Rat.
- ^ ab Wang AX, et al. C5-hydroxylation of liquiritigenin is catalyzed selectively by CYP1A2. Xenobiotica. (2011)
- ^Kupfer R, et al. Oxidative in vitro metabolism of liquiritigenin, a bioactive compound isolated from the Chinese herbal selective estrogen beta-receptor agonist MF101. Drug Metab Dispos. (2008)
- ^Nikolic D, van Breemen RB. New metabolic pathways for flavanones catalyzed by rat liver microsomes. Drug Metab Dispos. (2004)
- ^ ab c Zeng CX, Yang Q, Hu Q. A comparison of the distribution of two glycyrrhizic acid epimers in rat tissues. Eur J Drug Metab Pharmacokinet. (2006)
- ^Ploeger B, et al. A human physiologically-based model for glycyrrhzic acid, a compound subject to presystemic metabolism and enterohepatic cycling. Pharm Res. (2000)
- ^Hou YC, Lin SP, Chao PD. Liquorice reduced cyclosporine bioavailability by activating P-glycoprotein and CYP 3A. Food Chem. (2012)
- ^ ab Nabekura T, et al. Inhibition of P-glycoprotein and multidrug resistance protein 1 by dietary phytochemicals. Cancer Chemother Pharmacol. (2008)
- ^ ab c d Kent UM, et al. The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9. Drug Metab Dispos. (2002)
- ^Guo B, et al. Deglycosylation of Liquiritin Strongly Enhances its Inhibitory Potential Towards UDP-Glucuronosyltransferase (UGT) Isoforms. Phytother Res. (2012)
- ^ ab Kawakami Z, Ikarashi Y, Kase Y. Isoliquiritigenin is a novel NMDA receptor antagonist in kampo medicine yokukansan. Cell Mol Neurobiol. (2011)
- ^Kawakami Z, et al. Yokukansan, a kampo medicine, protects against glutamate cytotoxicity due to oxidative stress in PC12 cells. J Ethnopharmacol. (2011)
- ^Jeon JP, et al. Proteomic and behavioral analysis of response to isoliquiritigenin in brains of acute cocaine treated rats. J Proteome Res. (2008)
- ^Jang EY, et al. Isoliquiritigenin suppresses cocaine-induced extracellular dopamine release in rat brain through GABA(B) receptor. Eur J Pharmacol. (2008)
- ^Jang EY, et al. Liquiritigenin decreases selective molecular and behavioral effects of cocaine in rodents. Curr Neuropharmacol. (2011)
- ^ ab c d e f Lee JW, et al. AMPK activation with glabridin ameliorates adiposity and lipid dysregulation in obesity. J Lipid Res. (2012)
- ^Yi PL, et al. The involvement of serotonin receptors in suanzaorentang-induced sleep alteration. J Biomed Sci. (2007)
- ^Park SH, et al. Glabridin inhibits lipopolysaccharide-induced activation of a microglial cell line, BV-2, by blocking NF-kappaB and AP-1. Phytother Res. (2010)
- ^Lin Z, et al. Traditional chinese medicine for senile dementia. Evid Based Complement Alternat Med. (2012)
- ^Ahn J, et al. Protective effects of Glycyrrhiza uralensis Fisch. on the cognitive deficits caused by beta-amyloid peptide 25-35 in young mice. Biogerontology. (2006)
- ^Hwang IK, et al. Neuroprotective effects of roasted licorice, not raw form, on neuronal injury in gerbil hippocampus after transient forebrain ischemia. Acta Pharmacol Sin. (2006)
- ^ ab c Dhingra D, Parle M, Kulkarni SK. Memory enhancing activity of Glycyrrhiza glabra in mice. J Ethnopharmacol. (2004)
- ^Parle M, Dhingra D, Kulkarni SK. Memory-strengthening activity of Glycyrrhiza glabra in exteroceptive and interoceptive behavioral models. J Med Food. (2004)
- ^ ab Cerebroprotective effect of Glycyrrhiza glabra Linn. root extract.
- ^Cui YM, et al. Effect of glabridin from Glycyrrhiza glabra on learning and memory in mice. Planta Med. (2008)
- ^Yu XQ, et al. In vitro and in vivo neuroprotective effect and mechanisms of glabridin, a major active isoflavan from Glycyrrhiza glabra (licorice). Life Sci. (2008)
- ^ ab Hasanein P. Glabridin as a major active isoflavan from Glycyrrhiza glabra (licorice) reverses learning and memory deficits in diabetic rats. Acta Physiol Hung. (2011)
- ^ ab Liu RT, et al. Liquiritigenin attenuates the learning and memory deficits in an amyloid protein precursor transgenic mouse model and the underlying mechanisms. Eur J Pharmacol. (2011)
- ^Liu RT, et al. Effects of liquiritigenin treatment on the learning and memory deficits induced by amyloid beta-peptide (25-35) in rats. Behav Brain Res. (2010)
- ^Dhingra D, Parle M, Kulkarni SK. Comparative brain cholinesterase-inhibiting activity of Glycyrrhiza glabra, Myristica fragrans, ascorbic acid, and metrifonate in mice. J Med Food. (2006)
- ^Ofir R, et al. Inhibition of serotonin re-uptake by licorice constituents. J Mol Neurosci. (2003)
- ^ ab Shang H, et al. Glabridin from Chinese herb licorice inhibits fatigue in mice. Afr J Tradit Complement Altern Med. (2009)
- ^ ab c Birari RB, et al. Antiobesity and lipid lowering effects of Glycyrrhiza chalcones: experimental and computational studies. Phytomedicine. (2011)
- ^García-Dorado D, Rodríguez-Sinovas A, Ruiz-Meana M. Gap junction-mediated spread of cell injury and death during myocardial ischemia-reperfusion. Cardiovasc Res. (2004)
- ^Rodríguez-Sinovas A, et al. Protective effect of gap junction uncouplers given during hypoxia against reoxygenation injury in isolated rat hearts. Am J Physiol Heart Circ Physiol. (2006)
- ^ ab Sigurjonsdottir HA, et al. Subjects with essential hypertension are more sensitive to the inhibition of 11 beta-HSD by liquorice. J Hum Hypertens. (2003)
- ^ ab c van Uum SH, et al. Effect of glycyrrhetinic acid on 11 beta-hydroxysteroid dehydrogenase activity in normotensive and hypertensive subjects. Clin Sci (Lond). (2002)
- ^van Uum SH, et al. Short-term cortisol infusion in the brachial artery, with and without inhibiting 11 beta-hydroxysteroid dehydrogenase, does not alter forearm vascular resistance in normotensive and hypertensive subjects. Eur J Clin Invest. (2002)
- ^ ab c Fuhrman B, et al. Licorice extract and its major polyphenol glabridin protect low-density lipoprotein against lipid peroxidation: in vitro and ex vivo studies in humans and in atherosclerotic apolipoprotein E-deficient mice. Am J Clin Nutr. (1997)
- ^Carmeli E, Fogelman Y. Antioxidant effect of polyphenolic glabridin on LDL oxidation. Toxicol Ind Health. (2009)
- ^ ab Belinky PA, et al. The antioxidative effects of the isoflavan glabridin on endogenous constituents of LDL during its oxidation. Atherosclerosis. (1998)
- ^ ab Belinky PA, et al. Structural aspects of the inhibitory effect of glabridin on LDL oxidation. Free Radic Biol Med. (1998)
- ^ ab c Rosenblat M, et al. Macrophage enrichment with the isoflavan glabridin inhibits NADPH oxidase-induced cell-mediated oxidation of low density lipoprotein. A possible role for protein kinase C. J Biol Chem. (1999)
- ^O’Brian CA, Ward NE, Vogel VG. Inhibition of protein kinase C by the 12-O-tetradecanoylphorbol-13-acetate antagonist glycyrrhetic acid. Cancer Lett. (1990)
- ^ ab c d e Kang JS, et al. Glabridin suppresses intercellular adhesion molecule-1 expression in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells by blocking sphingosine kinase pathway: implications of Akt, extracellular signal-regulated kinase, and nuclear factor-kappaB/Rel signaling pathways. Mol Pharmacol. (2006)
- ^Yoon G, et al. Inhibitory effect of chalcones and their derivatives from Glycyrrhiza inflata on protein tyrosine phosphatase 1B. Bioorg Med Chem Lett. (2009)
- ^Masding MG, et al. Premenopausal advantages in postprandial lipid metabolism are lost in women with type 2 diabetes. Diabetes Care. (2003)
- ^Masding MG, et al. The benefits of oestrogens on postprandial lipid metabolism are lost in post-menopausal women with Type 2 diabetes. Diabet Med. (2006)
- ^Somjen D, et al. High glucose blocks the effects of estradiol on human vascular cell growth: differential interaction with estradiol and raloxifene. J Steroid Biochem Mol Biol. (2004)
- ^Yehuda I, et al. Glabridin, a phytoestrogen from licorice root, up-regulates manganese superoxide dismutase, catalase and paraoxonase 2 under glucose stress. Phytother Res. (2011)
- ^Lee YS, et al. Aldose reductase inhibitory compounds from Glycyrrhiza uralensis. Biol Pharm Bull. (2010)
- ^Ahn J, et al. Anti-obesity effects of glabridin-rich supercritical carbon dioxide extract of licorice in high-fat-fed obese mice. Food Chem Toxicol. (2012)
- ^ ab Moon MH, et al. 18β-Glycyrrhetinic acid inhibits adipogenic differentiation and stimulates lipolysis. Biochem Biophys Res Commun. (2012)
- ^ ab c Mae T, et al. A licorice ethanolic extract with peroxisome proliferator-activated receptor-gamma ligand-binding activity affects diabetes in KK-Ay mice, abdominal obesity in diet-induced obese C57BL mice and hypertension in spontaneously hypertensive rats. J Nutr. (2003)
- ^Honda K, et al. The molecular mechanism underlying the reduction in abdominal fat accumulation by licorice flavonoid oil in high fat diet-induced obese rats. Anim Sci J. (2009)
- ^Kamisoyama H, et al. Investigation of the anti-obesity action of licorice flavonoid oil in diet-induced obese rats. Biosci Biotechnol Biochem. (2008)
- ^ ab Whitehouse MW, Dean PD, Halsall TG. Uncoupling of oxidative phosphorylation by glycyrrhetic acid, fusidic acid and some related triterpenoid acids. J Pharm Pharmacol. (1967)
- ^Biochemical properties of anti-inflammatory drugs—III.: Uncoupling of oxidative phosphorylation in a connective tissue (cartilage) and liver mitochondria by salicylate analogues: Relationship of structure to activity.
- ^ ab Tangri KK, et al. Biochemical study of anti-inflammatory and anti-arthritic properties of glycyrrhetic acid. Biochem Pharmacol. (1965)
- ^ ab c d Shi Q, et al. Glycyrrhetic acid synergistically enhances β₂-adrenergic receptor-Gs signaling by changing the location of Gαs in lipid rafts. PLoS One. (2012)
- ^Rybin VO, et al. Differential targeting of beta -adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem. (2000)
- ^Miura Y, Hanada K, Jones TL. G(s) signaling is intact after disruption of lipid rafts. Biochemistry. (2001)
- ^Tomlinson JW, et al. Inhibition of 11beta-hydroxysteroid dehydrogenase type 1 activity in vivo limits glucocorticoid exposure to human adipose tissue and decreases lipolysis. J Clin Endocrinol Metab. (2007)
- ^Sandeep TC, et al. Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone. Diabetes. (2005)
- ^Hardie DG, Ross FA, Hawley SA. AMP-Activated Protein Kinase: A Target for Drugs both Ancient and Modern. Chem Biol. (2012)
- ^ ab c d Armanini D, et al. Effect of licorice on the reduction of body fat mass in healthy subjects. J Endocrinol Invest. (2003)
- ^Aoki F, et al. Suppression by licorice flavonoids of abdominal fat accumulation and body weight gain in high-fat diet-induced obese C57BL/6J mice. Biosci Biotechnol Biochem. (2007)
- ^Nakagawa K, et al. Licorice flavonoids suppress abdominal fat accumulation and increase in blood glucose level in obese diabetic KK-A(y) mice. Biol Pharm Bull. (2004)
- ^ ab Licorice Flavonoid Oil Effects Body Weight Loss by Reduction of Body Fat Mass in Overweight Subjects.
- ^Armanini D, et al. Glycyrrhetinic acid, the active principle of licorice, can reduce the thickness of subcutaneous thigh fat through topical application. Steroids. (2005)
- ^ ab c Lim WY, et al. Lipoprotein lipase expression, serum lipid and tissue lipid deposition in orally-administered glycyrrhizic acid-treated rats. Lipids Health Dis. (2009)
- ^Enerbäck S, Gimble JM. Lipoprotein lipase gene expression: physiological regulators at the transcriptional and post-transcriptional level. Biochim Biophys Acta. (1993)
- ^ ab Eu CH, et al. Glycyrrhizic acid improved lipoprotein lipase expression, insulin sensitivity, serum lipid and lipid deposition in high-fat diet-induced obese rats. Lipids Health Dis. (2010)
- ^ ab c Kim YW, et al. Inhibition of LXRα-dependent steatosis and oxidative injury by liquiritigenin, a licorice flavonoid, as mediated with Nrf2 activation. Antioxid Redox Signal. (2011)
- ^S1P3-mediated Akt activation and crosstalk with plateletderived growth factor receptor (PDGFR).
- ^Tumor necrosis factor-α induces adhesion molecule expression through the sphingosine kinase pathway.
- ^Kwon HS, et al. Licochalcone A isolated from licorice suppresses lipopolysaccharide-stimulated inflammatory reactions in RAW264.7 cells and endotoxin shock in mice. J Mol Med (Berl). (2008)
- ^ ab Chu X, et al. Licochalcone a inhibits lipopolysaccharide-induced inflammatory response in vitro and in vivo. J Agric Food Chem. (2012)
- ^Funakoshi-Tago M, et al. Licochalcone A potently inhibits tumor necrosis factor alpha-induced nuclear factor-kappaB activation through the direct inhibition of IkappaB kinase complex activation. Mol Pharmacol. (2009)
- ^ ab Funakoshi-Tago M, et al. The fixed structure of Licochalcone A by alpha, beta-unsaturated ketone is necessary for anti-inflammatory activity through the inhibition of NF-kappaB activation. Int Immunopharmacol. (2010)
- ^ ab Furusawa J, et al. Glycyrrhiza inflata-derived chalcones, Licochalcone A, Licochalcone B and Licochalcone D, inhibit phosphorylation of NF-kappaB p65 in LPS signaling pathway. Int Immunopharmacol. (2009)
- ^Furusawa J, et al. Licochalcone A significantly suppresses LPS signaling pathway through the inhibition of NF-kappaB p65 phosphorylation at serine 276. Cell Signal. (2009)
- ^Funakoshi-Tago M, et al. Licochalcone A is a potent inhibitor of TEL-Jak2-mediated transformation through the specific inhibition of Stat3 activation. Biochem Pharmacol. (2008)
- ^ ab c Kim YW, et al. Anti-inflammatory effects of liquiritigenin as a consequence of the inhibition of NF-kappaB-dependent iNOS and proinflammatory cytokines production. Br J Pharmacol. (2008)
- ^Heyworth PG, Badwey JA. Continuous phosphorylation of both the 47 and the 49 kDa proteins occurs during superoxide production by neutrophils. Biochim Biophys Acta. (1990)
- ^Assembly of the neutrophil respiratory burst oxidase. Protein kinase C promotes cytoskeletal and membrane association of cytosolic oxidase components.
- ^Zwickey H, et al. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD25 expression in humans: a pilot study. Phytother Res. (2007)
- ^Brush J, et al. The effect of Echinacea purpurea, Astragalus membranaceus and Glycyrrhiza glabra on CD69 expression and immune cell activation in humans. Phytother Res. (2006)
- ^ ab Yang N, et al. Glycyrrhiza uralensis Flavonoids Present in Anti-Asthma Formula, ASHMI(TM) , Inhibit Memory Th2 Responses in Vitro and in Vivo. Phytother Res. (2012)
- ^ ab Wen MC, et al. Efficacy and tolerability of anti-asthma herbal medicine intervention in adult patients with moderate-severe allergic asthma. J Allergy Clin Immunol. (2005)
- ^Kim YH, et al. Antiangiogenic effect of licochalcone A. Biochem Pharmacol. (2010)
- ^Xie SR, et al. Liquiritigenin inhibits serum-induced HIF-1α and VEGF expression via the AKT/mTOR-p70S6K signalling pathway in HeLa cells. Phytother Res. (2012)
- ^Liu Y, et al. Liquiritigenin inhibits tumor growth and vascularization in a mouse model of HeLa cells. Molecules. (2012)
- ^Jackson KM, Frazier MC, Harris WB. Suppression of androgen receptor expression by dibenzoylmethane as a therapeutic objective in advanced prostate cancer. Anticancer Res. (2007)
- ^Hundertmark S, et al. Inhibition of 11 beta-hydroxysteroid dehydrogenase activity enhances the antiproliferative effect of glucocorticosteroids on MCF-7 and ZR-75-1 breast cancer cells. J Endocrinol. (1997)
- ^ ab Koyama K, et al. Expression of the 11beta-hydroxysteroid dehydrogenase type II enzyme in breast tumors and modulation of activity and cell growth in PMC42 cells. J Steroid Biochem Mol Biol. (2001)
- ^Zhao K, et al. Inhibition of gap junction channel attenuates the migration of breast cancer cells. Mol Biol Rep. (2012)
- ^Rossi T, et al. Selectivity of action of glycyrrhizin derivatives on the growth of MCF-7 and HEP-2 cells. Anticancer Res. (2003)
- ^Weng SC, et al. Sensitizing estrogen receptor-negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor. Mol Cancer Ther. (2008)
- ^ ab Sharma G, et al. 18β-glycyrrhetinic acid induces apoptosis through modulation of Akt/FOXO3a/Bim pathway in human breast cancer MCF-7 cells. J Cell Physiol. (2012)
- ^Shimoyama Y, et al. Effects of glycyrrhetinic acid derivatives on hepatic and renal 11beta-hydroxysteroid dehydrogenase activities in rats. J Pharm Pharmacol. (2003)
- ^Walker BR, Edwards CR. Licorice-induced hypertension and syndromes of apparent mineralocorticoid excess. Endocrinol Metab Clin North Am. (1994)
- ^Farese RV Jr, et al. Licorice-induced hypermineralocorticoidism. N Engl J Med. (1991)
- ^ ab Josephs RA, et al. Liquorice consumption and salivary testosterone concentrations. Lancet. (2001)
- ^Heilmann P, et al. Administration of glycyrrhetinic acid: significant correlation between serum levels and the cortisol/cortisone-ratio in serum and urine. Exp Clin Endocrinol Diabetes. (1999)
- ^ ab Armanini D, et al. Further studies on the mechanism of the mineralocorticoid action of licorice in humans. J Endocrinol Invest. (1996)
- ^ ab Krähenbühl S, et al. Kinetics and dynamics of orally administered 18 beta-glycyrrhetinic acid in humans. J Clin Endocrinol Metab. (1994)
- ^ ab MacKenzie MA, et al. The influence of glycyrrhetinic acid on plasma cortisol and cortisone in healthy young volunteers. J Clin Endocrinol Metab. (1990)
- ^ ab c d e Al-Dujaili EA, et al. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity. Mol Cell Endocrinol. (2011)
- ^Takeda R, et al. Glycyrrhizic acid and its hydrolysate as mineralocorticoid agonist. J Steroid Biochem. (1987)
- ^Armanini D, Karbowiak I, Funder JW. Affinity of liquorice derivatives for mineralocorticoid and glucocorticoid receptors. Clin Endocrinol (Oxf). (1983)
- ^Kroes BH, et al. Inhibition of human complement by beta-glycyrrhetinic acid. Immunology. (1997)
- ^ ab Armanini D, et al. Licorice reduces serum testosterone in healthy women. Steroids. (2004)
- ^ ab Krazeisen A, et al. Phytoestrogens inhibit human 17beta-hydroxysteroid dehydrogenase type 5. Mol Cell Endocrinol. (2001)
- ^ ab Armanini D, Bonanni G, Palermo M. Reduction of serum testosterone in men by licorice. N Engl J Med. (1999)
- ^Armanini D, et al. Licorice consumption and serum testosterone in healthy man. Exp Clin Endocrinol Diabetes. (2003)
- ^ ab Shin S, et al. Licorice extract does not impair the male reproductive function of rats. Exp Anim. (2008)
- ^ ab c d Sigurjonsdottir HA, et al. Liquorice in moderate doses does not affect sex steroid hormones of biological importance although the effect differs between the genders. Horm Res. (2006)
- ^Takeuchi T, et al. Effect of paeoniflorin, glycyrrhizin and glycyrrhetic acid on ovarian androgen production. Am J Chin Med. (1991)
- ^Takahashi K, et al. Effect of a traditional herbal medicine (shakuyaku-kanzo-to) on testosterone secretion in patients with polycystic ovary syndrome detected by ultrasound. Nihon Sanka Fujinka Gakkai Zasshi. (1988)
- ^ ab c d e Mattarello MJ, et al. Effect of licorice on PTH levels in healthy women. Steroids. (2006)
- ^ ab c Tamaya T, Sato S, Okada H. Inhibition by plant herb extracts of steroid bindings in uterus, liver and serum of the rabbit. Acta Obstet Gynecol Scand. (1986)
- ^ ab c Zamansoltani F, et al. Antiandrogenic activities of Glycyrrhiza glabra in male rats. Int J Androl. (2009)
- ^Fukai T, et al. Anti-Helicobacter pylori flavonoids from licorice extract. Life Sci. (2002)
- ^Hatano T, et al. Phenolic constituents of licorice. VIII. Structures of glicophenone and glicoisoflavanone, and effects of licorice phenolics on methicillin-resistant Staphylococcus aureus. Chem Pharm Bull (Tokyo). (2000)
- ^Immunoprecipitation coupled with HPLC–MS/MS to discover the aromatase ligands from Glycyrrhiza uralensis.
- ^ ab Ye L, et al. Dietary administration of the licorice flavonoid isoliquiritigenin deters the growth of MCF-7 cells overexpressing aromatase. Int J Cancer. (2009)
- ^ ab Detection of estrogenic activity in herbal teas by in vitro reporter assays.
- ^Tamir S, et al. Estrogen-like activity of glabrene and other constituents isolated from licorice root. J Steroid Biochem Mol Biol. (2001)
- ^ ab Tamir S, et al. Estrogenic and antiproliferative properties of glabridin from licorice in human breast cancer cells. Cancer Res. (2000)
- ^Somjen D, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. (2004)
- ^Somjen D, et al. Estrogen-like activity of licorice root constituents: glabridin and glabrene, in vascular tissues in vitro and in vivo. J Steroid Biochem Mol Biol. (2004)
- ^ ab c d Simons R, et al. Agonistic and antagonistic estrogens in licorice root (Glycyrrhiza glabra). Anal Bioanal Chem. (2011)
- ^ ab Mersereau JE, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol. (2008)
- ^Sotoca AM, et al. Superinduction of estrogen receptor mediated gene expression in luciferase based reporter gene assays is mediated by a post-transcriptional mechanism. J Steroid Biochem Mol Biol. (2010)
- ^Kim IG, et al. Screening of estrogenic and antiestrogenic activities from medicinal plants. Environ Toxicol Pharmacol. (2008)
- ^Hillerns PI, et al. Binding of phytoestrogens to rat uterine estrogen receptors and human sex hormone-binding globulins. Z Naturforsch C. (2005)
- ^Martin MD, et al. A controlled trial of a dissolving oral patch concerning glycyrrhiza (licorice) herbal extract for the treatment of aphthous ulcers. Gen Dent. (2008)
- ^Tang J, et al. Effects of ephedra water decoction and cough tablets containing ephedra and liquorice on CYP1A2 and the pharmacokinetics of theophylline in rats. Phytother Res. (2012)
- ^Busse PJ, et al. The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice. Ann Allergy Asthma Immunol. (2010)
- ^Zhang T, et al. Pharmacology and immunological actions of a herbal medicine ASHMI on allergic asthma. Phytother Res. (2010)
- ^ ab Lee KH, et al. Xia-bai-san inhibits lipopolysaccharide-induced activation of intercellular adhesion molecule-1 and nuclear factor-kappa B in human lung cells. J Ethnopharmacol. (2009)
- ^Sakr S, Shalaby SY. Carbendazim-induced testicular damage and oxidative stress in albino rats: Ameliorative effect of licorice aqueous extract. Toxicol Ind Health. (2012)
- ^ ab Malekinejad H, et al. Protective effects of melatonin and Glycyrrhiza glabra extract on ochratoxin A--induced damages on testes in mature rats. Hum Exp Toxicol. (2011)
- ^Yahagi N, et al. Absence of sterol regulatory element-binding protein-1 (SREBP-1) ameliorates fatty livers but not obesity or insulin resistance in Lep(ob)/Lep(ob) mice. J Biol Chem. (2002)
- ^Kim YM, et al. Inhibition of liver X receptor-α-dependent hepatic steatosis by isoliquiritigenin, a licorice antioxidant flavonoid, as mediated by JNK1 inhibition. Free Radic Biol Med. (2010)
- ^Rhee SD, et al. Carbenoxolone prevents the development of fatty liver in C57BL/6-Lep ob/ob mice via the inhibition of sterol regulatory element binding protein-1c activity and apoptosis. Eur J Pharmacol. (2012)
- ^Alberts P, et al. Selective inhibition of 11beta-hydroxysteroid dehydrogenase type 1 decreases blood glucose concentrations in hyperglycaemic mice. Diabetologia. (2002)
- ^Park JS, et al. Anti-diabetic and anti-adipogenic effects of a novel selective 11β-hydroxysteroid dehydrogenase type 1 inhibitor, 2-(3-benzoyl)-4-hydroxy-1,1-dioxo-2H-1,2-benzothiazine-2-yl-1-phenylethanone (KR-66344). Biochem Pharmacol. (2011)
- ^Daniel EE. Communication between interstitial cells of Cajal and gastrointestinal muscle. Neurogastroenterol Motil. (2004)
- ^Takeda Y, et al. Effects of the gap junction blocker glycyrrhetinic acid on gastrointestinal smooth muscle cells. Am J Physiol Gastrointest Liver Physiol. (2005)
- ^Glycyrrhetinic acid derivatives: a novel class of inhibitors of gap-junctional intercellular communication. Structure-activity relationships.
- ^Davidson JS, Baumgarten IM, Harley EH. Reversible inhibition of intercellular junctional communication by glycyrrhetinic acid. Biochem Biophys Res Commun. (1986)
- ^Sato Y, et al. Glycycoumarin from Glycyrrhizae Radix acts as a potent antispasmodic through inhibition of phosphodiesterase 3. J Ethnopharmacol. (2006)
- ^Nagai H, et al. Antispasmodic activity of licochalcone A, a species-specific ingredient of Glycyrrhiza inflata roots. J Pharm Pharmacol. (2007)
- ^ ab c Yokota T, et al. The inhibitory effect of glabridin from licorice extracts on melanogenesis and inflammation. Pigment Cell Res. (1998)
- ^Kelly-Pieper K, et al. Safety and tolerability of an antiasthma herbal Formula (ASHMI) in adult subjects with asthma: a randomized, double-blinded, placebo-controlled, dose-escalation phase I study. J Altern Complement Med. (2009)
- ^ ab Fuhrman B, et al. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid Redox Signal. (2000)
- ^Effects of traditional medicines, Gosya-jinki-gan, “Kyushin” and “Reiousan” on sexual and learning behaviour in chronically stressed mice.
- ^Saruta J, et al. Expression and localization of chromogranin A gene and protein in human submandibular gland. Cells Tissues Organs. (2005)
- ^Nakane H, et al. Effect of negative air ions on computer operation, anxiety and salivary chromogranin A-like immunoreactivity. Int J Psychophysiol. (2002)
- ^ ab Feldman M, Grenier D. Cranberry proanthocyanidins act in synergy with licochalcone A to reduce Porphyromonas gingivalis growth and virulence properties, and to suppress cytokine secretion by macrophages. J Appl Microbiol. (2012)
- ^Nakagawa K, et al. 90-Day repeated-dose toxicity study of licorice flavonoid oil (LFO) in rats. Food Chem Toxicol. (2008)
- ^Armanini D, et al. History of the endocrine effects of licorice. Exp Clin Endocrinol Diabetes. (2002)
- ^Ohtake N, et al. A possible involvement of 3-monoglucuronyl-glycyrrhetinic acid, a metabolite of glycyrrhizin (GL), in GL-induced pseudoaldosteronism. Life Sci. (2007)
- ^Makino T, et al. 3-Monoglucuronyl-glycyrrhretinic acid is a substrate of organic anion transporters expressed in tubular epithelial cells and plays important roles in licorice-induced pseudoaldosteronism by inhibiting 11β-hydroxysteroid dehydrogenase 2. J Pharmacol Exp Ther. (2012)
- ^Caradonna P, et al. Acute myopathy associated with chronic licorice ingestion: reversible loss of myoadenylate deaminase activity. Ultrastruct Pathol. (1992)
- ^Barrella M, et al. Hypokaliemic rhabdomyolysis associated with liquorice ingestion: report of an atypical case. Ital J Neurol Sci. (1997)