Lysine is an amino acid (building block of protein). People use it to make medicine.

Lysine is used for preventing and treating cold sores (caused by the virus called herpes simplex labialis). It is taken by mouth or applied directly to the skin for this use.

Lysine is also taken by mouth to improve athletic performance.


Is a Form of:

Amino Acid

Primary Functions:

Preventing and Treating Cold Sores

Also Known As:

 L-Lysine, L-Lysine HCl, L-Lysine Hydrochloride, L-Lysine Monohydrochloride

How Does It Work?

Lysine seems to prevent the herpes virus from growing.


  • Cold sores (herpes simplex labialis).Research suggests that lysine seems to reduce cold sores when taken by mouth and also when applied as a cream to the skin. However, some research suggests that it does not reduce the severity or recurrence of cold sores.

Recommended Dosing

The following doses have been studied in scientific research:


  • For cold sores (herpes simplex labialis): 1000 mg daily for 12 months and 1000 mg three times daily for 6 months.


  • For treating cold sores (herpes simplex labialis): a specific combination of lysine plus zinc oxide and 14 other ingredients (Super Lysine Plus +) applied every 2 hours for 11 days has been used.

Lysine Supplements Frequently Asked Questions

What are the benefits of taking lysine?

  • May Protect Against and Treat Cold Sores by Blocking Arginine
  • May Reduce Anxiety by Blocking Stress Response Receptors
  • May Improve Calcium Absorption and Retention
  • Can Promote Wound Healing by Helping Create Collagen
  • Top Food Sources and Supplements.

Is it safe to take lysine supplements?

Lysine is POSSIBLY SAFE for most people when taken by mouth at recommended doses for up to one year, or when applied to the skin short-term. It can cause side effects such as stomach pain and diarrhea.

How much lysine should I take?

The recommended dosage of L lysine is 500mg 2-3 times daily. In conjunction with taking Lysine, you should avoid a diet high in Arginine containing foods such as chocolate, nuts and dairy. High Arginine diets can make herpes worse.

Does L Lysine kill viruses?

L-Lysine: L-lysine plays a particularly important role in the immune system. It is involved in the development of antibodies and has important antiviral properties. L-Lysine inhibits the proliferation of viruses and strengthens the body's connective tissue, providing a barrier against bacteria and viruses.

Does lysine kill viruses?

Lysine Is An Amino Acid That Seems To Inhibit Virus.

And antibiotics don't work on virus, and will only make matters worse as the natural healthy gut flora is killed off and makes you even more vulnerable to viral infections ongoing.

Can you take lysine everyday?

Lysine is available as an oral supplement and a cream. To treat a cold sore infection, apply lysine cream to the affected area every two hours for 11 days. To manage cold sore infections, the recommended dosage for oral supplements is 1 gram three times daily. To help prevent them, the dosage is 1 gram daily.

Is lysine bad for your kidneys?

Lysine is a major constituent of amino acid parenteral nutrition solutions which have recently been shown to increase the severity of various types of acute renal failure in the rat. In previous studies the authors have shown that high-dose lysine alone is capable of causing acute renal failure.

What is the difference between lysine and L Lysine?

Lysine is a building block for protein. It's an essential amino acid because your body cannot make it, so you need to obtain it from food. L-lysine is the form of lysine your body can utilize. It's naturally found in food and is the type used in supplements.

Is 3000 mg of lysine too much?

While this study called for 3,000 mg of Lysine per day, in general, the studies that had subjects take a minimum of 1,000 mg per day had positive results. Individuals who suffer from canker sores or herpes outbreaks may find the supplement Lysine helpful in managing their condition.

Does lysine cause hair loss?

An L-lysine deficiency can cause hair loss, but getting enough of this amino acid can prevent this issue and promote regular hair growth. People can take L-lysine supplements.

Does Lysine improve skin?

It also helps your body better absorb calcium for bone health. Lysine may also treat cold sores. Studies show that Lysine helps build collagen in the skin. Getting adequate amounts of amino acids, including lysine, along with other healthy nutrients may contribute to overall skin health.

How long can you take lysine supplements?

Lysine is POSSIBLY SAFE for most people when taken by mouth at recommended doses for up to one year, or when applied to the skin short-term.

Are Bananas high in lysine?

While eating foods rich in lysine (such as bananas) has the theoretical capacity to help prevent cold sores, a more aggressive approach tends to work better in practice. Taking 1,000mg of lysine in supplement form each day often proves effective in reducing the risk of cold-sore outbreaks.

Is lysine good for your heart?

Lysine, like steel rods in concrete, makes collagen stronger. Pauling claimed it takes a mere 10 milligrams to prevent scurvy, but several thousand to prevent heart attack. Stehbens' research showed that coronary arteries closest to the heart are under the greatest pressure.

Can you take lysine long term?

Lysine is POSSIBLY SAFE for most people when taken by mouth at recommended doses for up to one year, or when applied to the skin short-term. It can cause side effects such as stomach pain and diarrhea.

Does lysine help flu?

People taking lysine had fewer infections, shorter infections and faster healing. Other studies have been conflicting, but lysine is certainly worth a try when it comes to fighting cold sores—or the common cold itself. xxiii Take: 1,000 mg three times a day at the first onset of symptoms.

Does L Lysine make you gain weight?

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What foods are high in lysine and low in arginine?

Fish, chicken, beef, lamb, milk, cheese, beans, brewer's yeast, mung bean sprouts and most fruits and vegetables have more lysine than arginine, except for peas. Gelatin, chocolate, carob, coconut, oats, whole wheat and, white flour, peanuts, soybeans, and wheat germ have more arginine than lysine.

Does lysine help with all viruses?

L-lysine doesn't just fight the Herpes Simplex virus that causes cold sores. It hinders and stops all herpetic family viruses, which is critical because this family of viruses are responsible for hundreds of different chronic symptoms and illnesses that millions of people across the globe are suffering with.

Is L Lysine good for immune system?

Lysine, one of the essential amino acids, has an important role in the immune system, including preventing recurrence of herpes simplex virus, reducing morbidity as a result of diarrhea and bronchopneumonia. Lysine can also increase absorption of zinc.

Is lysine good for shingles?

It's thought that L-lysine can help relieve cold sores. Herpes simplex virus type 1 (HSV-1) causes cold sores. The virus can then reemerge, usually years later, as shingles. While L-lysine is said to relieve cold sores, there's no evidence to support its treatment of shingles.

Is L Lysine an antiviral?

Lysine has antiviral effects by blocking the activity of arginine, which promotes HSV replication. One study found that taking lysine at the beginning of a herpes outbreak did not reduce symptoms. Most experts believe that lysine does not improve the healing of cold sores.

Is lysine bad for liver?

While lysine in the diet is considered safe, excessive doses may cause gallstones. There have also been reports of renal dysfunction, including Fanconi syndrome and renal failure. Talk to your doctor before taking supplemental lysine if you have kidney disease, liver disease, or if you are pregnant or breastfeeding.

Clinical Studies