7 Keto DHEA

October 3, 2020

Overview

7-keto-DHEA is formed from dehydroepiandrosterone (DHEA) in the body. DHEA is a "parent hormone" produced by glands near the kidneys. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of steroid hormones in the blood.

People take 7-keto-DHEA to speed up metabolism and heat production, which can promote weight loss. 7-keto-DHEA is also used to improve lean body mass and build muscle, increase the activity of the thyroid gland, boost the immune system, enhance memory, and slow aging. It is also used to treat depression, anxiety, and post-traumatic stress disorder (PTSD).

Classification

Is a Form of:

Hormone

Primary Functions:

Speed up metabolism

Also Known As:

(3-beta)-3-hydroxyandrost-5-ene-7,17-dione; (3S,8R,9S,10R,13R,14S)-3-hydroxy-10

How Does It Work?

7-keto-DHEA might promote weight loss by speeding up the body’s metabolism and converting more energy to heat instead of storing it as fat.

Uses

Promoting weight loss. Early research shows that taking 7-keto-DHEA along with exercise might help obese adults lose weight and fat.
Improving lean body mass.
Building muscle.
Increasing activity of the thyroid gland.
Boosting the immune system.
Enhancing memory.
Reducing signs of aging.
Depression.
Anxiety.
Post-traumatic stress disorder (PTSD).
Other conditions.

Recommended Dosing

ADULTS
BY MOUTH:

For weight loss: 100 mg twice daily has been used.

7 Keto DHEA Supplements Frequently Asked Questions

Can 7 keto DHEA cause hairloss?

Fortunately there is another alternative to DHEA. Concerns about DHEA causing hair loss in men has led to the development of a metabolite of DHEA known as 7 Keto DHEA. It's believed that 7 Keto DHEA has most of the established benefits of DHEA without breaking down into estrogen and testosterone and causing hair loss.

Is 7 Keto DHEA the same as DHEA?

7-keto-DHEA is a by-product of dehydroepiandrosterone (DHEA), a chemical that is formed in the body. DHEA is a "parent hormone" produced by glands near the kidneys. But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen.

What is 7 keto DHEA 25mg?

7-KETO® DHEA 25 mg. 7-KETO DHEA is a non-hormonal metabolite of DHEA that can promote metabolic support without converting to testosterone or estrogen.

Which is better 7 keto or DHEA?

But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. 7-keto-DHEA is also used to improve lean body mass and build muscle, increase the activity of the thyroid gland, boost the immune system, enhance memory, and slow aging.

How long should I take 7 Keto DHEA?

7-Keto is likely safe and has a low risk of serious side effects. One study showed that the supplement was well-tolerated in men at doses up to 200 mg per day for four weeks ( 11 ). Most 7-keto-DHEA supplements on the market contain 100 mg per serving and commonly recommend taking two servings per day with food (12).

Can 7 keto DHEA cause weight gain?

But unlike DHEA, 7-keto-DHEA is not converted to steroid hormones such as androgen and estrogen. Taking 7-keto-DHEA by mouth or applying it to the skin does not increase the level of steroid hormones in the blood. People take 7-keto-DHEA to speed up metabolism and heat production, which can promote weight loss.

Does DHEA reduce weight?

DHEA and Weight Loss

A version of DHEA supplement known as 7-Keto has been widely promoted as an aid for reducing body fat and raising metabolism. The idea is that leaner body tissue and higher metabolism will burn calories more efficiently, making it easier to not only lose weight but also keep it off.

What are the benefits of 7 Keto DHEA?

Why is 7 keto DHEA banned?

Banned by WADA

7-keto-DHEA supplements have been suggested to trigger positive tests for performance-enhancing drugs ( 13 ). As such, the World Anti-Doping Association (WADA) has listed the supplement as a prohibited anabolic agent (14).

Does 7 keto DHEA increase estrogen?

Can you take 7 Keto at night?

People should avoid taking 7-Keto in the evening, as high blood levels at bedtime could stimulate brain activity and cause insomnia. Because 7-Keto is a natural hormone metabolite and is easily assimilated, it can be taken with a meal or on an empty stomach.

Do Keto pills work without the Diet?

Ketone supplements are claimed to put your body into ketosis without having to follow a ketogenic diet. One study found that exogenous ketone supplements may decrease appetite for over four hours when taken in a fasted state, but other research suggests that they may hinder weight loss efforts.

Can 7 keto side effects?

7-keto-DHEA is POSSIBLY SAFE when taken by mouth for up to 8 weeks. It might cause mild side effects such as nausea, dizziness, or low blood pressure in some people.

Why Does DHEA cause hair loss?

To the extent that DHEA produces extra testosterone (an iffy claim), then DHEA can also worsen hair loss in men that have the gene for androgenetic alopecia.

What time of day should you take DHEA?

Replacement consists of a single oral dose of 25–50 mg DHEA in the morning. However, not all investigators have found effects of DHEA on well-being, most likely because of small sample size and short duration of treatment.

Does DHEA reduce belly fat?

CONTEXT: Dehydroepiandrosterone (DHEA) administration has been shown to reduce accumulation of abdominal visceral fat and protect against insulin resistance in laboratory animals, but it is not known whether DHEA decreases abdominal obesity in humans.

How much DHEA can you take a day?

It's best to speak with a physician before beginning to take a DHEA supplement. Summary: A common daily dose is 25–50 mg. This dosage has been safely used for up to two years without severe side effects. However, you should speak with your physician prior to using this supplement.

Clinical Studies

^ a b The effect of 7-Keto Naturalean™ on weight loss: A randomized, double-blind, placebo-controlled trial.
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^ a b Kazihnitková H, et al. A novel radioimmunoassay of 7-oxo-DHEA and its physiological levels. Steroids. (2007)
^ a b c Davidson M, et al. Safety and pharmacokinetic study with escalating doses of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy male volunteers. Clin Invest Med. (2000)
^ Ergosteroids VII: perchloric acid-induced transformations of 7-oxygenated steroids and their bio-analytical applications—a liquid chromatographic-mass spectrometric study.
^ Marwah A, Marwah P, Lardy H. Development and validation of a high-performance liquid chromatography assay for the quantitative determination of 7-oxo-dehydroepiandrosterone-3beta-sulfate in human plasma. J Chromatogr B Biomed Sci Appl. (1999)
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^ Rijk JC, et al. Bovine liver slices: A multifunctional in vitro model to study the prohormone dehydroepiandrosterone (DHEA). Toxicol In Vitro. (2012)
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^ Fitzpatrick JL, et al. Metabolism of DHEA by cytochromes P450 in rat and human liver microsomal fractions. Arch Biochem Biophys. (2001)
^ a b c d e f Hennebert O, et al. Dehydroepiandrosterone 7alpha-hydroxylation in human tissues: possible interference with type 1 11beta-hydroxysteroid dehydrogenase-mediated processes. J Steroid Biochem Mol Biol. (2007)
^ Le Mée S, et al. 7beta-Hydroxy-epiandrosterone-mediated regulation of the prostaglandin synthesis pathway in human peripheral blood monocytes. Steroids. (2008)
^ Traish AM, et al. Dehydroepiandrosterone (DHEA)--a precursor steroid or an active hormone in human physiology. J Sex Med. (2011)
^ El Kihel L. Oxidative metabolism of dehydroepiandrosterone (DHEA) and biologically active oxygenated metabolites of DHEA and epiandrosterone (EpiA)--recent reports. Steroids. (2012)
^ Morfin R, Courchay G. Pregnenolone and dehydroepiandrosterone as precursors of native 7-hydroxylated metabolites which increase the immune response in mice. J Steroid Biochem Mol Biol. (1994)
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^ Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11β-hydroxysteroid dehydrogenases?.
^ Robinzon B, Prough RA. Interactions between dehydroepiandrosterone and glucocorticoid metabolism in pig kidney: nuclear and microsomal 11beta-hydroxysteroid dehydrogenases. Arch Biochem Biophys. (2005)
^ a b c Mitić T, et al. 11β-Hydroxysteroid Dehydrogenase type 1 contributes to the Balance Between 7-Keto- and 7-Hydroxy-Oxysterols in vivo. Biochem Pharmacol. (2013)
^ Nashev LG, et al. Hexose-6-phosphate dehydrogenase modulates 11beta-hydroxysteroid dehydrogenase type 1-dependent metabolism of 7-keto- and 7beta-hydroxy-neurosteroids. PLoS One. (2007)
^ a b c d e f g h i Sulcová J, et al. Delayed effects of short-term transdermal application of 7-oxo-dehydroepiandrosterone on its metabolites, some hormonal steroids and relevant proteohormones in healthy male volunteers. Clin Chem Lab Med. (2005)
^ a b Shi J, Schulze S, Lardy HA. The effect of 7-oxo-DHEA acetate on memory in young and old C57BL/6 mice. Steroids. (2000)
^ Memory-enhancing effects in male mice of pregnenolone and steroids metabolically derived from it.
^ Flood JF, Smith GE, Roberts E. Dehydroepiandrosterone and its sulfate enhance memory retention in mice. Brain Res. (1988)
^ Flood JF, Roberts E. Dehydroepiandrosterone sulfate improves memory in aging mice. Brain Res. (1988)
^ a b c d e f A randomized, double-blind, placebo-controlled study of 3-acetyl-7-oxo-dehydroepiandrosterone in healthy overweight adults.
^ Duskova M, et al. 7-hydroxylated derivatives of dehydroepiandrosterone as possibly related to menstrual mood change in healthy women. Endocr Regul. (2011)
^ a b c Amato RJ, Hulin MW, Winsauer PJ. A comparison of dehydroepiandrosterone and 7-keto dehydroepiandrosterone with other drugs that modulate ethanol intake in rats responding under a multiple schedule. Behav Pharmacol. (2012)
^ Melchior CL, Ritzmann RF. Dehydroepiandrosterone enhances the hypnotic and hypothermic effects of ethanol and pentobarbital. Pharmacol Biochem Behav. (1992)
^ a b Sageman S, Brown RP. 3-acetyl-7-oxo-dehydroepiandrosterone for healing treatment-resistant posttraumatic stress disorder in women: 5 case reports. J Clin Psychiatry. (2006)
^ Sedláčková B, et al. 7-oxygenated derivatives of dehydroepiandrosterone and obesity. Prague Med Rep. (2012)
^ Bobyleva V, et al. Concerning the mechanism of increased thermogenesis in rats treated with dehydroepiandrosterone. J Bioenerg Biomembr. (1993)
^ Lardy H, et al. Induction of thermogenic enzymes by DHEA and its metabolites. Ann N Y Acad Sci. (1995)
^ a b Bobyleva V, et al. The effects of the ergosteroid 7-oxo-dehydroepiandrosterone on mitochondrial membrane potential: possible relationship to thermogenesis. Arch Biochem Biophys. (1997)
^ a b Zenk JL, Frestedt JL, Kuskowski MA. HUM5007, a novel combination of thermogenic compounds, and 3-acetyl-7-oxo-dehydroepiandrosterone: each increases the resting metabolic rate of overweight adults. J Nutr Biochem. (2007)
^ Agarwal AK. Cortisol metabolism and visceral obesity: role of 11beta-hydroxysteroid dehydrogenase type I enzyme and reduced co-factor NADPH. Endocr Res. (2003)
^ Tomlinson JW, et al. 11beta-hydroxysteroid dehydrogenase type 1: a tissue-specific regulator of glucocorticoid response. Endocr Rev. (2004)
^ Muller C, et al. Inter-conversion of 7alpha- and 7beta-hydroxy-dehydroepiandrosterone by the human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. (2006)
^ Balázs Z, et al. Hexose-6-phosphate dehydrogenase modulates the effect of inhibitors and alternative substrates of 11beta-hydroxysteroid dehydrogenase 1. Mol Cell Endocrinol. (2009)
^ Hennebert O, et al. 7alpha- and 7beta-hydroxy-epiandrosterone as substrates and inhibitors for the human 11beta-hydroxysteroid dehydrogenase type 1. J Steroid Biochem Mol Biol. (2007)
^ Robinzon B, et al. Glucocorticoids inhibit interconversion of 7-hydroxy and 7-oxo metabolites of dehydroepiandrosterone: a role for 11beta-hydroxysteroid dehydrogenases. Arch Biochem Biophys. (2003)
^ Muller C, et al. Dehydroepiandrosterone and its 7-hydroxylated metabolites do not interfere with the transactivation and cellular trafficking of the glucocorticoid receptor. J Steroid Biochem Mol Biol. (2004)
^ Mo Q, Lu SF, Simon NG. Dehydroepiandrosterone and its metabolites: differential effects on androgen receptor trafficking and transcriptional activity. J Steroid Biochem Mol Biol. (2006)
^ a b Miller KK, et al. DHEA metabolites activate estrogen receptors alpha and beta. Steroids. (2013)
^ Granata OM, et al. Androgen metabolism and biotransformation in nontumoral and malignant human liver tissues and cells. J Steroid Biochem Mol Biol. (2009)
^ Hu Y, et al. Modulation of aromatase expression by BRCA1: a possible link to tissue-specific tumor suppression. Oncogene. (2005)
^ Hammond GL, Wu TS, Simard M. Evolving utility of sex hormone-binding globulin measurements in clinical medicine. Curr Opin Endocrinol Diabetes Obes. (2012)