Vitamin E

October 3, 2020

Overview

Vitamin E is a vitamin that dissolves in fat. It is found in many foods including vegetable oils, cereals, meat, poultry, eggs, fruits, vegetables, and wheat germ oil. It is also available as a supplement.

Vitamin E is used for treating vitamin E deficiency, which is rare, but can occur in people with certain genetic disorders and in very low-weight premature infants. Vitamin E is also used for many other conditions, but there is no good scientific evidence to support these other uses.

The American Heart Association recommends obtaining antioxidants, including vitamin E, by eating a well-balanced diet high in fruits, vegetables, and whole grains rather than from supplements until more is known about the risks and benefits of taking supplements.

A type of vitamin E called vitamin E acetate is an ingredient in some vaping products. Using vaping products containing vitamin E acetate has been linked to serious lung injury.

Classification

Is a Form of:

Vitamin

Primary Functions:

Vitamin E deficiency

Also Known As:

Acétate d'Alpha Tocophérol, Acétate d'Alpha Tocophéryl

How Does It Work?

Vitamin E is an important vitamin required for the proper function of many organs in the body. It is also an antioxidant. This means it helps to slow down processes that damage cells.

Uses

An inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED). The genetic movement disorder called ataxia causes severe vitamin E deficiency. Vitamin E supplements are used as part of the treatment for ataxia.
Vitamin E deficiency. Taking vitamin E by mouth is effective for preventing and treating vitamin E deficiency.
Alzheimer disease. Some early research suggests that dietary intake of vitamin E is linked to a lower chance of developing Alzheimer disease. But not all research agrees. Taking vitamin E supplements doesn't seem to prevent Alzheimer disease from developing. In people who already have Alzheimer disease, taking vitamin E along with some anti-Alzheimer medicines might slow down the worsening of memory loss. Vitamin E might also delay the loss of independence and the need for caregiver assistance in people with mild-to-moderate Alzheimer disease.
Low levels of red blood cells in people with long-term illness (anemia of chronic disease). Some research shows that that taking vitamin E improves the response to the drug erythropoietin, which affects red blood cell production, in adults and children on hemodialysis.
A blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia). Taking vitamin E by mouth seems to benefit children with the blood disorder called beta-thalassemia and vitamin E deficiency.
Leakage of intravenous (IV) drug from the vein into the surrounding skin and tissue (extravasation). Applying vitamin E to the skin together with dimethylsulfoxide (DMSO) seems to be effective for treating leakage of chemotherapy into surrounding tissues.
Menstrual cramps (dysmenorrhea). Taking vitamin E for 2 days before bleeding and for 3 days after bleeding starts seems to decrease pain and reduce menstrual blood loss. Taking vitamin E with fish oil might provide even more pain relief than taking vitamin E alone.
Scarring or hardening of blood vessels in the kidney (glomerulosclerosis). There is some evidence that taking vitamin E by mouth might improve kidney function in children with glomerulosclerosis.
An inherited disorder that causes red blood cells to break down in response to stress (G6PD deficiency). Some research shows that taking vitamin E by mouth, alone or together with selenium, might benefit people with an inherited disorder called G6PD deficiency.
A type of non-cancerous skin sore (granuloma annulare). Applying vitamin E to the skin seems to clear up skin sores called granuloma annulare.
An inherited brain disorder that affects movements, emotions, and thinking (Huntington disease). Natural vitamin E (RRR-alpha-tocopherol) can improve symptoms in people with early Huntington disease. However, it doesn't seem to help people with more advanced disease.
Bleeding within the skull (intracranial hemorrhage). Taking vitamin E by mouth seems to be effective for treating bleeding in the skull in premature infants.
Bleeding into or around the fluid-filled areas (ventricles) of the brain (intraventricular hemorrhage). Some research shows that giving vitamin E by mouth to premature infants can reduce the risk for bleeding into the brain. But giving high doses of vitamin E might increase the risk for a serious blood infection (sepsis) in these infants.
Conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility). Taking vitamin E by mouth improves pregnancy rates for men with fertility problems. But taking high doses of vitamin E together with vitamin C doesn't seem to provide the same benefits.
Reduced benefit of nitrate therapy that happens when nitrates are used all day (nitrate tolerance). There is some evidence that taking vitamin E daily can help prevent nitrate tolerance.
Swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (nonalcoholic steatohepatitis or NASH). Taking vitamin E daily seems to improve inflammation and liver markers of this form of liver disease in adults and children.
Parkinson disease. People who get more vitamin E in their diet might have a lower risk of Parkinson disease. Taking supplements containing vitamin E doesn't seem to benefit people already diagnosed with Parkinson disease.
Recovery from laser eye surgery (photoreactive keratectomy). Taking high doses of vitamin A along with vitamin E (alpha-tocopheryl nicotinate) daily seems to improve healing and vision in people undergoing laser eye surgery.
Premenstrual syndrome (PMS). Taking vitamin E by mouth seems to reduce anxiety, craving, and depression in some women with PMS.
Physical performance in elderly adults. Research suggests that increasing vitamin E intake in the diet is linked with improved physical performance and muscle strength in older people.
Scarring of tissue caused by radiation therapy. Taking vitamin E by mouth with the drug pentoxifylline seems to treat scarring caused by radiation. However, taking vitamin E alone doesn't seem to be effective.
Rheumatoid arthritis (RA). Vitamin E taken along with standard treatment is better than standard treatment alone for reducing pain in people with RA. However, this combination doesn't reduce swelling.
Sunburn. Taking high doses of vitamin E (RRR-alpha-tocopherol) by mouth together with vitamin C protects against skin inflammation after exposure to UV radiation. However, vitamin E alone doesn't provide the same benefit. Applying vitamin E to the skin, together with vitamin C and melatonin, provides some protection when used before UV exposure.
A movement disorder often caused by antipsychotic drugs (tardive dyskinesia). Taking vitamin E by mouth seems to improve symptoms associated with the movement disorder called tardive dyskinesia. However, some other research suggests that it doesn't improve symptoms, but may prevent symptoms from worsening.
Swelling (inflammation) of the eye (uveitis). Taking vitamin E with vitamin C by mouth seems to improve vision, but doesn't reduce swelling, in people with uveitis.

Recommended Dosing

The following doses have been studied in scientific research:

BY MOUTH:

For vitamin E deficiency: A typical dose in adults is 60-75 IU of RRR-alpha tocopherol (natural vitamin E) per day
For an inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED): 800-1500 mg of RRR-alpha-tocopherol or all-rac-alpha-tocopherol daily.
For low levels of red blood cells in people with long-term illness (anemia of chronic disease): 447-745 IU of vitamin E daily with erythropoietin 93-74 U/kg/week.
For a movement disorder often caused by antipsychotic drugs (tardive dyskinesia): 1600 IU of RRR-alpha-tocopherol (natural vitamin E) daily.
For improving conditions in a man that prevent him from getting a woman pregnant within a year of trying to conceive (male infertility): 298-894 IU of vitamin E daily.
For Alzheimer disease: up to 2000 IU of vitamin E daily. Combination therapy with 5 mg of donepezil (Aricept) and 1000 IU of vitamin E per day has been used for slowing memory decline in people with Alzheimer disease.
For swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (non-alcoholic steatohepatitis or NASH): 800 IU of vitamin E daily.
For an inherited brain disorder that affects movements, emotions, and thinking (Huntington disease): 3000 IU of RRR-alpha-tocopherol (natural vitamin E).
For rheumatoid arthritis (RA): 600 IU of vitamin E twice daily.
For treating the reduced benefit of nitrate therapy that happens when nitrates are used all day (nitrate tolerance): 298 IU of vitamin E three times daily.
For an inherited disorder that causes red blood cells to break down in response to stress (G6PD deficiency): 800 IU of vitamin E daily.
For premenstrual syndrome (PMS): 400 IU of RRR-alpha-tocopherol (natural vitamin E) daily.
For menstrual cramps (dysmenorrhea): 200 IU to 500 IU of vitamin E daily starting 2 days before the menstrual period and continuing through the first 3 days of bleeding. 200 IU of vitamin E with 300 mg of fish oil has also been used.
For recovery from laser eye surgery (photoreactive keratectomy): 343 IU of vitamin E (alpha-tocopheryl nicotinate) and 25,000 units of vitamin A (retinol palmitate) have been used 3 times daily for 30 days, followed by twice daily for 2 months.
For scarring of tissue caused by radiation therapy: 1000 IU of vitamin E daily in combination with 800 mg of pentoxifylline.
For swelling (inflammation) of the eye (uveitis): 149 IU of vitamin E (unspecified forms) in combination with 500 mg of vitamin C twice daily.
For preventing sunburn: 1000 IU of RRR-alpha-tocopherol (natural vitamin E) in combination with 2 grams of ascorbic acid.

APPLIED TO THE SKIN:

For treating leakage of intravenous (IV) drug from the vein into surrounding skin and tissue (extravasation): Vitamin E 10% in combination with dimethylsulfoxide (DMSO) 90% applied to the skin.
For preventing sunburn: Vitamin E in combination with topical vitamin C and melatonin applied to the skin prior to sun exposure.

CHILDREN

BY MOUTH:

For an inherited condition that affects motor control (ataxia with vitamin E deficiency or AVED): 40 mg/kg of RRR-alpha-tocopherol or all-rac-alpha-tocopherol daily.
For a blood disorder that reduces levels of protein in the blood called hemoglobin (beta-thalassemia): 298 mg of vitamin E daily for 4-8 weeks.
For scarring or hardening of blood vessels in the kidney (glomerulosclerosis): 200 Iu of vitamin E.
For treating bleeding within the skull (intracranial hemorrhage): 100 mg/kg of vitamin E (dl-alpha-tocopheryl acetate).
For treating bleeding into or around the fluid-filled areas (ventricles) of the brain (intraventricular hemorrhage): 29.8 IU/kg of vitamin E.
For swelling (inflammation) and build up of fat in the liver in people who drink little or no alcohol (non-alcoholic steatohepatitis or NASH): 400-1200 IU of vitamin E daily.

For the most benefit, it's best to take vitamin E that has been made in a lab (all-rac-alpha-tocopherol) with food.

Dosing for vitamin E can be confusing. Current guidelines show recommended dietary allowance (RDA) and tolerable upper intake limits (UL) for vitamin E in milligrams. However, most products are still labeled in International Units (IUs).

Vitamin E Supplements Frequently Asked Questions

What are the benefits of taking vitamin E?

Free radicals form as a result of normal body processes. They cause damage that shortens the life of your cells. Vitamin E is a powerful antioxidant that may help reduce free radical damage and slow the aging process of your cells, according to the National Institutes of Health (NIH).

Is it safe to take vitamin E supplements?

When taken by mouth: Vitamin E is LIKELY SAFE for most healthy people when taken by mouth. Most people do not experience any side effects when taking the recommended daily dose, which is 22.4 IU. Vitamin E is POSSIBLY UNSAFE if taken by mouth in high doses.

How much vitamin E should I take daily?

The Recommended Daily Allowance (RDA) for vitamin E is 15 milligrams a day. At this time, the American Heart Association discourages the use of high dose vitamin E supplements and promotes obtaining it from food sources. The Food and Drug Administration (FDA) regulates dietary supplements as foods, not as drugs.

What is the best form of vitamin E supplement?

Recommended daily intake of vitamin E is 15 mg (22.5 IU). **Contains more than 60% gamma-tocopherol, a form of vitamin E that some researchers believe may be more beneficial than the alpha form. +Contains mostly gamma-tocopherol. Other nuts containing gamma-tocopherol at similar levels include pistachios and pecans.

Should I take vitamin E daily?

Vitamin E deficiency can cause nerve pain (neuropathy). The recommended daily amount of vitamin E for adults is 15 milligrams a day.

Can I take vitamin E daily?

Does vitamin E cause weight gain?

In conclusion, vitamin E played an important role in the weight gain of female rats and the gain was primarily due to the increase in fat mass, irrespective of the effect of ovariectomy. The results also indicate that excessive vitamin E intake might contribute towards obesity in female rats.

What does vitamin E do to your skin?

Vitamin E helps support the immune system, cell function, and skin health. It's an antioxidant, making it effective at combating the effects of free radicals produced by the metabolism of food and toxins in the environment. Vitamin E may be beneficial at reducing UV damage to skin.

What are the side effects of taking vitamin E?

What Are Side Effects Associated with Using Vitamin E?

Gas (flatulence)
Blurred vision.
Necrotizing enterocolitis (infants)
Increased serum creatinine.
Increased risk of hemorrhagic stroke.

Is 400 mg of vitamin E safe?

When taken by mouth: Vitamin E is LIKELY SAFE for most healthy people when taken by mouth. Most people do not experience any side effects when taking the recommended daily dose, which is 22.4 IU. If you have a condition such as heart disease or diabetes, do not take doses of 400 IU/day or more.

What is the best time to take vitamin E?

Best time to take water-soluble vitamins

Water-soluble vitamins absorb best on an empty stomach. That means taking them first thing in the morning, 30 minutes prior to eating, or two hours after a meal.

Is 400 IU of vitamin E daily safe?

Daily vitamin E doses of 400 international units (IU) or more can increase the risk of death and should be avoided, researchers reported at the American Heart Association's Scientific Sessions 2004. Doses ranged from 15 to 2000 IU/day, and average intake was about 400 IU a day.

What happens if you have too much vitamin E?

Eating vitamin E in foods is not risky or harmful. In supplement form, however, high doses of vitamin E might increase the risk of bleeding (by reducing the blood's ability to form clots after a cut or injury) and of serious bleeding in the brain (known as hemorrhagic stroke).

When should I take vitamin E morning or night?

Best time to take water-soluble vitamins

Water-soluble vitamins absorb best on an empty stomach. That means taking them first thing in the morning, 30 minutes prior to eating, or two hours after a meal.

What is Vitamin E Good for sexually?

Vitamin E. Rick says vitamin E is important in increasing sex drive because it increases testosterone levels which therefore increases stamina and also helps raise desire. He added: “For men, it also enhances sperm count and motility. ... “Increased testosterone levels also help with blood flow and oxygenation of the body. .

Is Vitamin E Good for face?

It also has antioxidant and anti-inflammatory properties that make getting enough essential to your everyday health. Vitamin E is most commonly known for its benefits for skin health and appearance. It can be applied topically to your face to reduce inflammation and make your skin look younger.

Does Vitamin E make your breasts bigger?

This is the easiest way how to increase breast size naturally at home. Vitamins are is a much safer alternative to make your breast increase. You can try vitamin A, B3, C, and E which is a great way on how to enlarge the breast. including the other health benefits that they provide.

What does vitamin E do for the female body?

Vitamin E is a fat-soluble nutrient found in many foods. In the body, it acts as an antioxidant, helping to protect cells from the damage caused by free radicals. Free radicals are compounds formed when our bodies convert the food we eat into energy.

Can vitamin E help lose weight?

Vitamin E, along with vitamin C and some other antioxidants, are natural dietary defenses against this problem. “This may make sense if you are trying to reduce calories, but fat is the most common source of vitamin E in our diets, so that approach to weight loss can sometimes actually worsen a nutrient deficiency.”

Can vitamin E lighten skin?

Lightens Scars

“Vitamin E oil helps to regenerate new skin cells and can lighten brown spots or scars found on the face,” adds Dr. Mukesh Girdhar, Max Super Speciality Hospital.

Can vitamin E cause pimples?

Will vitamin E cause acne and breakouts? If you have oily or acne-prone skin, using a heavy, oil-based vitamin E product may clog your pores and cause you to break out, says Dr. Linker, but it's not because of the vitamin E—it's because any heavy product can be risky for oily or acne-prone skin.

Why should you not take vitamin E?

Other research suggests that vitamin E use might increase the risk of death in people with a severe history of heart disease, such as heart attack or stroke. Talk with your doctor before taking vitamin E if you have: A vitamin K deficiency. An eye condition in which the retina is damaged (retinitis pigmentosa)

Why is vitamin E good for your liver?

Vitamin E is a potent antioxidant that has been shown to reduce oxidative stress in NAFLD. This review summarizes the biological activities of vitamin E, with a primary focus on its therapeutic efficacy in NAFLD.

Clinical Studies

^ a b Nobili V1, et al. Effect of vitamin E on aminotransferase levels and insulin resistance in children with non-alcoholic fatty liver disease. Aliment Pharmacol Ther. (2006)
^ a b Harrison SA1, et al. Vitamin E and vitamin C treatment improves fibrosis in patients with nonalcoholic steatohepatitis. Am J Gastroenterol. (2003)
^ a b Kang JH, et al. Vitamin E, vitamin C, beta carotene, and cognitive function among women with or at risk of cardiovascular disease: The Women's Antioxidant and Cardiovascular Study. Circulation. (2009)
^ a b Blot WJ, et al. Nutrition intervention trials in Linxian, China: supplementation with specific vitamin/mineral combinations, cancer incidence, and disease-specific mortality in the general population. J Natl Cancer Inst. (1993)
^ a b Zureik M, et al. Effects of long-term daily low-dose supplementation with antioxidant vitamins and minerals on structure and function of large arteries. Arterioscler Thromb Vasc Biol. (2004)
^ a b You WC, et al. An intervention trial to inhibit the progression of precancerous gastric lesions: compliance, serum micronutrients and S-allyl cysteine levels, and toxicity. Eur J Cancer Prev. (2001)
^ a b Morrison D, et al. Vitamin C and E supplementation prevents some of the cellular adaptations to endurance-training in humans. Free Radic Biol Med. (2015)
^ a b Taylor HR, et al. Vitamin E supplementation and macular degeneration: randomised controlled trial. BMJ. (2002)
^ a b c d e Wu D1, et al. Effect of concomitant consumption of fish oil and vitamin E on T cell mediated function in the elderly: a randomized double-blind trial. J Am Coll Nutr. (2006)
^Wolf G. The discovery of the antioxidant function of vitamin E: the contribution of Henry A. Mattill. J Nutr. (2005)
^Bieri JG, McKenna MC. Expressing dietary values for fat-soluble vitamins: changes in concepts and terminology. Am J Clin Nutr. (1981)
^ a b c d e Brigelius-Flohé R, Traber MG. Vitamin E: function and metabolism. FASEB J. (1999)
^Schuelke M, et al. Treatment of ataxia in isolated vitamin E deficiency caused by alpha-tocopherol transfer protein deficiency. J Pediatr. (1999)
^Brin MF, et al. Electrophysiologic features of abetalipoproteinemia. Neurology. (1986)
^Sokol RJ, et al. Isolated vitamin E deficiency in the absence of fat malabsorption--familial and sporadic cases: characterization and investigation of causes. J Lab Clin Med. (1988)
^Weiser H, Riss G, Kormann AW. Biodiscrimination of the eight alpha-tocopherol stereoisomers results in preferential accumulation of the four 2R forms in tissues and plasma of rats. J Nutr. (1996)
^Boscoboinik D, et al. Inhibition of cell proliferation by alpha-tocopherol. Role of protein kinase C. J Biol Chem. (1991)
^Azzi A, et al. Molecular basis of alpha-tocopherol control of smooth muscle cell proliferation. Biofactors. (1998)
^Azzi A, et al. Nonantioxidant Functions of α-Tocopherol in Smooth Muscle Cells. J Nutr. (2001)
^Tran K, Proulx PR, Chan AC. Vitamin E suppresses diacylglycerol (DAG) level in thrombin-stimulated endothelial cells through an increase of DAG kinase activity. Biochim Biophys Acta. (1994)
^Kunisaki M, et al. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes.
^Cachia O, et al. α-Tocopherol Inhibits the Respiratory Burst in Human Monocytes Attenuation of p47phox Membrane Translocation and Phosphorylation. J Biol Chem. (1998)
^Cominacini L, et al. Antioxidants inhibit the expression of intercellular cell adhesion molecule-1 and vascular cell adhesion molecule-1 induced by oxidized LDL on human umbilical vein endothelial cells. Free Radic Biol Med. (1997)
^Chan AC. Vitamin E and Atherosclerosis. J Nutr. (1998)
^Tran K, et al. Vitamin E potentiates arachidonate release and phospholipase A2 activity in rat heart myoblastic cells. Biochem J. (1996)
^Tran K, Chan AC. R,R,R-alpha-tocopherol potentiates prostacyclin release in human endothelial cells. Evidence for structural specificity of the tocopherol molecule. Biochim Biophys Acta. (1990)
^ a b Pyke DD, Chan AC. Effects of vitamin E on prostacyclin release and lipid composition of the ischemic rat heart. Arch Biochem Biophys. (1990)
^ a b Szczeklik A, et al. Dietary supplementation with vitamin E in hyperlipoproteinemias: effects on plasma lipid peroxides, antioxidant activity, prostacyclin generation and platelet aggregability. Thromb Haemost. (1985)
^Péter S1, et al. The challenge of setting appropriate intake recommendations for vitamin e:. Int J Vitam Nutr Res. (2013)
^ a b c Vitamin E: Fact Sheet for Health Professionals.
^Burck U, et al. Neuromyopathy and vitamin E deficiency in man. Neuropediatrics. (1981)
^Larnaout A, et al. Friedreich's ataxia with isolated vitamin E deficiency: a neuropathological study of a Tunisian patient. Acta Neuropathol. (1997)
^Traber MG, Sies H. Vitamin E in humans: demand and delivery. Annu Rev Nutr. (1996)
^Peters SA1, Kelly FJ. Vitamin E supplementation in cystic fibrosis. J Pediatr Gastroenterol Nutr. (1996)
^Kayden HJ, Silber R, Kossmann CE. The role of vitamin E deficiency in the abnormal autohemolysis of acanthocytosis. Trans Assoc Am Physicians. (1965)
^Farrell PM, et al. The Occurrence and Effects of Human Vitamin E Deficiency: A study in Patients with Cystic Fibrosis. J Clin Invest. (1977)
^Lowsowsky MS, Leonard PJ. Evidence of vitamin E deficiency in patients with malabsorption or alcoholism and the effects of therapy. Gut. (1967)
^Colombo ML. An update on vitamin E, tocopherol and tocotrienol-perspectives. Molecules. (2010)
^Ju J, et al. Cancer-preventive activities of tocopherols and tocotrienols. Carcinogenesis. (2010)
^Drevon CA. Absorption, transport and metabolism of vitamin E. Free Radic Res Commun. (1991)
^Hosomi A, et al. Affinity for α-tocopherol transfer protein as a determinant of the biological activities of vitamin E analogs. FEBS Lett. (1997)
^ a b Fairus S, et al. Postprandial metabolic fate of tocotrienol-rich vitamin E differs significantly from that of alpha-tocopherol. Am J Clin Nutr. (2006)
^Hayes KC, Pronczuk A, Liang JS. Differences in the plasma transport and tissue concentrations of tocopherols and tocotrienols: observations in humans and hamsters. Proc Soc Exp Biol Med. (1993)
^Khosla P, et al. Postprandial levels of the natural vitamin E tocotrienol in human circulation. Antioxid Redox Signal. (2006)
^ a b c d Aggarwal BB, et al. Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases. Biochem Pharmacol. (2010)
^Han SN, et al. Differential effects of natural and synthetic vitamin E on gene transcription in murine T lymphocytes. Arch Biochem Biophys. (2010)
^Arita M, et al. a-Tocopherol transfer protein stimulates the secretion of a-tocopherol from a cultured liver cell line through a brefeldin A-insensitive pathway. Proc Natl Acad Sci USA. (1997)
^Traber MG1, Elsner A, Brigelius-Flohé R. Synthetic as compared with natural vitamin E is preferentially excreted as alpha-CEHC in human urine: studies using deuterated alpha-tocopheryl acetates. FEBS Lett. (1998)
^ a b c Bieri JG, Evarts RP. Gamma tocopherol: metabolism, biological activity and significance in human vitamin E nutrition. Am J Clin Nutr. (1974)
^Bieri JG, Evarts RP. Vitamin E activity of gamma-tocopherol in the rat, chick and hamster. J Nutr. (1974)
^ a b c Handelman GJ, et al. Oral alpha-tocopherol supplements decrease plasma gamma-tocopherol levels in humans. J Nutr. (1985)
^ a b c d e f Vatassery GT, et al. Alpha and gamma tocopherols in cerebrospinal fluid and serum from older, male, human subjects. J Am Coll Nutr. (2004)
^Cooney RV, et al. Gamma-tocopherol detoxification of nitrogen dioxide: superiority to alpha-tocopherol. Proc Natl Acad Sci USA. (1993)
^Christen S, et al. γ-Tocopherol traps mutagenic electrophiles such as NOx and complements α-tocopherol: Physiological implications. Proc Natl Acad Sci USA. (1997)
^Cooney RV, et al. Products of gamma-tocopherol reaction with NO2 and their formation in rat insulinoma (RINm5F) cells. Free Radic Biol Med. (1995)
^Yu W, et al. Anticancer actions of natural and synthetic vitamin E forms: RRR-alpha-tocopherol blocks the anticancer actions of gamma-tocopherol. Mol Nutr Food Res. (2009)
^ a b Kamal-Eldin A, Appelqvist LA. The chemistry and antioxidant properties of tocopherols and tocotrienols. Lipids. (1996)
^ a b Serbinova E, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radical Bio Med. (1991)
^Ong FB, et al. Glutathione S-transferase and gamma-glutamyl transpeptidase activities in cultured rat hepatocytes treated with tocotrienol and tocopherol. Comp Biochem Physiol C Pharmacol Toxicol Endocrinol. (1993)
^Yu W, et al. Induction of apoptosis in human breast cancer cells by tocopherols and tocotrienols. Nutr Cancer. (1999)
^McIntyre BS, et al. Antiproliferative and apoptotic effects of tocopherols and tocotrienols on preneoplastic and neoplastic mouse mammary epithelial cells. Proc Soc Exp Biol Med. (2000)
^Mazlan M, et al. Comparative effects of a-tocopherol and g-tocotrienol against hydrogen peroxide induced apoptosis on primary-cultured astrocytes. J Neurol Sci. (2006)
^Sen CK, et al. Molecular Basis of Vitamin E Action TOCOTRIENOL POTENTLY INHIBITS GLUTAMATE-INDUCED pp60c-Src KINASE ACTIVATION AND DEATH OF HT4 NEURONAL CELLS. J Biol Chem. (2000)
^Komiyama K, et al. Studies on the biological activity of tocotrienols. Chem Pharm Bull (Tokyo). (1989)
^ a b Ahmad NS, et al. TOCOTRIENOL OFFERS BETTER PROTECTION THAN TOCOPHEROL FROM FREE RADICAL-INDUCED DAMAGE OF RAT BONE. Clin Exp Pharmacol Physiol. (2005)
^Gu JY1, et al. Dietary effect of tocopherols and tocotrienols on the immune function of spleen and mesenteric lymph node lymphocytes in Brown Norway rats. Biosci Biotechnol Biochem. (1999)
^Norazlina M, et al. Effects of vitamin E supplementation on bone metabolism in nicotine-treated rats. Singapore Med J. (2007)
^Hermizi H, et al. Beneficial Effects of Tocotrienol and Tocopherol on Bone Histomorphometric Parameters in Sprague–Dawley Male Rats After Nicotine Cessation. Calcif Tissue Int. (2009)
^ a b Mehat MZ, et al. Beneficial effects of vitamin E isomer supplementation on static and dynamic bone histomorphometry parameters in normal male rats. J Bone Miner Metab. (2010)
^Shuid AN, et al. Vitamin E exhibits bone anabolic actions in normal male rats.
^ a b c d e Freedman JE1, et al. alpha-Tocopherol and protein kinase C inhibition enhance platelet-derived nitric oxide release. FASEB J. (2000)
^ a b c Freedman JE1, et al. alpha-tocopherol inhibits aggregation of human platelets by a protein kinase C-dependent mechanism. Circulation. (1996)
^ a b Kunisaki M1, et al. Vitamin E normalizes diacylglycerol-protein kinase C activation induced by hyperglycemia in rat vascular tissues. Diabetes. (1996)
^ a b c Lee IK1, et al. d-Alpha-tocopherol prevents the hyperglycemia induced activation of diacylglycerol (DAG)-protein kinase C (PKC) pathway in vascular smooth muscle cell by an increase of DAG kinase activity. Diabetes Res Clin Pract. (1999)
^Pfannkuche HJ, Kaever V, Resch K. A possible role of protein kinase C in regulating prostaglandin synthesis of mouse peritoneal macrophages. Biochem Biophys Res Commun. (1986)
^ a b c d Beharka AA1, et al. Macrophage prostaglandin production contributes to the age-associated decrease in T cell function which is reversed by the dietary antioxidant vitamin E. Mech Ageing Dev. (1997)
^Kunisaki M1, et al. Vitamin E prevents diabetes-induced abnormal retinal blood flow via the diacylglycerol-protein kinase C pathway. Am J Physiol. (1995)
^Newton AC. Protein kinase C: structural and spatial regulation by phosphorylation, cofactors, and macromolecular interactions. Chem Rev. (2001)
^ a b Bjørneboe A, et al. Transport and distribution of alpha-tocopherol in lymph, serum and liver cells in rats. Biochim Biophys Acta. (1986)
^Bjørneboe A, Bjørneboe GE, Drevon CA. Absorption, transport and distribution of vitamin E. J Nutr. (1990)
^ a b Vatassery GT, et al. Vitamin E (tocopherols) in human cerebrospinal fluid. Am J Clin Nutr. (1991)
^Gallo-Torres HE, Weber F, Wiss O. The effect of different dietary lipids on the lymphatic appearance of vitamin E. Int J Vitam Nutr Res. (1971)
^Yáñez JA, et al. Intestinal lymphatic transport for drug delivery. Adv Drug Deliv Rev. (2011)
^Trevaskis NL, Porter CJ, Charman WN. Bile increases intestinal lymphatic drug transport in the fasted rat. Pharm Res. (2005)
^Caliph SM, Charman WN, Porter CJ. Effect of short-, medium-, and long-chain fatty acid-based vehicles on the absolute oral bioavailability and intestinal lymphatic transport of halofantrine and assessment of mass balance in lymph-cannulated and non-cannulated rats. J Pharm Sci. (2000)
^O'Driscoll CM. Lipid-based formulations for intestinal lymphatic delivery. Eur J Pharm Sci. (2002)
^Karpf DM, et al. Influence of the type of surfactant and the degree of dispersion on the lymphatic transport of halofantrine in conscious rats. Pharm Res. (2004)
^Chang T, Benet LZ, Hebert MF. The effect of water-soluble vitamin E on cyclosporine pharmacokinetics in healthy volunteers. Clin Pharmacol Ther. (1996)
^Mu L, Feng SS. A novel controlled release formulation for the anticancer drug paclitaxel (Taxol): PLGA nanoparticles containing vitamin E TPGS. J Control Release. (2003)
^Fan Z, et al. A new function of Vitamin E-TPGS in the intestinal lymphatic transport of lipophilic drugs: enhancing the secretion of chylomicrons. Int J Pharm. (2013)
^ a b Trevithick JR, Mitton KP. Uptake of vitamin E succinate by the skin, conversion to free vitamin E, and transport to internal organs. Biochem Mol Biol Int. (1999)
^Trevithick JR, Mitton KP. Topical application and uptake of vitamin E acetate by the skin and conversion to free vitamin E. Biochem Mol Biol Int. (1993)
^ a b c d e f Kitagawa M1, Mino M. Effects of elevated d-alpha(RRR)-tocopherol dosage in man. J Nutr Sci Vitaminol (Tokyo). (1989)
^ a b Meydani SN1, et al. Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects. Am J Clin Nutr. (1990)
^Wander RC1, et al. alpha-Tocopherol influences in vivo indices of lipid peroxidation in postmenopausal women given fish oil. J Nutr. (1996)
^Baker H, et al. Comparison of plasma alpha and gamma tocopherol levels following chronic oral administration of either all-rac-alpha-tocopheryl acetate or RRR-alpha-tocopheryl acetate in normal adult male subjects. Am J Clin Nutr. (1986)
^Galli F1, et al. gamma-Tocopherol biokinetics and transformation in humans. Free Radic Res. (2003)
^ a b Singh I1, et al. Effects of gamma-tocopherol supplementation on thrombotic risk factors. Asia Pac J Clin Nutr. (2007)
^Clarke MW1, et al. Supplementation with mixed tocopherols increases serum and blood cell gamma-tocopherol but does not alter biomarkers of platelet activation in subjects with type 2 diabetes. Am J Clin Nutr. (2006)
^Traber MG1, Kayden HJ. Alpha-tocopherol as compared with gamma-tocopherol is preferentially secreted in human lipoproteins. Ann N Y Acad Sci. (1989)
^Traber MG. Regulation of human plasma vitamin E. Adv Pharmacol. (1997)
^Jiang X-C, et al. Phospholipid Transfer Protein Deficiency Protects Circulating Lipoproteins from Oxidation Due to the Enhanced Accumulation of Vitamin E. J Biol Chem. (2002)
^ a b Desrumaux C, et al. Phospholipid transfer protein (PLTP) deficiency reduces brain vitamin E content and increases anxiety in mice. FASEB J. (2005)
^Gander R, et al. Molecular characterization of rabbit phospholipid transfer protein: choroid plexus and ependyma synthesize high levels of phospholipid transfer protein. J Lipid Res. (2002)
^Albers JJ, Cheung MC. Emerging roles for phospholipid transfer protein in lipid and lipoprotein metabolism. Curr Opin Lipidol. (2004)
^Day JR1, et al. Complete cDNA encoding human phospholipid transfer protein from human endothelial cells. J Biol Chem. (1994)
^Albers JJ1, et al. Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies. Biochim Biophys Acta. (1995)
^ a b c d Tsuduki T1, et al. Tocotrienol (unsaturated vitamin E) suppresses degranulation of mast cells and reduces allergic dermatitis in mice. J Oleo Sci. (2013)
^ a b c de Bustos F, et al. Cerebrospinal fluid levels of alpha-tocopherol in amyotrophic lateral sclerosis. J Neural Transm. (1998)
^Schippling S, et al. Increased lipoprotein oxidation in Alzheimer's disease. Free Radic Biol Med. (2000)
^ a b Schultz M1, et al. Novel urinary metabolite of alpha-tocopherol, 2,5,7,8-tetramethyl-2(2'-carboxyethyl)-6-hydroxychroman, as an indicator of an adequate vitamin E supply. Am J Clin Nutr. (1995)
^ a b Parker RS, Sontag TJ, Swanson JE. Cytochrome P4503A-dependent metabolism of tocopherols and inhibition by sesamin. Biochem Biophys Res Commun. (2000)
^Swanson JE, et al. Urinary excretion of 2,7, 8-trimethyl-2-(beta-carboxyethyl)-6-hydroxychroman is a major route of elimination of gamma-tocopherol in humans. J Lipid Res. (1999)
^ a b c d Lodge JK, et al. Alpha- and gamma-tocotrienols are metabolized to carboxyethyl-hydroxychroman derivatives and excreted in human urine. Lipids. (2001)
^Birringer M, Drogan D, Brigelius-Flohe R. Tocopherols are metabolized in HepG2 cells by side chain omega-oxidation and consecutive beta-oxidation. Free Radic Biol Med. (2001)
^ a b c d e Bruno RS1, et al. Lower plasma alpha-carboxyethyl-hydroxychroman after deuterium-labeled alpha-tocopherol supplementation suggests decreased vitamin E metabolism in smokers. Am J Clin Nutr. (2005)
^Ross AB, et al. Cereal Alkylresorcinols Elevate γ-Tocopherol Levels in Rats and Inhibit γ-Tocopherol Metabolism In Vitro. J Nutr. (2004)
^Birringer M1, et al. Identities and differences in the metabolism of tocotrienols and tocopherols in HepG2 cells. J Nutr. (2002)
^Stahl W1, et al. Quantification of the alpha- and gamma-tocopherol metabolites 2,5,7, 8-tetramethyl-2-(2'-carboxyethyl)-6-hydroxychroman and 2,7, 8-trimethyl-2-(2'-carboxyethyl)-6-hydroxychroman in human serum. Anal Biochem. (1999)
^Schuelke M1, et al. Urinary alpha-tocopherol metabolites in alpha-tocopherol transfer protein-deficient patients. J Lipid Res. (2000)
^Lodge JK, et al. A rapid method for the extraction and determination of vitamin E metabolites in human urine. J Lipid Res. (2000)
^Bhatti P1, et al. Lead exposure, polymorphisms in genes related to oxidative stress, and risk of adult brain tumors. Cancer Epidemiol Biomarkers Prev. (2009)
^Prokopowicz A1, et al. Effect of occupational lead exposure on α- and γ-tocopherol concentration in plasma. Occup Environ Med. (2013)
^ a b Ebuehi OA1, Ogedegbe RA, Ebuehi OM. Oral administration of vitamin C and vitamin E ameliorates lead-induced hepatotoxicity and oxidative stress in the rat brain. Nig Q J Hosp Med. (2012)
^Fahim MA1, Tariq S, Adeghate E. Vitamin E modifies the ultrastructure of testis and epididymis in mice exposed to lead intoxication. Ann Anat. (2013)
^Ayinde OC1, Ogunnowo S, Ogedegbe RA. Influence of Vitamin C and Vitamin E on testicular zinc content and testicular toxicity in lead exposed albino rats. BMC Pharmacol Toxicol. (2012)
^Rendón-Ramírez AL1, et al. Effect of vitamin E and C supplementation on oxidative damage and total antioxidant capacity in lead-exposed workers. Environ Toxicol Pharmacol. (2014)
^Nito C1, et al. Role of the p38 mitogen-activated protein kinase/cytosolic phospholipase A2 signaling pathway in blood-brain barrier disruption after focal cerebral ischemia and reperfusion. J Cereb Blood Flow Metab. (2008)
^Khanna S1, et al. Nanomolar vitamin E alpha-tocotrienol inhibits glutamate-induced activation of phospholipase A2 and causes neuroprotection. J Neurochem. (2010)
^ a b c Khanna S1, et al. Molecular basis of vitamin E action: tocotrienol modulates 12-lipoxygenase, a key mediator of glutamate-induced neurodegeneration. J Biol Chem. (2003)
^ a b c Khanna S1, et al. Characterization of the potent neuroprotective properties of the natural vitamin E alpha-tocotrienol. J Neurochem. (2006)
^O'Byrne D1, et al. Studies of LDL oxidation following alpha-, gamma-, or delta-tocotrienyl acetate supplementation of hypercholesterolemic humans. Free Radic Biol Med. (2000)
^ a b Sen CK1, et al. Molecular basis of vitamin E action. Tocotrienol potently inhibits glutamate-induced pp60(c-Src) kinase activation and death of HT4 neuronal cells. J Biol Chem. (2000)
^ a b c Heslop KE1, et al. Serotonin metabolism and release in frontal cortex of rats on a vitamin E-deficient diet. J Neurochem. (1996)
^ a b Castaño A1, et al. Changes in the turnover of monoamines in prefrontal cortex of rats fed on vitamin E-deficient diet. J Neurochem. (1992)
^Castaño A1, et al. Turnover of monoamines in hippocampus of rats fed on vitamin E-deficient diet. Brain Res. (1993)
^Leppälä JM, et al. Controlled trial of alpha-tocopherol and beta-carotene supplements on stroke incidence and mortality in male smokers. Arterioscler Thromb Vasc Biol. (2000)
^Törnwall ME, et al. Postintervention effect of alpha tocopherol and beta carotene on different strokes: a 6-year follow-up of the Alpha Tocopherol, Beta Carotene Cancer Prevention Study. Stroke. (2004)
^Leppälä JM, et al. Vitamin E and beta carotene supplementation in high risk for stroke: a subgroup analysis of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study. Arch Neurol. (2000)
^ a b c d Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. The effect of vitamin E and beta carotene on the incidence of lung cancer and other cancers in male smokers. N Engl J Med. (1994)
^Dereska NH, et al. Short-term, moderate dosage Vitamin E supplementation may have no effect on platelet aggregation, coagulation profile, and bleeding time in healthy individuals. J Surg Res. (2006)
^Lee IM1, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women's Health Study: a randomized controlled trial. JAMA. (2005)
^ a b Buring JE. Aspirin prevents stroke but not MI in women; vitamin E has no effect on CV disease or cancer. Cleve Clin J Med. (2006)
^ a b Lonn E1, et al. Effects of long-term vitamin E supplementation on cardiovascular events and cancer: a randomized controlled trial. JAMA. (2005)
^Gohil K, et al. Gene expression profile of oxidant stress and neurodegeneration in transgenic mice deficient in alpha-tocopherol transfer protein. Free Radic Biol Med. (2003)
^ a b c Terada Y, et al. Dietary vitamin E deficiency increases anxiety-like behavior in juvenile and adult rats. Biosci Biotechnol Biochem. (2011)
^Okura Y, et al. Dietary vitamin E deficiency increases anxiety-related behavior in rats under stress of social isolation. Biofactors. (2009)
^ a b Kang JH, et al. A randomized trial of vitamin E supplementation and cognitive function in women. Arch Intern Med. (2006)
^ a b c d e Economides PA1, et al. The effect of vitamin E on endothelial function of micro- and macrocirculation and left ventricular function in type 1 and type 2 diabetic patients. Diabetes. (2005)
^ a b Yusuf S1, et al. Vitamin E supplementation and cardiovascular events in high-risk patients. The Heart Outcomes Prevention Evaluation Study Investigators. N Engl J Med. (2000)
^ a b c d Esterbauer H, et al. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr. (1991)
^Itabe H. Oxidative modification of LDL: its pathological role in atherosclerosis. Clin Rev Allergy Immunol. (2009)
^Esterbauer H, et al. Vitamin E and other Lipophilic Antioxidants Protect LDL against Oxidation. Eur J Lipid Sci Technol. (1989)
^ a b Skyrme-Jones RA1, et al. Vitamin E supplementation improves endothelial function in type I diabetes mellitus: a randomized, placebo-controlled study. J Am Coll Cardiol. (2000)
^Stein JH, McBride PE. Hyperhomocysteinemia and atherosclerotic vascular disease: pathophysiology, screening, and treatment. off. Arch Intern Med. (1998)
^Can C, et al. Vascular endothelial dysfunction associated with elevated serum homocysteine levels in rat adjuvant arthritis: effect of vitamin E administration. Life Sci. (2002)
^Weiss N, et al. Overexpression of cellular glutathione peroxidase rescues homocyst(e)ine-induced endothelial dysfunction. Proc Natl Acad Sci U S A. (2001)
^Brude IR, et al. Plasma homocysteine concentration related to diet, endothelial function and mononuclear cell gene expression among male hyperlipidaemic smokers. Eur J Clin Invest. (1999)
^ a b c d e McAnulty SR, et al. Effect of alpha-tocopherol supplementation on plasma homocysteine and oxidative stress in highly trained athletes before and after exhaustive exercise. J Nutr Biochem. (2005)
^Rimm EB, et al. Vitamin E consumption and the risk of coronary heart disease in men. N Engl J Med. (1993)
^Stampfer MJ, et al. Vitamin E consumption and the risk of coronary disease in women. N Engl J Med. (1993)
^Hodis HN1, et al. Alpha-tocopherol supplementation in healthy individuals reduces low-density lipoprotein oxidation but not atherosclerosis: the Vitamin E Atherosclerosis Prevention Study (VEAPS). Circulation. (2002)
^ a b Waters DD1, et al. Effects of hormone replacement therapy and antioxidant vitamin supplements on coronary atherosclerosis in postmenopausal women: a randomized controlled trial. JAMA. (2002)
^Salonen RM1, et al. Six-year effect of combined vitamin C and E supplementation on atherosclerotic progression: the Antioxidant Supplementation in Atherosclerosis Prevention (ASAP) Study. Circulation. (2003)
^ a b Rasool AH1, et al. Dose dependent elevation of plasma tocotrienol levels and its effect on arterial compliance, plasma total antioxidant status, and lipid profile in healthy humans supplemented with tocotrienol rich vitamin E. J Nutr Sci Vitaminol (Tokyo). (2006)
^ a b Gazis A1, et al. Effect of oral vitamin E (alpha-tocopherol) supplementation on vascular endothelial function in Type 2 diabetes mellitus. Diabet Med. (1999)
^ a b Corrigan JJ Jr. Coagulation problems relating to vitamin E. Am J Pediatr Hematol Oncol. (1979)
^ a b c Marsh SA1, Coombes JS. Vitamin E and alpha-lipoic acid supplementation increase bleeding tendency via an intrinsic coagulation pathway. Clin Appl Thromb Hemost. (2006)
^Radomski MW1, Palmer RM, Moncada S. Endogenous nitric oxide inhibits human platelet adhesion to vascular endothelium. Lancet. (1987)
^Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature. (1986)
^Rubanyi GM, Vanhoutte PM. Superoxide anions and hyperoxia inactivate endothelium-derived relaxing factor. Am J Physiol. (1986)
^Hirata K1, et al. Inhibition of endothelial nitric oxide synthase activity by protein kinase C. Hypertension. (1995)
^Ford I1, et al. The effects of treatment with alpha-lipoic acid or evening primrose oil on vascular hemostatic and lipid risk factors, blood flow, and peripheral nerve conduction in the streptozotocin-diabetic rat. Metabolism. (2001)
^Kagan VE1, et al. Recycling of vitamin E in human low density lipoproteins. J Lipid Res. (1992)
^Helson L. The effect of intravenous vitamin E and menadiol sodium diphosphate on vitamin K dependent clotting factors. Thromb Res. (1984)
^Corrigan JJ Jr. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci. (1982)
^ a b Tsai AC, et al. Study on the effect of megavitamin E supplementation in man. Am J Clin Nutr. (1978)
^ a b c Meydani SN1, et al. Assessment of the safety of supplementation with different amounts of vitamin E in healthy older adults. Am J Clin Nutr. (1998)
^ a b Glynn RJ1, et al. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women's Health Study. Circulation. (2007)
^Brown BG1, et al. Simvastatin and niacin, antioxidant vitamins, or the combination for the prevention of coronary disease. N Engl J Med. (2001)
^Cheung MC1, et al. Antioxidant supplements block the response of HDL to simvastatin-niacin therapy in patients with coronary artery disease and low HDL. Arterioscler Thromb Vasc Biol. (2001)
^Atger V1, et al. High-density lipoprotein subfractions as markers of early atherosclerosis. PCVMETRA Group. Prévention Cardio-Vasculaire en Medecene du Travail. Am J Cardiol. (1995)
^Singh U1, et al. High-dose alpha-tocopherol therapy does not affect HDL subfractions in patients with coronary artery disease on statin therapy. Clin Chem. (2007)
^Kunisaki M1, et al. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. (1994)
^Kunisaki M1, et al. Prevention of diabetes-induced abnormal retinal blood flow by treatment with d-alpha-tocopherol. Biofactors. (1998)
^Way KJ1, Katai N, King GL. Protein kinase C and the development of diabetic vascular complications. Diabet Med. (2001)
^Idris I1, Gray S, Donnelly R. Protein kinase C activation: isozyme-specific effects on metabolism and cardiovascular complications in diabetes. Diabetologia. (2001)
^Bursell SE1, King GL. Can protein kinase C inhibition and vitamin E prevent the development of diabetic vascular complications. Diabetes Res Clin Pract. (1999)
^ a b c d e Wu JH1, et al. Effects of alpha-tocopherol and mixed tocopherol supplementation on markers of oxidative stress and inflammation in type 2 diabetes. Clin Chem. (2007)
^ a b Shab-Bidar S1, Mazloum Z, Mousavi-Shirazifard Z. Daily vitamin E supplementation does not improve metabolic and glycemic control in type 2 diabetic patients: a double blinded randomized controlled trial. J Diabetes. (2013)
^Evans JL1, et al. Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction. Diabetes. (2003)
^Ceriello A1, Motz E. Is oxidative stress the pathogenic mechanism underlying insulin resistance, diabetes, and cardiovascular disease? The common soil hypothesis revisited. Arterioscler Thromb Vasc Biol. (2004)
^Laight DW1, et al. Pro-oxidant challenge in vivo provokes the onset of NIDDM in the insulin resistant obese Zucker rat. Br J Pharmacol. (1999)
^Liu S1, et al. Vitamin E and risk of type 2 diabetes in the women's health study randomized controlled trial. Diabetes. (2006)
^Song Y1, et al. Effects of vitamins C and E and beta-carotene on the risk of type 2 diabetes in women at high risk of cardiovascular disease: a randomized controlled trial. Am J Clin Nutr. (2009)
^Reunanen A1, et al. Serum antioxidants and risk of non-insulin dependent diabetes mellitus. Eur J Clin Nutr. (1998)
^Polidori MC1, et al. Plasma levels of lipophilic antioxidants in very old patients with type 2 diabetes. Diabetes Metab Res Rev. (2000)
^Abahusain MA1, et al. Retinol, alpha-tocopherol and carotenoids in diabetes. Eur J Clin Nutr. (1999)
^Vatassery GT, Morley JE, Kuskowski MA. Vitamin E in plasma and platelets of human diabetic patients and control subjects.
^Sampson MJ1, et al. Plasma F2 isoprostanes: direct evidence of increased free radical damage during acute hyperglycemia in type 2 diabetes. Diabetes Care. (2002)
^ a b Winterbone MS1, et al. Pro-oxidant effect of alpha-tocopherol in patients with type 2 diabetes after an oral glucose tolerance test--a randomised controlled trial. Cardiovasc Diabetol. (2007)
^ a b Sampson MJ1, et al. Increased DNA oxidative susceptibility without increased plasma LDL oxidizability in Type II diabetes: effects of alpha-tocopherol supplementation. Clin Sci (Lond). (2001)
^Beckman JA1, et al. Oral antioxidant therapy improves endothelial function in Type 1 but not Type 2 diabetes mellitus. Am J Physiol Heart Circ Physiol. (2003)
^Ostrowski K, Schjerling P, Pedersen BK. Physical activity and plasma interleukin-6 in humans--effect of intensity of exercise. Eur J Appl Physiol. (2000)
^Penkowa M, et al. Immunohistochemical detection of interleukin-6 in human skeletal muscle fibers following exercise. FASEB J. (2003)
^Steensberg A, et al. Production of interleukin-6 in contracting human skeletal muscles can account for the exercise-induced increase in plasma interleukin-6. J Physiol. (2000)
^Begue G, et al. Early activation of rat skeletal muscle IL-6/STAT1/STAT3 dependent gene expression in resistance exercise linked to hypertrophy. PLoS One. (2013)
^Davies KJ, et al. Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun. (1982)
^Kosmidou I, et al. Production of interleukin-6 by skeletal myotubes: role of reactive oxygen species. Am J Respir Cell Mol Biol. (2002)
^Petersen AC, et al. Infusion with the antioxidant N-acetylcysteine attenuates early adaptive responses to exercise in human skeletal muscle. Acta Physiol (Oxf). (2012)
^Vassilakopoulos T, et al. Antioxidants attenuate the plasma cytokine response to exercise in humans. J Appl Physiol (1985). (2003)
^ a b Fischer CP, et al. Supplementation with vitamins C and E inhibits the release of interleukin-6 from contracting human skeletal muscle. J Physiol. (2004)
^Quintanilha AT, et al. Membrane effects of vitamin E deficiency: bioenergetic and surface charge density studies of skeletal muscle and liver mitochondria. Ann N Y Acad Sci. (1982)
^Thomas PK, et al. Myopathy in vitamin E deficient rats: muscle fibre necrosis associated with disturbances of mitochondrial function. J Anat. (1993)
^ a b Rafique R, Schapira AH, Cooper JM. Sensitivity of respiratory chain activities to lipid peroxidation: effect of vitamin E deficiency. Biochem J. (2001)
^Amelink GJ, et al. Exercise-induced muscle damage in the rat: the effect of vitamin E deficiency. Pflugers Arch. (1991)
^ a b Rokitzki L, et al. alpha-Tocopherol supplementation in racing cyclists during extreme endurance training. Int J Sport Nutr. (1994)
^Selley ML1, et al. Occurrence of (E)-4-hydroxy-2-nonenal in plasma and synovial fluid of patients with rheumatoid arthritis and osteoarthritis. Ann Rheum Dis. (1992)
^Merry P1, et al. Oxygen free radicals, inflammation, and synovitis: and synovitis: the current status. Ann Rheum Dis. (1989)
^Lunec J, et al. Free-radical oxidation (peroxidation) products in serum and synovial fluid in rheumatoid arthritis. J Rheumatol. (1981)
^Fairburn K1, et al. Alpha-tocopherol, lipids and lipoproteins in knee-joint synovial fluid and serum from patients with inflammatory joint disease. Clin Sci (Lond). (1992)
^Wasil M1, et al. Alpha-tocopherol status in patients with rheumatoid arthritis: relationship to antioxidant activity. Biochem Soc Trans. (1992)
^Karlson EW1, et al. Vitamin E in the primary prevention of rheumatoid arthritis: the Women's Health Study. Arthritis Rheum. (2008)
^Manolagas SC1, Parfitt AM. What old means to bone. Trends Endocrinol Metab. (2010)
^Fujita K1, et al. Vitamin E decreases bone mass by stimulating osteoclast fusion. Nat Med. (2012)
^Yasunaga T, et al. Effect of vitamin E as an immunopotentiation agent for mice at optimal dosage and its toxicity at high dosage. J Nutr. (1982)
^Aburto A1, Britton WM. Effects of different levels of vitamins A and E on the utilization of cholecalciferol by broiler chickens. Poult Sci. (1998)
^Shuid AN1, et al. Effects of α-tocopherol on the early phase of osteoporotic fracture healing. J Orthop Res. (2011)
^Mohamad S1, et al. The effects of alpha-tocopherol supplementation on fracture healing in a postmenopausal osteoporotic rat model. Clinics (Sao Paulo). (2012)
^ a b c d Michaëlsson K1, et al. Intake and serum concentrations of α-tocopherol in relation to fractures in elderly women and men: 2 cohort studies. Am J Clin Nutr. (2014)
^D'Adamo CR1, et al. Serum vitamin E concentrations among highly functioning hip fracture patients are higher than in nonfracture controls. Nutr Res. (2011)
^D'Adamo CR1, et al. Serum vitamin E concentrations and recovery of physical function during the year after hip fracture. J Gerontol A Biol Sci Med Sci. (2011)
^Wolf RL1, et al. Lack of a relation between vitamin and mineral antioxidants and bone mineral density: results from the Women's Health Initiative. Am J Clin Nutr. (2005)
^Meydani SN, Han SN, Wu D}journal=Immunol Rev. Vitamin E and immune response in the aged: molecular mechanisms and clinical implications.
^ a b Wu D, et al. In vitro supplementation with different tocopherol homologues can affect the function of immune cells in old mice. Free Radic Biol Med. (2000)
^ a b c d Pallast EG1, et al. Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons. Am J Clin Nutr. (1999)
^ a b Adolfsson O1, Huber BT, Meydani SN. Vitamin E-enhanced IL-2 production in old mice: naive but not memory T cells show increased cell division cycling and IL-2-producing capacity. J Immunol. (2001)
^Cakman I1, et al. Dysregulation between TH1 and TH2 T cell subpopulations in the elderly. Mech Ageing Dev. (1996)
^Nijhuis EW1, et al. Age-related increase in the fraction of CD27-CD4+ T cells and IL-4 production as a feature of CD4+ T cell differentiation in vivo. Clin Exp Immunol. (1994)
^ a b Radhakrishnan AK1, et al. Daily supplementation of tocotrienol-rich fraction or alpha-tocopherol did not induce immunomodulatory changes in healthy human volunteers. Br J Nutr. (2009)
^ a b c Mahalingam D1, et al. Effects of supplementation with tocotrienol-rich fraction on immune response to tetanus toxoid immunization in normal healthy volunteers. Eur J Clin Nutr. (2011)
^Paliogianni F1, Boumpas DT. Prostaglandin E2 inhibits the nuclear transcription of the human interleukin 2, but not the Il-4, gene in human T cells by targeting transcription factors AP-1 and NF-AT. Cell Immunol. (1996)
^Gold KN1, Weyand CM, Goronzy JJ. Modulation of helper T cell function by prostaglandins. Arthritis Rheum. (1994)
^Cipollone F1, et al. Association between 5-lipoxygenase expression and plaque instability in humans. Arterioscler Thromb Vasc Biol. (2005)
^Jiang Q1, Ames BN. Gamma-tocopherol, but not alpha-tocopherol, decreases proinflammatory eicosanoids and inflammation damage in rats. FASEB J. (2003)
^ a b Zingg JM, et al. In vivo regulation of gene transcription by alpha- and gamma-tocopherol in murine T lymphocytes. Arch Biochem Biophys. (2013)
^Symbol Report: SLC25A30.
^Makinodan T, Kay MM. Age influence on the immune system. Adv Immunol. (1980)
^Paganelli R1, et al. Humoral immunity in aging. Aging (Milano). (1994)
^Fülöp T Jr. Signal transduction changes in granulocytes and lymphocytes with ageing. Immunol Lett. (1994)
^ a b c d Meydani SN1, et al. Vitamin E supplementation and in vivo immune response in healthy elderly subjects. A randomized controlled trial. JAMA. (1997)
^Zingg JM1, Meydani M, Azzi A. alpha-Tocopheryl phosphate--an active lipid mediator. Mol Nutr Food Res. (2010)
^ a b c Hemmerling J1, et al. alpha-Tocopherol enhances degranulation in RBL-2H3 mast cells. Mol Nutr Food Res. (2010)
^Nell S1, et al. PCR-verified microarray analysis and functional in vitro studies indicate a role of alpha-tocopherol in vesicular transport. Free Radic Res. (2007)
^Komai-Koma M1, et al. Interleukin-33 amplifies IgE synthesis and triggers mast cell degranulation via interleukin-4 in naïve mice. Allergy. (2012)
^Troisi RJ1, et al. A prospective study of diet and adult-onset asthma. Am J Respir Crit Care Med. (1995)
^Kelly FJ, et al. Altered lung antioxidant status in patients with mild asthma. Lancet. (1999)
^Baker JC1, et al. Dietary antioxidants and magnesium in type 1 brittle asthma: a case control study. Thorax. (1999)
^Pearson PJ1, et al. Vitamin E supplements in asthma: a parallel group randomised placebo controlled trial. Thorax. (2004)
^Meydani SN1, et al. Vitamin E and respiratory tract infections in elderly nursing home residents: a randomized controlled trial. JAMA. (2004)
^ a b c Radhakrishnan AK1, et al. Supplementation with natural forms of vitamin E augments antigen-specific TH1-type immune response to tetanus toxoid. Biomed Res Int. (2013)
^ a b Han SN1, et al. Vitamin E supplementation increases T helper 1 cytokine production in old mice infected with influenza virus. Immunology. (2000)
^Hsieh CS1, et al. Development of TH1 CD4+ T cells through IL-12 produced by Listeria-induced macrophages. Science. (1993)
^Samuel CE. Antiviral actions of interferons. Clin Microbiol Rev. (2001)
^Sundaram ME1, et al. Vitamin E, vitamin A, and zinc status are not related to serologic response to influenza vaccine in older adults: an observational prospective cohort study. Nutr Res. (2014)
^Gupta S, Kumar H, Soni J. Effect of Vitamin E and selenium supplementation on concentrations of plasma cortisol and erythrocyte lipid peroxides and the incidence of retained fetal membranes in crossbred dairy cattle. Theriogenology. (2005)
^Dimri U, et al. Effect of vitamin E and selenium supplementation on oxidative stress indices and cortisol level in blood in water buffaloes during pregnancy and early postpartum period. Trop Anim Health Prod. (2010)
^Sathya A, et al. Vitamin E and selenium supplementation reduces plasma cortisol and oxidative stress in dystocia-affected buffaloes. Vet Res Commun. (2007)
^Montalvo CP, et al. Short communication: effect of vitamins E and C on cortisol production by bovine adrenocortical cells in vitro. J Dairy Sci. (2011)
^Davison G, Gleeson M, Phillips S. Antioxidant supplementation and immunoendocrine responses to prolonged exercise. Med Sci Sports Exerc. (2007)
^McKenna TM, Woolf PD. Prolactin metabolic clearance and resistance to dopaminergic suppression in acute uremia. Endocrinology. (1985)
^Veldhuis JD, et al. Neuroendocrine alterations in the somatotropic and lactotropic axes in uremic men. Eur J Endocrinol. (1994)
^Yeksan M, et al. Effect of vitamin E therapy on sexual functions of uremic patients in hemodialysis. Int J Artif Organs. (1992)
^ a b Meydani SN1, et al. Assessment of the safety of high-dose, short-term supplementation with vitamin E in healthy older adults. Am J Clin Nutr. (1994)
^Farrell PM1, Bieri JG. Megavitamin E supplementation in man. Am J Clin Nutr. (1975)
^Esterbauer H, et al. Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr. (1991)
^Burton GW, Joyce A, Ingold KU. Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes. Arch Biochem Biophys. (1983)
^Ingold KU, et al. Vitamin E remains the major lipid-soluble, chain-breaking antioxidant in human plasma even in individuals suffering severe vitamin E deficiency. Arch Biochem Biophys. (1987)
^Ham AJ, Liebler DC. Antioxidant reactions of vitamin E in the perfused rat liver: product distribution and effect of dietary vitamin E supplementation. Arch Biochem Biophys. (1997)
^ a b Stephens NG, et al. Randomised controlled trial of vitamin E in patients with coronary disease: Cambridge Heart Antioxidant Study (CHAOS. Lancet. (1996)
^ a b Davi G, et al. In vivo formation of 8-Epi-prostaglandin F2 alpha is increased in hypercholesterolemia. Arterioscler Thromb Vasc Biol. (1997)
^Motoyama T, et al. Vitamin E administration improves impairment of endothelium-dependent vasodilation in patients with coronary spastic angina. J Am Coll Cardiol. (1998)
^Lynch SM, et al. Formation of non-cyclooxygenase-derived prostanoids (F2-isoprostanes) in plasma and low density lipoprotein exposed to oxidative stress in vitro. J Clin Invest. (1994)
^Awad JA, et al. Detection and localization of lipid peroxidation in selenium- and vitamin E-deficient rats using F2-isoprostanes. J Nutr. (1994)
^Praticò D, et al. Vitamin E suppresses isoprostane generation in vivo and reduces atherosclerosis in ApoE-deficient mice. Nat Med. (1998)
^Bowry VW1, Ingold KU, Stocker R. Vitamin E in human low-density lipoprotein. When and how this antioxidant becomes a pro-oxidant. Biochem J. (1992)
^ a b Upston JM, Terentis AC, Stocker R. Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement. FASEB J. (1999)
^Santanam N1, Parthasarathy S. Paradoxical actions of antioxidants in the oxidation of low density lipoprotein by peroxidases. J Clin Invest. (1995)
^Upston JM1, Terentis AC, Stocker R. Tocopherol-mediated peroxidation of lipoproteins: implications for vitamin E as a potential antiatherogenic supplement. FASEB J. (1999)
^Stocker R. The ambivalence of vitamin E in atherogenesis. Trends Biochem Sci. (1999)
^Huie RE1, Padmaja S. The reaction of no with superoxide. Free Radic Res Commun. (1993)
^O'Donnell VB1, et al. Nitration of unsaturated fatty acids by nitric oxide-derived reactive nitrogen species peroxynitrite, nitrous acid, nitrogen dioxide, and nitronium ion. Chem Res Toxicol. (1999)
^Liu X1, et al. Accelerated reaction of nitric oxide with O2 within the hydrophobic interior of biological membranes. Proc Natl Acad Sci U S A. (1998)
^ a b c Hoglen NC1, et al. Reactions of peroxynitrite with gamma-tocopherol. Chem Res Toxicol. (1997)
^ a b c Christen S1, et al. gamma-tocopherol traps mutagenic electrophiles such as NO(X) and complements alpha-tocopherol: physiological implications. Proc Natl Acad Sci U S A. (1997)
^Radi R. Protein tyrosine nitration: biochemical mechanisms and structural basis of functional effects. Acc Chem Res. (2013)
^Goss SP1, Hogg N, Kalyanaraman B. The effect of alpha-tocopherol on the nitration of gamma-tocopherol by peroxynitrite. Arch Biochem Biophys. (1999)
^Wu JH1, et al. Nitration of gamma-tocopherol prevents its oxidative metabolism by HepG2 cells. Free Radic Biol Med. (2005)
^ a b Mangialasche F1, et al. Tocopherols and tocotrienols plasma levels are associated with cognitive impairment. Neurobiol Aging. (2012)
^Morton LW1, et al. Evidence for the nitration of gamma-tocopherol in vivo: 5-nitro-gamma-tocopherol is elevated in the plasma of subjects with coronary heart disease. Biochem J. (2002)
^Hensley K1, et al. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation. J Neurosci. (1998)
^Williamson KS1, et al. The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide. (2002)
^Morrow JD, Roberts LJ. The isoprostanes: unique bioactive products of lipid peroxidation. Prog Lipid Res. (1997)
^Mirbagheri SA1, et al. Rectal administration of d-alpha tocopherol for active ulcerative colitis: a preliminary report. World J Gastroenterol. (2008)
^Sumida Y1, et al. Involvement of free radicals and oxidative stress in NAFLD/NASH. Free Radic Res. (2013)
^Salt WB 2nd. Nonalcoholic fatty liver disease (NAFLD): a comprehensive review. J Insur Med. (2004)
^Erhardt A1, et al. Plasma levels of vitamin E and carotenoids are decreased in patients with Nonalcoholic Steatohepatitis (NASH). Eur J Med Res. (2011)
^Liu S1, et al. Plasma reactive carbonyl species levels and risk of non-alcoholic fatty liver disease. J Gastroenterol Hepatol. (2011)
^Matsuzawa N1, et al. Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet. Hepatology. (2007)
^Pacana T1, Sanyal AJ. Vitamin E and nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care. (2012)
^ a b c d Hasegawa T1, et al. Plasma transforming growth factor-beta1 level and efficacy of alpha-tocopherol in patients with non-alcoholic steatohepatitis: a pilot study. Aliment Pharmacol Ther. (2001)
^Kawanaka M, et al. Control of oxidative stress and reduction in biochemical markers by Vitamin E treatment in patients with nonalcoholic steatohepatitis: a pilot study. Hepatol Res. (2004)
^ a b c d Hoofnagle JH1, et al. Vitamin E and changes in serum alanine aminotransferase levels in patients with non-alcoholic steatohepatitis. Aliment Pharmacol Ther. (2013)
^Sumida Y, et al. Long-term (>=2 yr) efficacy of vitamin E for non-alcoholic steatohepatitis. Hepatogastroenterology. (2013)
^Sanyal AJ1, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med. (2010)
^Elias MC1, et al. Effect of 6-month nutritional intervention on non-alcoholic fatty liver disease. Nutrition. (2010)
^Bolton-Smith C1, et al. Antioxidant vitamin intakes assessed using a food-frequency questionnaire: correlation with biochemical status in smokers and non-smokers. Br J Nutr. (1991)
^Mezzetti A1, et al. Vitamins E, C and lipid peroxidation in plasma and arterial tissue of smokers and non-smokers. Atherosclerosis. (1995)
^Ross MA1, et al. Plasma concentrations of carotenoids and antioxidant vitamins in Scottish males: influences of smoking. Eur J Clin Nutr. (1995)
^ a b Dietrich M1, et al. Smoking and exposure to environmental tobacco smoke decrease some plasma antioxidants and increase gamma-tocopherol in vivo after adjustment for dietary antioxidant intakes. Am J Clin Nutr. (2003)
^ a b c d e Bruno RS1, et al. Faster plasma vitamin E disappearance in smokers is normalized by vitamin C supplementation. Free Radic Biol Med. (2006)
^ a b Bruno RS1, et al. {alpha}-Tocopherol disappearance is faster in cigarette smokers and is inversely related to their ascorbic acid status. Am J Clin Nutr. (2005)
^Handelman GJ1, Packer L, Cross CE. Destruction of tocopherols, carotenoids, and retinol in human plasma by cigarette smoke. Am J Clin Nutr. (1996)
^Leonard SW1, et al. 5-nitro-gamma-tocopherol increases in human plasma exposed to cigarette smoke in vitro and in vivo. Free Radic Biol Med. (2003)
^Bruno RS1, Traber MG. Cigarette smoke alters human vitamin E requirements. J Nutr. (2005)
^ a b McNamara M, Augusteyn RC. The effects of hydrogen peroxide on lens proteins: a possible model for nuclear cataract. Exp Eye Res. (1984)
^Varma SD, Srivastava VK, Richards RD. Photoperoxidation in lens and cataract formation: preventive role of superoxide dismutase, catalase and vitamin C. Ophthalmic Res. (1982)
^Hiller R, et al. Cigarette smoking and the risk of development of lens opacities. The Framingham studies. Arch Ophthalmol. (1997)
^Skalka HW, Prchal JT. Effect of corticosteroids on cataract formation. Arch Ophthalmol. (1980)
^Dickerson JE Jr, Dotzel E, Clark AF. Steroid-induced cataract: new perspective from in vitro and lens culture studies. Exp Eye Res. (1997)
^ a b c Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. (2001)
^Pastor-Valero M. Fruit and vegetable intake and vitamins C and E are associated with a reduced prevalence of cataract in a Spanish Mediterranean population. BMC Ophthalmol. (2013)
^ a b McNeil JJ, et al. Vitamin E supplementation and cataract: randomized controlled trial. Ophthalmology. (2004)
^Christen WG, et al. Age-related cataract in a randomized trial of vitamins E and C in men. Arch Ophthalmol. (2010)
^Christen WG, et al. Vitamins E and C and medical record-confirmed age-related macular degeneration in a randomized trial of male physicians. Ophthalmology. (2012)
^Christen W, et al. Age-related cataract in a randomized trial of beta-carotene in women. Ophthalmic Epidemiol. (2004)
^Christen WG, et al. A randomized trial of beta carotene and age-related cataract in US physicians. Arch Ophthalmol. (2003)
^Aydilek N, Aksakal M, Karakilçik AZ. Effects of testosterone and vitamin E on the antioxidant system in rabbit testis. Andrologia. (2004)
^Virtamo J, et al. Incidence of cancer and mortality following alpha-tocopherol and beta-carotene supplementation: a postintervention follow-up. JAMA. (2003)
^Blot WJ, et al. Nutrition Intervention Trials in Linxian, China: Supplementation With Specific Vitamin/Mineral Combinations, Cancer Incidence, and Disease-Specific Mortality in the General Population. J Natl Cancer Inst. (1993)
^ a b Zhang W, et al. Vitamin intake and liver cancer risk: a report from two cohort studies in china. J Natl Cancer Inst. (2012)
^Vlajinac HD1, et al. Diet and prostate cancer: a case-control study. Eur J Cancer. (1997)
^Tzonou A1, et al. Diet and cancer of the prostate: a case-control study in Greece. Int J Cancer. (1999)
^Key TJ1, et al. A case-control study of diet and prostate cancer. Br J Cancer. (1997)
^Rohan TE1, et al. Dietary factors and risk of prostate cancer: a case-control study in Ontario, Canada. Cancer Causes Control. (1995)
^ a b Huang HY1, et al. Prospective study of antioxidant micronutrients in the blood and the risk of developing prostate cancer. Am J Epidemiol. (2003)
^Knekt P1, et al. Serum vitamin E and risk of cancer among Finnish men during a 10-year follow-up. Am J Epidemiol. (1988)
^Weinstein SJ1, et al. Serum alpha-tocopherol and gamma-tocopherol in relation to prostate cancer risk in a prospective study. J Natl Cancer Inst. (2005)
^Heinonen OP1, et al. Prostate cancer and supplementation with alpha-tocopherol and beta-carotene: incidence and mortality in a controlled trial. J Natl Cancer Inst. (1998)
^ a b Weinstein SJ1, et al. Serum and dietary vitamin E in relation to prostate cancer risk. Cancer Epidemiol Biomarkers Prev. (2007)
^Huncharek M1, et al. Smoking as a risk factor for prostate cancer: a meta-analysis of 24 prospective cohort studies. Am J Public Health. (2010)
^Eichholzer M1, et al. Prediction of male cancer mortality by plasma levels of interacting vitamins: 17-year follow-up of the prospective Basel study. Int J Cancer. (1996)
^Gann PH1, et al. Lower prostate cancer risk in men with elevated plasma lycopene levels: results of a prospective analysis. Cancer Res. (1999)
^ a b Lippman SM1, et al. Effect of selenium and vitamin E on risk of prostate cancer and other cancers: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. (2009)
^ a b Klein EA1, et al. Vitamin E and the risk of prostate cancer: the Selenium and Vitamin E Cancer Prevention Trial (SELECT). JAMA. (2011)
^Kristal AR1, et al. Baseline Selenium Status and Effects of Selenium and Vitamin E Supplementation on Prostate Cancer Risk. J Natl Cancer Inst. (2014)
^Singh A1, et al. Dysfunctional KEAP1-NRF2 interaction in non-small-cell lung cancer. PLoS Med. (2006)
^Cancer Genome Atlas Research Network1. Comprehensive genomic characterization of squamous cell lung cancers. Nature. (2012)
^Singh A1, et al. RNAi-mediated silencing of nuclear factor erythroid-2-related factor 2 gene expression in non-small cell lung cancer inhibits tumor growth and increases efficacy of chemotherapy. Cancer Res. (2008)
^DeNicola GM1, et al. Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis. Nature. (2011)
^ a b Sayin VI1, et al. Antioxidants accelerate lung cancer progression in mice. Sci Transl Med. (2014)
^ a b c d Miller ER 3rd, et al. Meta-analysis: high-dosage vitamin E supplementation may increase all-cause mortality. Ann Intern Med. (2005)
^Greenberg ER, et al. A clinical trial of antioxidant vitamins to prevent colorectal adenoma. Polyp Prevention Study Group. N Engl J Med. (1994)
^Chylack LT Jr, et al. The Roche European American Cataract Trial (REACT): a randomized clinical trial to investigate the efficacy of an oral antioxidant micronutrient mixture to slow progression of age-related cataract. Ophthalmic Epidemiol. (2002)
^Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet. (2002)
^Boaz M, et al. Secondary prevention with antioxidants of cardiovascular disease in endstage renal disease (SPACE): randomised placebo-controlled trial. Lancet. (2000)
^ a b Sano M, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease. The Alzheimer's Disease Cooperative Study. N Engl J Med. (1997)
^[No authors listed. Mortality in DATATOP: a multicenter trial in early Parkinson's disease. Parkinson Study Group. Ann Neurol. (1998)
^[No authors listed. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics, and compliance. The ATBC Cancer Prevention Study Group. Ann Epidemiol. (1994)
^Packer JE, Slater TF, Willson RL. Direct observation of a free radical interaction between vitamin E and vitamin C. Nature. (1979)
^Tanaka K1, et al. Interactions between vitamin C and vitamin E are observed in tissues of inherently scorbutic rats. J Nutr. (1997)
^Hill KE1, et al. Combined deficiency of vitamins E and C causes paralysis and death in guinea pigs. Am J Clin Nutr. (2003)
^ a b Hemilä H1, Kaprio J. Modification of the effect of vitamin E supplementation on the mortality of male smokers by age and dietary vitamin C. Am J Epidemiol. (2009)
^ a b Thiele JJ, et al. Ozone-exposure depletes vitamin E and induces lipid peroxidation in murine stratum corneum. J Invest Dermatol. (1997)
^Thiele JJ, et al. In vivo exposure to ozone depletes vitamins C and E and induces lipid peroxidation in epidermal layers of murine skin. Free Radic Biol Med. (1997)
^ a b c d e Thiele JJ, Traber MG, Packer L. Depletion of human stratum corneum vitamin E: an early and sensitive in vivo marker of UV induced photo-oxidation. J Invest Dermatol. (1998)
^Thiele JJ, et al. Macromolecular carbonyls in human stratum corneum: a biomarker for environmental oxidant exposure. FEBS Lett. (1998)
^Beehler BC, et al. Formation of 8-hydroxydeoxyguanosine within DNA of mouse keratinocytes exposed in culture to UVB and H2O2. Carcinogenesis. (1992)
^McVean M, Liebler DC. Inhibition of UVB induced DNA photodamage in mouse epidermis by topically applied alpha-tocopherol. Carcinogenesis. (1997)
^ a b c d Shindo Y, et al. Enzymic and non-enzymic antioxidants in epidermis and dermis of human skin. J Invest Dermatol. (1994)
^Shindo Y, Witt E, Packer L. Antioxidant defense mechanisms in murine epidermis and dermis and their responses to ultraviolet light. J Invest Dermatol. (1993)
^Thiele JJ, Weber SU, Packer L. Sebaceous gland secretion is a major physiologic route of vitamin E delivery to skin. J Invest Dermatol. (1999)
^Weber SU1, et al. Vitamin C, uric acid, and glutathione gradients in murine stratum corneum and their susceptibility to ozone exposure. J Invest Dermatol. (1999)
^Thiele JJ1, Ekanayake-Mudiyanselage S. Vitamin E in human skin: organ-specific physiology and considerations for its use in dermatology. Mol Aspects Med. (2007)
^Enami S1, Hoffmann MR, Colussi AJ. How phenol and alpha-tocopherol react with ambient ozone at gas/liquid interfaces. J Phys Chem A. (2009)
^Tanaka H1, et al. The effect of reactive oxygen species on the biosynthesis of collagen and glycosaminoglycans in cultured human dermal fibroblasts. Arch Dermatol Res. (1993)
^Zaw KK1, et al. Catalase restores the altered mRNA expression of collagen and matrix metalloproteinases by dermal fibroblasts exposed to reactive oxygen species. Eur J Dermatol. (2006)
^Musalmah M1, et al. Effect of vitamin E on plasma malondialdehyde, antioxidant enzyme levels and the rates of wound closures during wound healing in normal and diabetic rats. Asia Pac J Clin Nutr. (2002)
^Suzuki YJ1, et al. Structural and dynamic membrane properties of alpha-tocopherol and alpha-tocotrienol: implication to the molecular mechanism of their antioxidant potency. Biochemistry. (1993)
^Musalmah M1, et al. Comparative effects of palm vitamin E and alpha-tocopherol on healing and wound tissue antioxidant enzyme levels in diabetic rats. Lipids. (2005)
^ a b Serbinova E1, et al. Free radical recycling and intramembrane mobility in the antioxidant properties of alpha-tocopherol and alpha-tocotrienol. Free Radic Biol Med. (1991)
^ a b c Baumann LS1, Spencer J. The effects of topical vitamin E on the cosmetic appearance of scars. Dermatol Surg. (1999)
^ a b Jenkins M1, et al. Failure of topical steroids and vitamin E to reduce postoperative scar formation following reconstructive surgery. J Burn Care Rehabil. (1986)
^Quinn KJ, et al. Non-pressure treatment of hypertrophic scars. Burns Incl Therm Inj. (1985)
^Palmieri B1, Gozzi G, Palmieri G. Vitamin E added silicone gel sheets for treatment of hypertrophic scars and keloids. Int J Dermatol. (1995)
^Naziroglu M1, Kokcam I. Antioxidants and lipid peroxidation status in the blood of patients with alopecia. Cell Biochem Funct. (2000)
^ a b Beoy LA1, Woei WJ2, Hay YK1. Effects of tocotrienol supplementation on hair growth in human volunteers. Trop Life Sci Res. (2010)
^Pulkkinen MO. Prostaglandins and the non-pregnant uterus. The pathophysiology of primary dysmenorrhea. Acta Obstet Gynecol Scand Suppl. (1983)
^el Attar TM1, Lin HS. Effect of vitamin C and vitamin E on prostaglandin synthesis by fibroblasts and squamous carcinoma cells. Prostaglandins Leukot Essent Fatty Acids. (1992)
^ a b Ziaei S1, et al. A randomised placebo-controlled trial to determine the effect of vitamin E in treatment of primary dysmenorrhoea. BJOG. (2001)
^ a b c Ziaei S1, Zakeri M, Kazemnejad A. A randomised controlled trial of vitamin E in the treatment of primary dysmenorrhoea. BJOG. (2005)
^ a b Kashanian M1, et al. Evaluation of the effect of vitamin E on pelvic pain reduction in women suffering from primary dysmenorrhea. J Reprod Med. (2013)
^Perry G, Cash AD, Smith MA. Alzheimer Disease and Oxidative Stress. J Biomed Biotechnol. (2002)
^Yoshida S, et al. Postischemic cerebral lipid peroxidation in vitro: modification by dietary vitamin E. J Neurochem. (1985)
^Behl C, et al. Vitamin E protects nerve cells from amyloid beta protein toxicity. Biochem Biophys Res Commun. (1992)
^Mangialasche F1, et al. Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults. Exp Gerontol. (2013)
^ a b Dysken MW1, et al. Effect of vitamin E and memantine on functional decline in Alzheimer disease: the TEAM-AD VA cooperative randomized trial. JAMA. (2014)
^Evans DA1, Morris MC2, Rajan KB1. Vitamin E, memantine, and Alzheimer disease. JAMA. (2014)
^ a b Petersen RC1, et al. Vitamin E and donepezil for the treatment of mild cognitive impairment. N Engl J Med. (2005)
^Etminan M1, Gill SS, Samii A. Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis. Lancet Neurol. (2005)
^Adams JD Jr1, et al. Alzheimer's and Parkinson's disease. Brain levels of glutathione, glutathione disulfide, and vitamin E. Mol Chem Neuropathol. (1991)
^Yun JS1, et al. Protective effects of Vitamin E on endocrine disruptors, PCB-induced dopaminergic neurotoxicity. Toxicology. (2005)
^Ren YR1, et al. Genetic vitamin E deficiency does not affect MPTP susceptibility in the mouse brain. J Neurochem. (2006)
^Sherer TB1, et al. Mechanism of toxicity in rotenone models of Parkinson's disease. J Neurosci. (2003)
^Sharma N1, Nehru B. Beneficial Effect of Vitamin E in Rotenone Induced Model of PD: Behavioural, Neurochemical and Biochemical Study. Exp Neurobiol. (2013)
^Parkinson Study Group. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. N Engl J Med. (1993)
^ a b Terro F1, et al. Antioxidant drugs block in vitro the neurotoxicity of CSF from patients with amyotrophic lateral sclerosis. Neuroreport. (1996)
^ a b Tohgi H1, et al. alpha-Tocopherol quinone level is remarkably low in the cerebrospinal fluid of patients with sporadic amyotrophic lateral sclerosis. Neurosci Lett. (1996)
^Iwasaki Y1, Ikeda K, Kinoshita M. Vitamin A and E levels are normal in amyotrophic lateral sclerosis. J Neurol Sci. (1995)
^Oteiza PI1, et al. Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients. Neurochem Res. (1997)
^Niki E. Tocopherylquinone and tocopherylhydroquinone. Redox Rep. (2007)
^Neuzil J1, Witting PK, Stocker R. Alpha-tocopheryl hydroquinone is an efficient multifunctional inhibitor of radical-initiated oxidation of low density lipoprotein lipids. Proc Natl Acad Sci U S A. (1997)
^Bindoli A, Valente M, Cavallini L. Inhibition of lipid peroxidation by alpha-tocopherolquinone and alpha-tocopherolhydroquinone. Biochem Int. (1985)
^Palan PR1, et al. Alpha-tocopherol and alpha-tocopheryl quinone levels in cervical intraepithelial neoplasia and cervical cancer. Am J Obstet Gynecol. (2004)
^Mottier P1, et al. Comparison of gas chromatography-mass spectrometry and liquid chromatography-tandem mass spectrometry methods to quantify alpha-tocopherol and alpha-tocopherolquinone levels in human plasma. Anal Biochem. (2002)
^Pollok D1, Melchert HU. Determination of alpha-tocopherolquinone in human serum samples by liquid chromatography with fluorescence detection and on-line post-column derivatization. J Chromatogr A. (2004)
^ a b Michal Freedman D, et al. Vitamin E serum levels and controlled supplementation and risk of amyotrophic lateral sclerosis. Amyotroph Lateral Scler Frontotemporal Degener. (2013)
^Wang H1, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies. Am J Epidemiol. (2011)
^Arita M1, et al. Human alpha-tocopherol transfer protein: cDNA cloning, expression and chromosomal localization. Biochem J. (1995)
^Hentati A1, et al. Human alpha-tocopherol transfer protein: gene structure and mutations in familial vitamin E deficiency. Ann Neurol. (1996)
^Catignani GL. An alpha-tocopherol binding protein in rat liver cytoplasm. Biochem Biophys Res Commun. (1975)
^Mowri H, et al. Enhancement of the transfer of alpha-tocopherol between liposomes and mitochondria by rat-liver protein(s). Eur J Biochem. (1981)
^Murphy DJ, Mavis RD. Membrane transfer of alpha-tocopherol. Influence of soluble alpha-tocopherol-binding factors from the liver, lung, heart, and brain of the rat. J Biol Chem. (1981)
^ a b Aparicio JM1, et al. Ataxia with isolated vitamin E deficiency: case report and review of the literature. J Pediatr Gastroenterol Nutr. (2001)
^Gordon N. Hereditary vitamin-E deficiency. Dev Med Child Neurol. (2001)
^Mariotti C1, et al. Ataxia with isolated vitamin E deficiency: neurological phenotype, clinical follow-up and novel mutations in TTPA gene in Italian families. Neurol Sci. (2004)
^ a b Doria-Lamba L1, et al. Efficacious vitamin E treatment in a child with ataxia with isolated vitamin E deficiency. Eur J Pediatr. (2006)
^Rael LT1, et al. Lipid peroxidation and the thiobarbituric acid assay: standardization of the assay when using saturated and unsaturated fatty acids. J Biochem Mol Biol. (2004)
^Gutteridge JM. Aspects to consider when detecting and measuring lipid peroxidation. Free Radic Res Commun. (1986)
^Song JH1, Fujimoto K, Miyazawa T. Polyunsaturated (n-3) fatty acids susceptible to peroxidation are increased in plasma and tissue lipids of rats fed docosahexaenoic acid-containing oils. J Nutr. (2000)
^Kobatake Y, et al. Dietary effect of omega-3 type polyunsaturated fatty acids on serum and liver lipid levels in rats. J Nutr Sci Vitaminol (Tokyo). (1983)
^Kubo K1, et al. Dietary docosahexaenoic acid dose not promote lipid peroxidation in rat tissue to the extent expected from peroxidizability index of the lipids. Biosci Biotechnol Biochem. (1998)
^Kubo K1, et al. Changes in susceptibility of tissues to lipid peroxidation after ingestion of various levels of docosahexaenoic acid and vitamin E. Br J Nutr. (1997)
^Kubo K1, et al. Preferential incorporation of docosahexaenoic acid into nonphosphorus lipids and phosphatidylethanolamine protects rats from dietary DHA-stimulated lipid peroxidation. J Nutr. (2000)
^Muggli R. Physiological requirements of vitamin E as a function of the amount and type of polyunsaturated fatty acid. World Rev Nutr Diet. (1994)
^ a b c Valk EE1, Hornstra G. Relationship between vitamin E requirement and polyunsaturated fatty acid intake in man: a review. Int J Vitam Nutr Res. (2000)
^Saito M1, Kubo K. Relationship between tissue lipid peroxidation and peroxidizability index after alpha-linolenic, eicosapentaenoic, or docosahexaenoic acid intake in rats. Br J Nutr. (2003)
^ a b Sontag TJ1, Parker RS. Cytochrome P450 omega-hydroxylase pathway of tocopherol catabolism. Novel mechanism of regulation of vitamin E status. J Biol Chem. (2002)
^Kamal-Eldin A, et al. Effects of dietary phenolic compounds on tocopherol, cholesterol, and fatty acids in rats. Lipids. (2000)
^Kamal-Eldin A, Pettersson D, Appelqvist LA. Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. Lipids. (1995)
^Baxter LL, et al. Plasma and tissue concentrations of α-tocopherol and δ-tocopherol following high dose dietary supplementation in mice. Nutrients. (2012)
^Rogi T, et al. The mechanism underlying the synergetic hypocholesterolemic effect of sesamin and α-tocopherol in rats fed a high-cholesterol diet. J Pharmacol Sci. (2011)
^Frank J, et al. Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr. (2008)
^Carini M1, et al. UVB-induced hemolysis of rat erythrocytes: protective effect of procyanidins from grape seeds. Life Sci. (2000)
^Maffei Facino R1, et al. Sparing effect of procyanidins from Vitis vinifera on vitamin E: in vitro studies. Planta Med. (1998)
^Carini M1, et al. The protection of polyunsaturated fatty acids in micellar systems against UVB-induced photo-oxidation by procyanidins from Vitis vinifera L., and the protective synergy with vitamin E. Int J Cosmet Sci. (1998)
^Burton GW, et al. Vitamin E as an antioxidant in vitro and in vivo. Ciba Found Symp. (1983)
^Ursini F, Maiorino M, Gregolin C. The selenoenzyme phospholipid hydroperoxide glutathione peroxidase. Biochim Biophys Acta. (1985)
^Maiorino M, et al. Microsomal lipid peroxidation: effect of vitamin E and its functional interaction with phospholipid hydroperoxide glutathione peroxidase. Lipids. (1989)
^Tramer F, et al. Antioxidant Systems in Rat Epididymal Spermatozoa. Biol Reprod. (1998)
^Lesser GJ, et al. A randomized, double-blind, placebo-controlled study of oral coenzyme Q10 to relieve self-reported treatment-related fatigue in newly diagnosed patients with breast cancer. J Support Oncol. (2013)
^Fontana L, et al. CoQ10 blood levels and erythrocyte concentration of GSH in ischemic heart patients during exercise test (effects of vitamin E). Minerva Cardioangiol. (1995)
^Coombes JS, et al. Effect of combined supplementation with vitamin E and alpha-lipoic acid on myocardial performance during in vivo ischaemia-reperfusion. Acta Physiol Scand. (2000)
^González-Pérez O, Moy-López NA, Guzmán-Muñiz J. Alpha-tocopherol and alpha-lipoic acid. An antioxidant synergy with potential for preventive medicine. Rev Invest Clin. (2008)
^Corrigan JJ Jr, Marcus FI. Coagulopathy associated with vitamin E ingestion. JAMA. (1974)
^Yue QY, Jansson K. Herbal drug curbicin and anticoagulant effect with and without warfarin: possibly related to the vitamin E component. J Am Geriatr Soc. (2001)
^Bakhshi S1, et al. Prevention of subclinical vitamin K deficiency based on PIVKA-II levels: oral versus intramuscular route. Indian Pediatr. (1996)
^Booth SL1, et al. Effect of vitamin E supplementation on vitamin K status in adults with normal coagulation status. Am J Clin Nutr. (2004)
^Ziouzenkova O1, et al. Lack of correlation between the alpha-tocopherol content of plasma and LDL, but high correlations for gamma-tocopherol and carotenoids. J Lipid Res. (1996)
^Perugini C1, et al. Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. I. Correlation with plasma antioxidant levels and composition of lipoproteins. Pharmacol Res. (2000)
^Perugini C1, et al. Distribution of lipid-soluble antioxidants in lipoproteins from healthy subjects. II. Effects of in vivo supplementation with alpha-tocopherol. Pharmacol Res. (2000)
^Fuhrman B1, et al. Lycopene synergistically inhibits LDL oxidation in combination with vitamin E, glabridin, rosmarinic acid, carnosic acid, or garlic. Antioxid Redox Signal. (2000)
^Berry D, Wathen JK, Newell M. Bayesian model averaging in meta-analysis: vitamin E supplementation and mortality. Clin Trials. (2009)
^Gerss J, Köpcke W. The questionable association of vitamin E supplementation and mortality--inconsistent results of different meta-analytic approaches. Cell Mol Biol (Noisy-le-grand). (2009)
^Greenland S. Weaknesses of Bayesian model averaging for meta-analysis in the study of vitamin E and mortality. Clin Trials. (2009)
^Miller ER 3rd, Guallar E. Vitamin E supplementation: what's the harm in that. Clin Trials. (2009)
^Dotan Y, Lichtenberg D, Pinchuk I. No evidence supports vitamin E indiscriminate supplementation. Biofactors. (2009)
^Wada S. Chemoprevention of tocotrienols: the mechanism of antiproliferative effects. Forum Nutr. (2009)
^Hunter D1, Frumkin A. Adverse reactions to vitamin E and aloe vera preparations after dermabrasion and chemical peel. Cutis. (1991)
^ a b Perrenoud D1, et al. An epidemic outbreak of papular and follicular contact dermatitis to tocopheryl linoleate in cosmetics. Swiss Contact Dermatitis Research Group. Dermatology. (1994)
Roberts LJ 2nd, et al. The relationship between dose of vitamin E and suppression of oxidative stress in humans. Free Radic Biol Med. (2007)
Meagher EA, et al. Effects of vitamin E on lipid peroxidation in healthy persons. JAMA. (2001)
Dadkhah H, Ebrahimi E, Fathizadeh N. Evaluating the effects of vitamin D and vitamin E supplement on premenstrual syndrome: A randomized, double-blind, controlled trial. Iran J Nurs Midwifery Res. (2016)
London RS, et al. The effect of alpha-tocopherol on premenstrual symptomatology: a double-blind study. II. Endocrine correlates. J Am Coll Nutr. (1984)
Shobeiri F, Oshvandi K, Nazari M. Clinical effectiveness of vitamin E and vitamin B6 for improving pain severity in cyclic mastalgia. Iran J Nurs Midwifery Res. (2015)
Parsay S, Olfati F, Nahidi S. Therapeutic effects of vitamin E on cyclic mastalgia. Breast J. (2009)