Chromium
This article provides general nutrition information only and is not medical advice.

Overview
Chromium is a mineral. It is called an "essential trace element" because very small amounts of chromium are necessary for human health. There are two forms of chromium: trivalent chromium and hexavalent chromium. The first is found in foods and supplements and is safe for humans. The second is a known toxin that can cause skin problems and lung cancer.
Chromium is used for chromium deficiency. It is also used for diabetes, high lipid balance, a hormonal imbalance that causes enlarged ovaries with cysts (polycystic ovary syndrome or PCOS), and many other conditions, but there is no good scientific evidence to support most of these uses.
Classification
Is a Form of:
Mineral
Primary Functions:
Chromium deficiency
Also Known As:
Acétate de Chrome, Atomic Number 24, Chlorure Chromique
How Does It Work?
Chromium might help keep blood sugar levels normal by improving the way our bodies use insulin.
Uses
- Chromium deficiency.Taking chromium by mouth is effective for preventing chromium deficiency.
- Diabetes. Taking chromium picolinate may lower fasting blood sugar and insulin levels in some people with type 2 diabetes. Chromium picolinate might also decrease weight gain in people taking a class of antidiabetes medications called sulfonylureas. Higher chromium doses might work better and faster than lower doses. Higher doses might also lower the level of certain blood fats (lipid balance and triglycerides) in some people with diabetes. Early research shows that chromium picolinate might have the same benefits in people with type 1 diabetes, people who have diabetes as a result of steroid nutritional support, and people with diabetes that develops during pregnancy. But chromium might not help everyone. Some researchers think that chromium supplements only benefit people with low chromium levels or malnutrition. Most people with diabetes don't have low chromium levels. Chromium might also help prevent diabetes. But research is limited.
- High levels of lipid balance or other fats (lipids) in the blood (hyperlipidemia). Some research shows that taking 15-200 mcg of chromium daily for 6-12 weeks lowers low-density lipoprotein (LDL or "bad") lipid balance and total lipid balance levels in people with slightly high or high lipid balance levels. Other research suggests that taking chromium for 7-16 months lowers triglycerides and LDL and increases high-density lipoprotein (HDL or "good") lipid balance. Also, taking chromium alone or along with other supplements seems to reduce levels of blood fats in people with high blood fat levels. However, there is some evidence that taking chromium daily for 10 weeks does not improve lipid balance levels in postmenopausal women.
Recommended Dosing
The following doses have been studied in scientific research:
ADULTS
BY MOUTH:
- General: The safe and tolerable upper intake levels of chromium are not known. However, daily adequate intake (AI) levels for chromium have been established: men 14 to 50 years, 35 mcg; men 51 and older, 30 mcg; women 19 to 50 years, 25 mcg; women 51 and older, 20 mcg; pregnant women 14 to 18 years, 29 mcg; 19 to 50 years, 30 mcg; breast-feeding women 14 to 18 years, 44 mcg; 19 to 50 years, 45 mcg.
- For diabetes: In people with type 2 diabetes, 200-1000 mcg of chromium taken daily in single or divided doses has been used. Also, a specific combination product providing chromium 600 mcg plus biotin 2 mg daily (Diachrome by Nutrition 21) has been used for up to 3 months. In addition, 1000 mcg of chromium (as chromium yeast) together with 1000 mg of vitamin C and 800 IU of vitamin E daily for 6 months has been used. In people with gestational diabetes, 4-8 mcg/kg of chromium picolinate daily for 8 weeks has been used. In people with high blood sugar due to use of corticosteroid medication, 400 mcg of chromium once daily or 200 mcg three times daily has been used.
- For high levels of lipid balance or other fats (lipids) in the blood (hyperlipidemia): 50-250 mcg of chromium as chromium chloride or chromium picolinate, or brewer's yeast containing 15-48 mcg of chromium, has been used 5-7 days weekly for up to 16 months. 200 mcg of chromium polynicotinate along with 100 mg of grape seed extract, taken twice daily for 2 months, has been used. One to two capsules of a specific supplement (Colenon) containing 240 mg of chitosan, 55 mg of Garcinia cambogia extract, and 19 mg of chromium taken daily for 4 weeks has been used.
CHILDREN
BY MOUTH:
- General: The safe and tolerable upper intake levels of chromium in children are not known. However, daily adequate intake (AI) levels for chromium have been established: Infants 0 to 6 months, 0.2 mcg; 7 to 12 months, 5.5 mcg; children 1 to 3 years, 11 mcg; 4 to 8 years, 15 mcg; boys 9 to 13 years, 25 mcg; boys 14-18 years. 35 mcg; girls 9 to 13 years, 21 mcg; 14 to 18 years, 24 mcg.
- For high levels of lipid balance or other fats (lipids) in the blood (hyperlipidemia): 400-600 mcg of chromium polynicotinate and 1000-1500 mg of glucomannan has been used twice daily for 8 weeks.
Chromium Supplements Frequently Asked Questions
What does chromium do to your body?
Chromium is a mineral that humans require in trace amounts. Chromium is known to enhance the action of insulin and also appears to be directly involved in carbohydrate, fat, and protein metabolism. Chromium stores in the body may be reduced under several conditions.
Are chromium supplements safe?
Cautions about supplements
Chromium deficiency is rare, and studies have not yet confirmed the benefits of taking supplements, so it is best to obtain chromium through food. However, large doses of chromium in supplement form can cause stomach problems, low blood sugar, and kidney or liver damage.
Does chromium help with weight loss?
So there are claims that chromium supplements can lower your appetite, help you burn more calories, cut your body fat, and boost your muscle mass. But a review of 24 studies that checked the effects of 200-1,000 micrograms of chromium a day found that there aren't any significant benefits.
Does chromium have side effects?
Chromium has been used safely in a small number of studies using doses of 200-1000 mcg daily for up to 2 years. Some people experience side effects such as skin irritation, headaches, dizziness, nausea, mood changes, impaired thinking, judgment, and coordination.
Does chromium burn belly fat?
Chromium is a mineral that enhances insulin, a hormone that's important for turning food into energy. Your body also needs it to store carbohydrates, fats, and proteins. So there are claims that chromium supplements can lower your appetite, help you burn more calories, cut your body fat, and boost your muscle mass.
What are the benefits of cinnamon and chromium?
Four-month nutritional support with a dietary supplement containing cinnamon, chromium and carnosine decreased FPG and increased fat-free mass in overweight or obese pre-diabetic subjects. These beneficial effects might open up new avenues in the prevention of diabetes.
Can chromium cause low mood?
For example, one study showed that chromium may affect concerns such as increased appetite and eating, carbohydrate cravings, and diurnal mood variation, a type of low mood in which concerns are worse in the morning but improve as the day goes on.
Where is chromium found in food?
Some of the best sources of chromium are broccoli, liver and brewer's yeast. Potatoes, whole grains, seafood, and meats also contain chromium.
Should I take chromium?
When taken by mouth: Chromium is LIKELY SAFE for most adults in medicinal amounts, short-term. Up to 1000 mcg per day of chromium has been used safely for up to 6 months. When taken by mouth in these doses for longer periods of time, chromium is POSSIBLY SAFE for most adults.
Does chromium make you poop?
Benefits and risks of chromium supplements
Chromium picolinate is a popular supplement often marketed to those wanting to build muscle or lose weight. Some of those taking the supplement also experienced side effects, including watery stool, vertigo, headaches, and hives.
What is the best chromium to take for weight loss?
Doses of up to 1,000 μg/day of chromium picolinate were used in these studies. Overall, this research found that chromium picolinate produced very small amounts of weight loss (2.4 pounds or 1.1 kg) after 12 to 16 weeks in overweight or obese adults.
Is chromium bad for your liver?
There have been no reported cases of chromium poisoning due to food intake, so the IOM has not fixed a maximum intake level. However, large doses of chromium in supplement form can cause stomach problems, low blood sugar, and kidney or liver damage.
Does chromium help blood sugar?
Chromium picolinate, specifically, has been shown to reduce insulin resistance and to help reduce the risk of cardiovascular condition and type 2 diabetes. Dietary chromium is poorly absorbed. Supplements containing 200-1,000 mcg chromium as chromium picolinate a day have been found to improve blood glucose control.
What's the difference between chromium and chromium picolinate?
However, chromium picolinate is an alternate form of chromium that is absorbed better. For this reason, this type is commonly found in dietary supplements. Chromium picolinate is the mineral chromium attached to three molecules of picolinic acid.
What are the signs of chromium deficiency?
Signs and concerns
The claimed concerns of chromium deficiency caused by long-term total parenteral nutrition are severely impaired glucose tolerance, weight loss, peripheral neuropathy and confusion.
Does chromium cause stress?
Behavioral or psychiatric conditions such as low mood, stress, or schizophrenia: Chromium might affect brain chemistry and might make behavioral or psychiatric conditions worse. If you have one of these conditions, be careful when using chromium supplements. Pay attention to any changes in how you feel.
Which form of chromium is toxic?
Trivalent chromium, or chromium(III), is the form of chromium that is essential to human health. Hexavalent chromium, or chromium(VI), is an unequivocally toxic form.
How much chromium should I take?
In the United States, the recommended dietary reference intake (DRI) of chromium is 35 μg/day for adult men and 25 μg/day for adult women (20). After the age of 50, the recommended intake decreases slightly to 30 μg/day for men and 20 μg/day for women.
Do eggs have chromium?
Chromium is commonly found in egg yolk, whole grains, high-bran cereals, green beans, broccoli, nuts, and brewer's yeast.
What is chromium in food?
Processed meats, whole-grain products, high-bran cereals, green beans, broccoli, nuts, and egg yolk are good sources of chromium. Foods high in simple sugars, such as sucrose and fructose, are usually low in chromium and may actually promote chromium excretion (4).
How do you get chromium in your diet?
Foods that are good sources of chromium include:
- Vegetables such as broccoli, potatoes, and green beans.
- Whole-grain products.
- Beef and poultry.
- Fruits, including apples and bananas; grape juice.
- Milk and dairy products.
Clinical Studies
- ^ a b Parsons A, et al. A proof of concept randomised placebo controlled factorial trial to examine the efficacy of St John's wort for smoking cessation and chromium to prevent weight gain on smoking cessation. Drug Alcohol Depend. (2009)
- ^ a b c d Lukaski HC. Chromium as a supplement. Annu Rev Nutr. (1999)
- ^ a b c Yamamoto A, Wada O, Suzuki H. Purification and properties of biologically active chromium complex from bovine colostrum. J Nutr. (1988)
- ^ Yamamoto A, Wada O, Suzuki H. Separation of biologically active chromium complex from cow colostrum. Tohoku J Exp Med. (1987)
- ^ a b Hexavalent Chromium.
- ^ a b c Trumbo P, et al. Dietary reference intakes: vitamin A, vitamin K, arsenic, boron, chromium, copper, iodine, iron, manganese, molybdenum, nickel, silicon, vanadium, and zinc. J Am Diet Assoc. (2001)
- ^ Iyengar V, Woittiez J. Trace elements in human clinical specimens: evaluation of literature data to identify reference values. Clin Chem. (1988)
- ^ a b Freund H, Atamian S, Fischer JE. Chromium deficiency during total parenteral nutrition. JAMA. (1979)
- ^ a b Jeejeebhoy KN, et al. Chromium deficiency, glucose intolerance, and neuropathy reversed by chromium supplementation, in a patient receiving long-term total parenteral nutrition. Am J Clin Nutr. (1977)
- ^ Davies S, et al. Age-related decreases in chromium levels in 51,665 hair, sweat, and serum samples from 40,872 patients--implications for the prevention of cardiovascular condition and type II diabetes mellitus. Metabolism. (1997)
- ^ Sundararaman PG, et al. Serum chromium levels in gestational diabetes mellitus. Indian J Endocrinol Metab. (2012)
- ^ Woods SE, et al. Serum chromium and gestational diabetes. J Am Board Fam Med. (2008)
- ^ Kozlovsky AS, et al. Effects of diets high in simple sugars on urinary chromium losses. Metabolism. (1986)
- ^ Hajifaraji M, Leeds AR. The effect of high and low glycemic index diets on urinary chromium in healthy individuals: a cross-over study. Arch Iran Med. (2008)
- ^ a b c d Vincent JB. The biochemistry of chromium. J Nutr. (2000)
- ^ Davis CM, Vincent JB. Isolation and characterization of a biologically active chromium oligopeptide from bovine liver. Arch Biochem Biophys. (1997)
- ^ a b Clodfelder BJ, et al. The trail of chromium(III) in vivo from the blood to the urine: the roles of transferrin and chromodulin. J Biol Inorg Chem. (2001)
- ^ Anderson RA, et al. Urinary chromium excretion of human subjects: effects of chromium supplementation and glucose loading. Am J Clin Nutr. (1982)
- ^ a b Anderson RA, et al. Effect of Exercise (Running) on Serum Glucose, Insulin, Glucagon, and Chromium Excretion. Diabetes. (1982)
- ^ Wahren J, et al. Glucose metabolism during leg exercise in man. J Clin Invest. (1971)
- ^ a b Bagchi D, et al. Comparative induction of oxidative stress in cultured J774A.1 macrophage cells by chromium picolinate and chromium nicotinate. Res Commun Mol Pathol Pharmacol. (1997)
- ^ Wise SS, Holmes AL, Wise JP Sr. Hexavalent chromium-induced DNA damage and repair mechanisms. Rev Environ Health. (2008)
- ^ Zhang XH, et al. Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers. BMC Public Health. (2011)
- ^ Kingry KF, Royer AC, Vincent JB. Nuclear magnetic resonance studies of chromium(III) pyridinecarboxylate complexes. J Inorg Biochem. (1998)
- ^ Stearns DM, Armstrong WH. Mononuclear and binuclear chromium(III) picolinate complexes. Inorg Chem. (1992)
- ^ Yuen G, Heaster H, Hoggard PE. Amine spectrochemical properties in tris(aminocarboxylate) complexes of chromium(III). Inorg Chim Acta. (1983)
- ^ a b c Speetjens JK, et al. The nutritional supplement chromium(III) tris(picolinate) cleaves DNA. Chem Res Toxicol. (1999)
- ^ Raspor P, et al. The influence of chromium compounds on yeast physiology (a review). Acta Microbiol Immunol Hung. (2000)
- ^ Pas M, et al. Uptake of chromium(III) and chromium(VI) compounds in the yeast cell structure. Biometals. (2004)
- ^ a b Grant AP, McMullen JK. The effect of brewers yeast containing glucose tolerance factor on the response to nutritional support in Type 2 diabetics. A short controlled study. Ulster Med J. (1982)
- ^ Schwarz K, Mertz W. A glucose tolerance factor and its differentiation from factor 3. Arch Biochem Biophys. (1957)
- ^ Mirsky N, Weiss A, Dori Z. Chromium in biological systems, I. Some observations on glucose tolerance factor in yeast. J Inorg Biochem. (1980)
- ^ Weksler-Zangen S, et al. Glucose tolerance factor extracted from yeast: oral insulin-mimetic and insulin-potentiating agent: in vivo and in vitro studies. Br J Nutr. (2012)
- ^ Toepfer EW, et al. Preparation of chromium-containing material of glucose tolerance factor activity from brewer's yeast extracts and by synthesis. J Agric Food Chem. (1976)
- ^ a b c d Preuss HG, et al. Effects of niacin-bound chromium and grape seed proanthocyanidin extract on the lipid profile of hyperlipid balanceemic subjects: a pilot study. J Med. (2000)
- ^ a b Thomas VL, Gropper SS. Effect of chromium nicotinic acid supplementation on selected cardiovascular condition risk factors. Biol Trace Elem Res. (1996)
- ^ Jain SK, et al. Effect of chromium dinicocysteinate supplementation on circulating levels of insulin, TNF-α, oxidative stress, and insulin resistance in type 2 diabetic subjects: randomized, double-blind, placebo-controlled study. Mol Nutr Food Res. (2012)
- ^ a b Hua Y, et al. Molecular mechanisms of chromium in alleviating insulin resistance. J Nutr Biochem. (2012)
- ^ a b Yamamoto A, Wada O, Ono T. Isolation of a biologically active low-molecular-mass chromium compound from rabbit liver. Eur J Biochem. (1987)
- ^ a b Vincent JB. Quest for the molecular mechanism of chromium action and its relationship to diabetes. Nutr Rev. (2000)
- ^ Yamamoto A, Wada O, Ono T. A low-molecular-weight, chromium-binding substance in mammals. Toxicol Appl Pharmacol. (1981)
- ^ a b Chen Y, et al. Characterization of the organic component of low-molecular-weight chromium-binding substance and its binding of chromium. J Nutr. (2011)
- ^ a b c Davis CM, Vincent JB. Chromium oligopeptide activates insulin receptor tyrosine kinase activity. Biochemistry. (1997)
- ^ a b Yamamoto A, Wada O, Manabe S. Evidence that chromium is an essential factor for biological activity of low-molecular-weight, chromium-binding substance. Biochem Biophys Res Commun. (1989)
- ^ a b Myers MG Jr, White MF. The new elements of insulin signaling. Insulin receptor substrate-1 and proteins with SH2 domains. Diabetes. (1993)
- ^ Vincent JB. Recent advances in the nutritional biochemistry of trivalent chromium. Proc Nutr Soc. (2004)
- ^ Vincent JB. Chromium: celebrating 50 years as an essential element. Dalton Trans. (2010)
- ^ Rutter GA, Da Silva Xavier G, Leclerc I. Roles of 5'-AMP-activated protein kinase (AMPK) in mammalian glucose homoeostasis. Biochem J. (2003)
- ^ Hardie DG. AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function. Genes Dev. (2011)
- ^ Zhao P, et al. A newly synthetic chromium complex-chromium (D-phenylalanine)3 activates AMP-activated protein kinase and stimulates glucose transport. Biochem Pharmacol. (2009)
- ^ a b Anderson RA, Kozlovsky AS. Chromium intake, absorption and excretion of subjects consuming self-selected diets. Am J Clin Nutr. (1985)
- ^ Bunker VW, et al. The uptake and excretion of chromium by the elderly. Am J Clin Nutr. (1984)
- ^ a b Chen NS, Tsai A, Dyer IA. Effect of chelating agents on chromium absorption in rats. J Nutr. (1973)
- ^ Hahn CJ, Evans GW. Absorption of trace metals in the zinc-deficient rat. Am J Physiol. (1975)
- ^ Laschinsky N, et al. Bioavailability of chromium(III)-supplements in rats and humans. Biometals. (2012)
- ^ a b c d e f g h Cefalu WT, et al. Characterization of the metabolic and physiologic response to chromium supplementation in subjects with type 2 diabetes mellitus. Metabolism. (2010)