Horse Chestnut
Overview
Horse chestnut is a tree. Its seed, bark, flower, and leaves are used to make medicine. Horse chestnut contains significant amounts of a poison called esculin and can cause death if eaten raw.
Be careful not to confuse Aesculus hippocastanum (Horse chestnut) with Aesculus californica (California buckeye) or Aesculus glabra (Ohio buckeye). Some people call any of these plants horse chestnut. This information applies to Aesculus hippocastanum only.
Horse chestnut seed extracts are most commonly taken by mouth to treat varicose veins and other circulatory problems that can cause the legs to swell. There is currently no good scientific research to support the use of horse chestnut for other conditions.
Classification
Is a Form of:
Tree
Primary Functions:
Varicose veins
Also Known As:
Aescin, Aescine, Aesculus hippocastanum, Buckeye
How Does It Work?
Horse chestnut contains a substance that thins the blood. It also makes it harder for fluid to leak out of veins and capillaries and weakly promotes fluid loss through the urine to help prevent water retention (edema).
Uses
- Poor circulation that can cause the legs to swell (chronic venous insufficiency or CVI).Taking 300 mg of standardized horse chestnut seed extract can reduce some symptoms of poor blood circulation, such as varicose veins, pain, tiredness, swelling in the legs, itching, and water retention. However, some early research suggests that horse chestnut might be less effective than maritime pine bark for reducing leg swelling and cramps.
Recommended Dosing
The following dose has been studied in scientific research:
BY MOUTH:
- For poor blood circulation (chronic venous insufficiency): 300 mg of horse chestnut seed extract containing 50 mg of the active ingredient, aescin, twice daily.
Horse Chestnut Supplements Frequently Asked Questions
How long does it take for horse chestnut to work?
It is best to use a horse chestnut product that contains an exact amount of the labeled chemical. Check the label to be sure your product does not contain a toxic substance called "esculin." It may take up to 4 weeks before your symptoms improve.
Is Horse Chestnut good for hair growth?
So from dry skin to hair growth, discover some of the most-talked and revered supplements available. High in Omega 3 fats, it helps to 'drench' the skin from inside-out. The one for varicose veins – Horse chestnut seed is well-known for reducing and controlling inflammation, the main cause of varicose veins.
Does horse chestnut affect blood pressure?
Horse chestnut extract appears to impair the action of platelets (important components of blood clotting). These effects result in reduced inflammation and reduced blood pressure. Horse chestnut also reduces swelling by constricting vessels of the venous system and slowing the leakage of fluid out of the veins.
What is horse chestnut pills good for?
Today, people use horse chestnut extract as a dietary supplement for chronic venous insufficiency (when the veins of the lower leg are unable to send blood back toward the heart), hemorrhoids, and swelling after surgery. Preparations made from the tree's bark are applied to skin sores.
What are the side effects of horse chestnut?
Horse chestnut products can sometimes cause side effects such as dizziness, headache, nausea, stomach upset, itching, and calf spasms. Pollen from the horse chestnut flower can cause allergic reactions. Rectal (suppository) use of horse chestnut may cause inflammation and itching in the anal area.
Is Horse Chestnut safe?
Properly processing horse chestnut seed extract removes esculin. The processed extract is considered generally safe when used for short periods of time. However, the extract can cause some side effects, including itching, nausea, gastrointestinal upset, muscle spasm, or headache.
Is horse chestnut extract safe to take?
Summary Horse chestnut seed extract is generally safe to take or use topically. However, there are some reported side effects, interactions with certain medications, and safety concerns associated with certain medical conditions.
Is Horse Chestnut good for skin?
Topical horse chestnut also can soothe varicose veins due to the escin content, which imparts anti-inflammatory and anti-edema activities on capillary permeability. The branch bark of horse chestnut is sometimes used on skin to treat lupus, skin ulcers and eczema.
Is Horse Chestnut good for varicose veins?
May treat varicose veins
Horse chestnut seed extract may improve venous tone by improving blood flow in your legs. Additionally, it may help decrease leg swelling and pain associated with varicose veins.
Is Horse Chestnut good for the heart?
Horse chestnut has been used in alternative medicine and is likely effective in treating some symptoms of chronic venous insufficiency (decreased blood flow return from the feet and legs back to the heart). Medicinal use of this product has not been approved by the FDA.
Is horse chestnut a diuretic?
Horse chestnut may reduce the absorption of NSAIDs, which are drugs used to treat inflammation. Lithium. Horse chestnut may have a diuretic effect, which could delay how fast your body processes lithium, a medication used to treat psychiatric disorders.
Why are they called horse chestnuts?
When the tree was brought to Britain in 1616 from the Balkans, it was called horse chestnut because the Turks would feed the seeds to their ailing horses. The tree is chiefly grown nowadays for ornamental purposes, in towns and private gardens and in parks, and along streets.
Does horse chestnut shrink hemorrhoids?
The anti-inflammatory properties of horse chestnut seed extract may help relieve symptoms of hemorrhoids by reducing inflammation and swelling in the affected veins. Summary Horse chestnut extract may help relieve hemorrhoid symptoms by reducing pain and swelling, but more research is needed.
What animal eats horse chestnuts?
Despite being called horse chestnuts, conkers can actually be mildly poisonous to some animals. Other animals, such as deer and wild boar, can safely consume them.
Can you cook horse chestnuts?
Don't do it! Even though conkers might look appealing, there's no sensible way you can eat one. And yes, that applies even if you fry, boil or roast them.
Are horse chestnuts poisonous to dogs?
Horse chestnut trees drop hard, dark brown nuts, or conkers, from September onwards. Just like the tree's bark, leaves and flowers, they can be fatal to dogs if ingested. Not only do they pose a choking risk due to their size and shape, they also contain a deadly toxin called Aesculin which is poisonous to pups.
Are conkers horse chestnuts?
Conkers are the glossy brown seeds of the horse chestnut tree. They grow in green spiky cases and fall to the ground in autumn - the shells often split on impact to reveal the shiny conker inside.
Are horse chestnuts poisonous to humans?
Raw horse chestnut seed, leaf, bark and flower are toxic due to the presence of esculin and should not be ingested. Horse chestnut seed is classified by the FDA as an unsafe herb. The glycoside and saponin constituents are considered toxic.
Why are horse chestnuts poisonous?
Raw horse chestnut seed, leaf, bark and flower are toxic due to the presence of esculin and should not be ingested. Horse chestnut seed is classified by the FDA as an unsafe herb. The glycoside and saponin constituents are considered toxic.
Can goats eat horse chestnuts?
Not so the horse chestnut, willow and sweet chestnut - all difficult to digest. But suitable for sheep and goats, which latter animal, The Dendrologist tells us, should never be fed on grass alone. And there are killer trees, or rather trees that make animals sick if they eat the leaves.
Clinical Studies
- ^ a b Siegers CP, Syed Ali S, Tegtmeier M. Aescin and troxerutin as a successful combination for the treatment of inner ear perfusion disturbances. Phytomedicine. (2008)
- ^ a b c d e f g h i j k l m n Sirtori CR. Aescin: pharmacology, pharmacokinetics and therapeutic profile. Pharmacol Res. (2001)
- ^ a b Dudek-Makuch M, Matławska I. Coumarins in horse chestnut flowers: isolation and quantification by UPLC method. Acta Pol Pharm. (2013)
- ^ a b c d e f g h i Zlatanov MD, et al. Lipid composition of Castanea sativa Mill. and Aesculus hippocastanum fruit oils. J Sci Food Agric. (2013)
- ^ a b c d [No authors listed. Aesculus hippocastanum (Horse chestnut). Monograph. Altern Med Rev. (2009)
- ^ a b c d e Kapusta I, et al. Flavonoids in horse chestnut (Aesculus hippocastanum) seeds and powdered waste water byproducts. J Agric Food Chem. (2007)
- ^ a b c Hübner G, Wray V, Nahrstedt A. Flavonol oligosaccharides from the seeds of Aesculus hippocastanum. Planta Med. (1999)
- ^ a b Dudek-Makuch M, Matławska I. Flavonoids from the flowers of Aesculus hippocastanum. Acta Pol Pharm. (2011)
- ^ a b Chemical investigation of the New England horse chestnut, aesculus hippocastanum.
- ^Â Analysis of sterol fractions from twenty vegetable oils.
- ^Â Composition of the sterol fraction in horse chestnut.
- ^ a b Lindner I, et al. Beta-escin has potent anti-allergic efficacy and reduces allergic airway inflammation. BMC Immunol. (2010)
- ^ Di Pierro F, et al. Clinical effectiveness of a highly standardized and bioavailable mixture of flavonoids and triterpenes in the management of acute hemorroidal crisis. Acta Biomed. (2011)
- ^ Lang W, Mennicke WH. Pharmacokinetic studies on triatiated aescin in the mouse and rat. Arzneimittelforschung. (1972)
- ^ a b c d Wu XJ, et al. Comparative pharmacokinetics and bioavailability of escin Ia and isoescin Ia after administration of escin and of pure escin Ia and isoescin Ia in rat. J Ethnopharmacol. (2012)
- ^ a b c Bässler D, et al. Bioavailability of beta-aescin from horse chestnut seed extract: comparative clinical studies of two Galenic formulations. Adv Ther. (2003)
- ^ Loew D, et al. Measurement of the bioavailability of aescin-containing extracts. Methods Find Exp Clin Pharmacol. (2000)
- ^ Yang XW, et al. Studies on the biotransformation of escin Ia by human intestinal bacteria and the anti-tumor activities of desacylescin I. Beijing Da Xue Xue Bao. (2004)
- ^ Charles SM, et al. Roles of cytosolic Ca2+ concentration and myofilament Ca2+ sensitization in age-dependent cerebrovascular myogenic tone. Am J Physiol Heart Circ Physiol. (2010)
- ^ a b Savineau JP, Marthan R. Activation properties of chemically skinned fibres from human isolated bronchial smooth muscle. J Physiol. (1994)
- ^ Fernandez SF, et al. Mechanisms of angiotensin II-mediated decreases in intraneuronal Ca2+ in calcium-loaded stellate ganglion neurons. Hypertension. (2005)
- ^ Ikemoto T, Iino M, Endo M. Enhancing effect of calmodulin on Ca(2+)-induced Ca2+ release in the sarcoplasmic reticulum of rabbit skeletal muscle fibres. J Physiol. (1995)
- ^ Launikonis BS, Stephenson DG. Effects of beta-escin and saponin on the transverse-tubular system and sarcoplasmic reticulum membranes of rat and toad skeletal muscle. Pflugers Arch. (1999)
- ^ a b Arnould T, et al. Effect of aescine on hypoxia-induced activation of human endothelial cells. Eur J Pharmacol. (1996)
- ^ Bougelet C, et al. Effect of aescine on hypoxia-induced neutrophil adherence to umbilical vein endothelium. Eur J Pharmacol. (1998)
- ^ a b c d e Carrasco OF, Vidrio H. Endothelium protectant and contractile effects of the antivaricose principle escin in rat aorta. Vascul Pharmacol. (2007)
- ^ Moncada S, Palmer RM, Gryglewski RJ. Mechanism of action of some inhibitors of endothelium-derived relaxing factor. Proc Natl Acad Sci U S A. (1986)
- ^ a b Pierrakos CN, et al. Effects of l-NAME on coronary blood flow, infarct size and the extent of the no-reflow phenomenon. Int J Cardiol. (2012)
- ^ a b Guillaume M, Padioleau F. Veinotonic effect, vascular protection, antiinflammatory and free radical scavenging properties of horse chestnut extract. Arzneimittelforschung. (1994)
- ^ Alderton WK, Cooper CE, Knowles RG. Nitric oxide synthases: structure, function and inhibition. Biochem J. (2001)
- ^ a b Berti F, Omini C, Longiave D. The mode of action of aescin and the release of prostaglandins. Prostaglandins. (1977)
- ^ a b Annoni F, et al. Venotonic activity of escin on the human saphenous vein. Arzneimittelforschung. (1979)
- ^ a b Responsiveness of human varicose saphenous veins to vasoactive agents.
- ^ Longiave D, et al. The mode of action of aescin on isolated veins: relationship with PGF2 alpha. Pharmacol Res Commun. (1978)
- ^ Smith PC. The causes of skin damage and leg ulceration in chronic venous disease. Int J Low Extrem Wounds. (2006)
- ^ Beebe-Dimmer JL, et al. The epidemiology of chronic venous insufficiency and varicose veins. Ann Epidemiol. (2005)
- ^ Partsch H. Varicose veins and chronic venous insufficiency. Vasa. (2009)
- ^ Diehm C, et al. Medical edema protection--clinical benefit in patients with chronic deep vein incompetence. A placebo controlled double blind study. Vasa. (1992)
- ^ a b Diehm C, et al. Comparison of leg compression stocking and oral horse-chestnut seed extract therapy in patients with chronic venous insufficiency. Lancet. (1996)
- ^ Friederich HC, Vogelsberg H, Neiss A. Evaluation of internally effective venous drugs. Z Hautkr. (1978)
- ^ Neiss A, Böhm C. Demonstration of the effectiveness of the horse-chestnut-seed extract in the varicose syndrome complex. MMW Munch Med Wochenschr. (1976)
- ^ a b c d e Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. (2006)
- ^ Partsch H. Compression therapy of the legs. A review. J Dermatol Surg Oncol. (1991)
- ^ Belcaro G, et al. O-(beta-hydroxyethyl)-rutosides systemic and local treatment in chronic venous disease and microangiopathy: an independent prospective comparative study. Angiology. (2008)
- ^ Wadworth AN, Faulds D. Hydroxyethylrutosides. A review of its pharmacology, and therapeutic efficacy in venous insufficiency and related disorders. Drugs. (1992)
- ^ Hiai S, Yokoyama H, Oura H. Effect of escin on adrenocorticotropin and corticosterone levels in rat plasma. Chem Pharm Bull (Tokyo). (1981)
- ^Â Escin may exert a synergistic anti-inflammatory effect with glucocorticoids.
- ^ Xiao GM, Wei J. Effects of beta-Aescin on the expression of nuclear factor-kappaB and tumor necrosis factor-alpha after traumatic brain injury in rats. J Zhejiang Univ Sci B. (2005)
- ^ Hu XM, Zhang Y, Zeng FD. Effects of sodium beta-aescin on expression of adhesion molecules and migration of neutrophils after middle cerebral artery occlusion in rats. Acta Pharmacol Sin. (2004)
- ^Â Cytoplasmic phospholipase A2 activity and gene expression are stimulated by tumor necrosis factor: dexamethasone blocks the induced synthesis.
- ^ Auphan N, et al. Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. Science. (1995)
- ^Â A mechanism for the antiinflammatory effects of corticosteroids: The glucocorticoid receptor regulates leukocyte adhesion to endothelial cells and expression of endothelial-leukocyte adhesion molecule 1 and intercellular adhesion molecule 1.
- ^ a b Xin W, et al. Escin exerts synergistic anti-inflammatory effects with low doses of glucocorticoids in vivo and in vitro. Phytomedicine. (2011)
- ^ Zhang F, et al. Synergistic protective effects of escin and low‑dose glucocorticoids on blood‑retinal barrier breakdown in a rat model of retinal ischemia. Mol Med Rep. (2013)
- ^Â Deciphering New Molecular Mechanisms of Mast Cell Activation.
- ^ Bloemen K, et al. The allergic cascade: review of the most important molecules in the asthmatic lung. Immunol Lett. (2007)
- ^ Marshall JS. Mast-cell responses to pathogens. Nat Rev Immunol. (2004)
- ^ Inagaki N, Nagai H. Analysis of the mechanism for the development of allergic skin inflammation and the application for its treatment:mouse models for the development of remedies for human allergic dermatitis. J Pharmacol Sci. (2009)
- ^ Shum BO, Rolph MS, Sewell WA. Mechanisms in allergic airway inflammation - lessons from studies in the mouse. Expert Rev Mol Med. (2008)
- ^ Sipos W, et al. Escin inhibits type I allergic dermatitis in a novel porcine model. Int Arch Allergy Immunol. (2013)
- ^ Pirard J, et al. Double blind study of reparil in proctology. Rev Med Liege. (1976)
- ^ MacKay D. Hemorrhoids and varicose veins: a review of treatment options. Altern Med Rev. (2001)
- ^ Suter A, Bommer S, Rechner J. Treatment of patients with venous insufficiency with fresh plant horse chestnut seed extract: a review of 5 clinical studies. Adv Ther. (2006)
- ^ Heck AM, DeWitt BA, Lukes AL. Potential interactions between alternative therapies and warfarin. Am J Health Syst Pharm. (2000)
- ^ Fujii Y, et al. Benign renal tumors detected among healthy adults by abdominal ultrasonography. Eur Urol. (1995)
- ^ Eble JN. Angiomyolipoma of kidney. Semin Diagn Pathol. (1998)
- ^ Snow A, et al. Life-threatening rupture of a renal angiomyolipoma in a patient taking over-the-counter horse chestnut seed extract. J Emerg Med. (2012)
- ^ Escribano MM, et al. Contact urticaria due to aescin. Contact Dermatitis. (1997)
- ^ Muñoz X, et al. Occupational asthma related to aescin inhalation. Ann Allergy Asthma Immunol. (2006)